Overview of Vitamin D Life

Although researchers, physicians, and clinical nutritionists can't agree completely on dose rates, recommended blood levels, and expected clinical outcomes, there is no question that vitamin D status plays an important role in reducing, preventing, and in some cases, treating a wide range of chronic degenerative medical conditions. The purpose of the Vitamin D Life is to provide a convenient, comprehensive, and authoritative resource to investigate how optimizing vitamin D status may be helpful for you or someone you care about. It's a big subject so we urge you to spend some time exploring and learning about this important nutrient.

Updated 2017

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Vitamin D is associated with many health problems

Less sun ==> Less Vitamin D ==> Less Health (chart)

click on image for details and translation
70 Proofs that Vitamin D prevents or treats the following diseases
ADHD,  Alcoholic Liver Cirrhosis,  ALS,  Alzheimer's,  Antibiotic Use in Seniors,  Asthma,  Autism,  Autoimmune Diseases,   Back pain,  Blood Cell Cancer,   Breast Cancer,   Cardiovascular,  Cholesterol,  Chronic Hives,  Chronic Kidney Disease,  Cluster Headaches,  Congestive Heart Failure (Infants),  COPD,  Crohn's Disease,  C-Section and Pregnancy Risks,  Cystic Fibrosis,  Depression,   Diabetes,  Diabetic Neuropathy,  Eczema,   Falls,  Fatigue,  Fatty Liver (Child),  Fibromyalgia,  Gestational Diabetes,  Gingivitis,  Growing Pains,  Hay Fever,  Heart Attack,  Hemodialysis,  Hepatitis-C,   Hip Fractures,  Hypertension,  Influenza,  Irritable Bowel Syndrome,  Ischemic Stroke,  Knee Osteoarthritis,  Leg Ulcers,   Low Birth Weight,  Lupus,  Male Infertility,   Menstrual Pain,  Metabolic Syndrome,  Middle Ear Infection (Infants),  Mite Allergy,  Multiple Sclerosis,  Non-Alcoholic Fatty Liver Disease,  Osteoarthritis,  Parkinson's Disease,  Perinatal Depression,  Pneumonia (Ventilator-associated),  Poor Sleep,  PreDiabetes,  Preeclampsia,  Pre-term Birth,  Prostate Cancer,  Quality of Life,   Raynaud's Pain,   Respiratory Tract Infection,  Restless Leg Syndrome,   Rheumatoid Arthritis,   Rickets,  Sarcopenia,  Sepsis,  Short Neonates,  Sickle Cell,  Stronger Senior Muscles,  Survive ICU,  TB,  Tonsillitis,  Trauma Death,  Traumatic Brain Injury,  Tuberculosis,  Ulcerative Colitis,  Urinary Tract Infection,  Vaginosis,  Vertigo,  Warts,  Weight Loss

Reminder: Translate icon in the upper right selects a different language
Click on underlined items for details

Health Problem	Treat Prevent	Reduction by Vit D	RCT = Randomized Controlled Trial    * = link to additional RCT CT = Clinical Trial
Hypertension	T P	149 to 142 mm Hg HT risk reduced 10X	RCT*  *, 2400 IU.  100,000 IU* When Vitamin D > 40 ng
Cardiovascular after attack	T	32 % fewer deaths	CT 1000 IU
Diabetes Type 1	P	85 %	12,000 kids, 2000 IU
Diabetes Type 2	T	62 %	RCT* CRP reduction, 4000 IU Injection is far better - RCT * RCT 50,000 IU/2weeks + probiotics RCT 5,000 IU daily 6 months
Back Pain	T	95 % reduced 50%	5000/10000 IU 60,000 IU weekly
Influenza	P	90 %	RCT *, 2000 IU
Falls	P	50%	RCT, 100,000 IU monthly RCT with Meals on Wheels 2016
Hip Fractures	P	30 %	RCT * 800 IU
Rickets	P	98 %	Turkey, 400 IU NOT RCT, given to all children
Raynaud's Syndrome	T	40 %	RCT, visual scale, 20000 IU Avg
Menstrual pain	P	76 %	RCT, 7000 IU Avg, 70% reduction 2018 PMS reduced by half
Pregnancy risks	P	50 %	RCT, 4000 IU
C-section, unplanned	P	50 %	RCT, 4000 IU, small study
Low birth weight	P	60 %	RCT * 1000 IU of D2
TB	P	60 %	RCT, 800 IU
Breast Cancer	P	60 %	RCT, 1100 IU (2007)
Rheumatoid Arthritis pain	T	40 %	RCT, 500 IU, added to prescription
Cystic Fibrosis	T	75 % 2nd study improved	RCT, pilot 4X fewer deaths 250,000 IU RCT, pilot 8,200 IU
Chronic Kidney	T	90 to 70 PTH	RCT, 3500 IU,
Respiratory Tract Infection	P	63 %	3 RCT, 4000 IU 1 year 2nd 2000/800 IU 20,000 IU weekly
Lupus	T T	zero flares Pain reduced	Loading then 100,000 IU monthly, RCT too RCT 4,000 IU
Sickle Cell	T	Less pain	RCT, up to 100,000 IU/week
Leg ulcer healing	T	4X faster	RCT, 50,0000 IU/week, small study
Traumatic Brain Injury	T	2X	RCT, 20,0000 IU/day with progesterone
Parkinson's Disease	T	Stabilized	RCT, 1200 IU/day
Multiple Sclerosis	P T	68% 95% were CURED	RCT, 7100 IU prevent pre-MS ==> MS 20,000 to 140,000 IU/day
Congestive Heart Failure	T	90 %	RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection	P	30 %	RCT, 1000 IU infants
Gingivitis	T	88 %	RCT, 2000 IU
Muscle in seniors	T	17 % more muscle	RCT, 4000 IU
Antibiotic use when >70y	T	47 %	RCT, 60,000 IU monthly
Infants taller	Benefit	1 cm tall	RCT, 50,000 IU weekly, for 8 weeks while pregnant
Gestational Diabetes	T	Reduced 3X	RCT, 2 doses of 50,000 IU
After Heart Attack	T	+6% ejection fraction	RCT, 800,000 IU one time
Prostate Cancer	T	Fewer +cores	RCT, 4000 IU (2012)
Asthma	P   T	Reduced symptoms	RCT, 60K IU/month; RCT 50K IU/week Need good D at 4 weeks into preg.
Depression	T	Reduced	RCT 300,000 IU injection RCT 1500 IU helped Prozac RCT 50,000 IU weekly, elderly
Low vitamin D while breastfed	P	All infants > 20 mg	RCT, 5,000 IU
Fibromyalgia	T	Half of many still has Fibro	RCT, 30-48 ng RCT 50K IU/week
Hives, Chronic	T	Reduced 40%	RCT, 4000 IU added
Cholesterol	T	Reduced 4 mg	RCT, 400 IU + Ca
Weight Loss	T	lost 5 more lbs	RCT, 2000 IU +diet +exercise
Gestational Diabetes	P	40%	RCT * , 5,000 IU
Chronic Obstructive Pulmonary Disease	T	17X improvement	CT, 50,000 IU weekly RCT 100,000 IU monthly
Asthma	T	1/2 Asthma attacks	RCT >42 mg of vitamin D
Quality of Life (QoL)	T	Nursing Home QoL	CT, 4,000 IU in daily bread
Death of Critically Ill Patients	T	20% increase in survivability	RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome	T	Score 26 ==> 10	CT, Vitamin D dose size not stated in abstract
Hepatitis-C	T	Aided normal drugs	RCT 2.000 IU
Crohn's disease	T	improved when > 30 ng 2nd study fewer relapses	RCT 2,000 IU 10,000 IU RCT
Pre-term birth	P	2.5X decrease, also: fewer c-section & better Apgar	RCT 2,000 IU India
Cluster headaches	T	CH eliminated in 60%	10,000 IU, Mg, Omega-3, etc
Autism	T	80% improved	CT 300 IU/kg/day for 3 months
PreDiabetes	T	~20% reduced	RCT 60,000 IU/month
Weight loss: Overweight and Obese	T	12 lbs in 6 months	RCT 100,000 IU/month
Sarcopenia = muscle loss	T	27% increase	RCT 1,000 IU
Growing Pains	T	60% decrease	~100,000 IU/month -NOT RCT 2nd study, similar results
Osteoarthritis pain	T	60% decrease	50,000 IU/weekly - NOT RCT
ALS	T	helped	2,000 IU - NOT RCT, given to all
Vertigo	T	3X reduction if raised > 10ng	600,000 IU load, then maint. NOT RCT, given to all
Warts	T	80% eliminated injection	NOT RCT 60,000 IU/injection
Metabolic Syndrome	P	reduced 44% when VitD increased by 30 ng	NOT RCT, given to all
Hay fever	P	reduced 48%	RCT   1,000 IU for 30 days
Preeclampsia	P	Recurrance cut in half 3 RCT 3.6 X less likely if > 30 ng	50,000 IU every 2 weeks 4,000 IU daily
Blood cell cancer Multiple Myeloma	T	Survival 90% vs 50%	10,000 IU/week NOT RCT, given to all
Irritable Bowel Syndrome	T	Reduced	3,000 IU spray RCT
Urinary Tract Infection	P	50% reduction	RCT 20,000 IU weekly
Mite Allergy	P	5X reduction	RCT 2,000 IU preg, 800 IU child
Perinatal depression (depression near birth)	T	50% reduction	RCT 2,000 IU for just a few weeks
Vaginosis	T	10X reduction	RCT 2,000 IU
Eczema	T	Reduced	2 RCT 1,600 IU
Non-Alcoholic Fatty Liver Disease	T	Reduced	RCT 20,000 IU weekly
Knee Osteoartiritis	T	Pain Reduced	RCT 60,000 IU monthly after loading dose
Tuberculosis	T	Faster Recovery	RCT single 450,000 IU dose
Stroke - Ischemic	T	Faster Recovery	RCT single 600,000 IU injection RCT single 300,000 IU injection
Sepsis	T	Reduce ICU and Hospital length of stay by 7 days each	RCT 400,000 IU
Trauma deaths	T	50% fewer deaths	Vitamin D & Glutamine NOT RCT, given to all
Hemodialysis patients	T	helped	50,000 IU weekly NOT RCT, given to all
Fatty liver - child	T	2 X reduction	RCT  Vitamin D & DHA
Fatigue	T	Reduced	100,000 IU single dose NOT RCT, given to all
Sleep Disorders	T	Nicely treated	RCT  50.000 IU bi-weekly
Pneumonia (Ventilator-associated)	T	RCT   Death rate cut in half	300,000 IU injection
Infertile males	T	birth rate doubled	RCT   300,000 IU + maint
Waist size	T	Waist size reduced 3 cm	100,000 IU loading + maint for 6 months for those with Metabolic Syndrome NOT RCT, given to all
Attention Deficient Hyperactivity Disorder	T	Reduced Reduced	RCT  3,000 IU for 12 weeks RCT  50,000 IU weekly
Alcoholic liver cirrhosis	T	improved survival	1,000 IU of vitamin D NOT RCT
Diabetic nephropathy	T	Reduced HOMA-IR, FRS	RCT 50,000 IU weekly
Ulcerative Colitis	T	Reduced 60%	RCT 50,000 IU nano daily for a week
Obese weight loss	T	Lost 3X more pounds	$10 of Vitamin D added to   calorie restriction & walking
Endometriosis	T	Nicely treated	RCT  50.000 IU bi-weekly
Diabetic Wounds	T	4X more likely to heal	RCT  6,400 daily
Alzheimer's	T	Often reverse	Each person gets a different amount of Vit D, Omega-3, B12, Iron, etc
Autoimmune	P	Decrease 30%	RCT  Vit D + Omega-3
Smoking	T	reduce problems	RCT  50,000 bi-weekly
Tonsillitis	T	Virtually eliminated	RCT  50,000 weekly

Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets it vitamin D

• 2 are meta-analyses of multiple RCTs
• Vitamin D was given to ALL infants in the entire country (Rickets) - not an RCT
• In several studies, researchers felt that it was unethical not to give vitamin D to everyone
• In some studies, the dose size varied with the needs of the person (overweight, etc)
• In some studies, the COFACTORS were adjusted to the needs of the patients
  • Curing requires the dose size and cofactors to be adjusted to the needs of each patient.

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Many Clinical Trials have not found a benefit because of one or more of the following failures:

1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
   The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
   Note: Infrequent dosing also causes unbalancing of the body's chemistry
4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
5. Fails to use D3 form, instead uses the less effective D2 form
6. Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
   Also, differences in Magnesium can result in 30% change in response to vitamin D
   Magnesium is dependent on water, food, supplements
7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

Many Meta-Analyses also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be a many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then there would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D

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See also Vitamin D Life: Random Controlled Trials with vitamin D  intervention

• Intervention - Vitamin D 799 Interventions
  • Note: It sorts the interventions by health problem as well as by date
• Vitamin D intervention trials - a long list - May 2014 1204 trials
  2176 Vitamin D clinical trials as of June 2020: Nutrition Disorders 621, Vitamin D Deficiency 619, Malnutrition 601, Avitaminosis 586, Deficiency Diseases 583, **Metabolic Diseases 489. Musculoskeletal Diseases 362, Bone Diseases 317. Bone Diseases, Metabolic 282, Endocrine System Diseases 241. Osteoporosis 209, Immune System Diseases 190, Kidney Diseases 168, Communicable Diseases 164. Infection 164
  • Update Jan 2024   2835 Clinical Trials with Vitamin D
• Systematic Reviews or Meta-Analysis of Vitamin D 641 items
• 137 health problems associated with low vitamin D – meta-meta-analysis April 2014
• Intervention - 2-30 days 261 items

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + K combined

Vitamin D = 2199, Others = 1803 Vitamin A 702 + Vitamin C 768 + Vitamin K 333    as of Aug 2020

See also Vitamin D Life

• Overview: Vitamin D also TREATS
• Is it ethical to not give vitamin D in osteoporosis trials– NEJM Sept 2010
  • Some Vitamin D RCT are not being created because the researchers do not want to deprive the benefits to half of the patients
  • Some Vitamin D RCT cannot be started because too many candidates are already taking vitamin D
• Reasons for Vitamin D deficiency
• List of all categories of Vitamin D Information and number of items in each
• List of all Overviews of Vitamin D 74 items along with related searches

CLICK ON chart for more information and translation

Vitamin D is especially needed during pregnancy

Problem	Vit. D Reduces	Evidence
0. Chance of not conceiving	3.4 times	Observe
1. Miscarriage	2.5 times	Observe
2. Pre-eclampsia	3.6 times	RCT
3. Gestational Diabetes	3 times	RCT
4. Good 2nd trimester sleep quality	3.5 times	Observe
5. Premature birth	2 times	RCT
6. C-section - unplanned	1.6 times	Observe
Stillbirth - OMEGA-3	4 times	RCT - Omega-3
7. Depression AFTER pregnancy	1.4 times	RCT
8. Small for Gestational Age	1.6 times	meta-analysis
9. Infant height, weight, head size      within normal limits		RCT
10. Childhood Wheezing	1.3 times	RCT
11. Additional child is Autistic	4 times	Intervention
12.Young adult Multiple Sclerosis	1.9 times	Observe
13. Preeclampsia in young adult	3.5 times	RCT
14. Good motor skills @ age 3	1.4 times	Observe
15. Childhood Mite allergy	5 times	RCT
16. Childhood Respiratory Tract visits	2.5 times	RCT

RCT = Randomized Controlled Trial

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Also, The Vitamin D Receptor limits the amount of Vitamin D in the blood actually gets to the tissue

The risk of 48+ diseases at least double with poor Vitamin D Receptor

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Short URL = is.gd/dproof

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6 times to 55 times more likely to get these health problems

• Many health problems associated with low vitamin D
       click to read the studies
• 55 X more likely to have bone fracture requiring surgery
• 30 X more likely for COPD becoming suddenly worse
• 25 X more likely to have senior moment
• 23 X more likely to have vertigo
• 19 X more likely to get dementia
• 17 X more likely to have muscle inflammation
• 14 X more likely to die after first cardiovascular event
• 14 X more likely for dark-skinned children to get T1 diabetes
• 12 X more likely to die from elderly pneumonia
• 11 X more likely to be allergic to peanuts
• 10 X more reactions to flu vaccine
• 10 X more likely for stroke patients to become depressed
• 9 X more likely to have Gastric Cancer
• 8 X more likely to have Autoimmune Hepatitis
• 8 X more likely for alcoholic to have Alcoholic liver disease
• 8 X more likely to get lupus
• 7 X more likely to have low birth weight infant
• 7 X more likely for pregnant teen to have anemia
• 7 X more likely to have leg pain
• 7 X increased chance of death from coronary artery disease
• 6.5 X more likely for infant to be Small for Gestational Age
• 6 X worse outcome following Sudden cardiac arrest
• 6 X more likely to get hip fracture after stroke
• 6 X more likely to die after coronary bypass
• 6 X more likely to have allergic rhinitis
• 6 X more likely to get diabetes if abdominal obese
• 6 X more likely to get cancer in children

CLICK HERE for entire 3X to 55X list for more information

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Health problem - examples

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Alzheimers-Cognition

Overview Alzheimer's-Cognition and Vitamin D has the following summary

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
• OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
  • It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  There are 13+ Alzheimer’s meta-analyses in Vitamin D Life
  There are 97+ Alzheimer’s studies in Vitamin D Life
  Dementia is associated with low vitamin D - many studies 50+ studies
  16+ studies in both categories Cognitive and Omega-3

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Breast Cancer

Overview Breast Cancer and Vitamin D contains the following summary and sections

• 24 Meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 252 items along with related searches
• Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
• Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
• Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
• Vitamin D both prevents and treats Breast Cancer – 2019

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Breathing

Breathing category starts with the following

445 items in Breathing category

Breathing-related Overviews at Vitamin D Life:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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Cardiovascular

Cardiovascular category listing has 507 items along with related searches507 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

• Overview Cardiovascular and vitamin D
• Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
• Coronary Artery Disease and Vitamin D - many studies 18+
• Cardiovascular problems reduced by Omega-3 - many studies 34+
• Arteries and Atherosclerosis and Vitamin D - many studies 71+
• Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
• Statins and Vitamin D - many studies 25+
• Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
• Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
• Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
• Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
• Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
• Heart attack ICU costs cut in half by Vitamin D – Oct 2018
• Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022

Cholesterol, Statins

• Cholesterol is needed to produce both Vitamin D and Cortisol
• Overview Cholesterol and vitamin D
• Statins and Vitamin D - many studies statins often reduce levels of vitamin D
• Statin side-effects are reduced by Vitamin D – US patent Application – April 2019

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Diabetes

Overview Diabetes and vitamin D appears to be due to a lack of Vitamin D

• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
      Elderly also spend less time outdoors and have more clothes on
• All items in category Diabetes and Vitamin D 537 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• 90% less T2 Diabetes in the group having lots of Vitamin D
• Appears that Magnesium helps both Prevention and Treatment
• Many diabetics would be better treated if Gut-Friendly Vitamin D were used

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

• Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

• Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
• Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
• Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
• Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
• T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
• Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021

50 ng of Vitamin D fights Diabetes

• Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
• Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018

T1 Diabetes

• T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
• Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
• Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019

Pre-Diabetes

• 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
• Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
• Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020

Diabetes, Metabolic Syndrome and Magnesium - many studies

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Falls and Fractures

Falls and Fractures category contains the following summary

• 254 items in FALLS and FRACTURES
• Vitamin D and Calcium cost-effectively reduce falls and fractures – April 2019
• see also Overview Seniors and Vitamin D
  • Overview Fractures and Falls and Vitamin D
  • Overview Fractures and vitamin D
  • Overview Muscles and Vitamin D

Falls

• Fall prevention - Vitamin D is one of the ways - umbrella review Jan 2024
• Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
• Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
• Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
• Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018
  • Note: It took 6 months to get to that level. Most trials last only 3 months
• Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
• Falls reduced by Vitamin D: 13 percent reduction if more than 700 IU – review of 38 trials – Aug 2022

Fracture

• Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023
• Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
• Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
• Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis – May 2019
• 75+ Hip fracture items in Vitamin D Life title   Click here for details

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Kidney

Overview Kidney and vitamin D contains the following summary

• FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
• FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
• FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
• FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
• FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
• FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
• FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
• Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
    Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
  Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
  Calcitriol - which bypasses the need for the kidney to activate vitamin D
    Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
      Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
• Category Kidney and Vitamin D contains 225 items

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Obesity

Overview Obesity and Vitamin D contains the following summary

• FACT: People who are obese have less vitamin D in their blood
• FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
• FACT: When obese people lose weight the vitamin D level in their blood increases
• FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
• FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
• FACT: Less weight gain by senior women with > 30 ng of vitamin D
• FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
• FACT: Obese lost 3X more weight by adding $10 of Vitamin D
• FACT: Those with darker skins were more likely to be obese Sept 2014
• OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
• OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
  • and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
• SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
• SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
    risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
• Obesity category has 428 items See also: Weight loss and Vitamin D - many studies   Child Obesity and Vitamin D - many studies

Obese need more Vitamin D

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

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Osteoporosis

Overview Osteoporosis and vitamin D contains the following summary

• FACT: Bones need Calcium (this has been known for a very long time)
• FACT: Vitamin D improves Calcium bioavailability (3X ?)
• FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
• FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
• FACT: Vitamin D supplements are very low cost
• FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
• FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
• FACT: Co-factors help build bones.
• FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
• It appears that to TREAT Osteoporosis:
•        Calcium OR vitamin D is ok
•        Calcium + vitamin D is good
•        Calcium + vitamin D + other co-factors is great
•        Low-cost Vitamin D Receptor activators sometimes may be helpful
• CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
• Category Osteoporosis has 215 items
• Category Bone Health has 307 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
Osteoporosis category includes the following

• 215 items in category - see also Overview Osteoporosis and vitamin D
• Overview Fractures and vitamin D
• Bone - Health 307 items
• Vitamin D Life pages with BONE MINERAL DENSITY or BMD in title 29+ pages
• Search Vitamin D Life for OSTEOPENIA 1740 items as of July 2020
• 13 articles are in both Osteroporosis and Vitamin D Receptor categories
• 9 articles are in both Osteroporosis and Meta-analysis categories
• 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013

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Pain

Pain - chronic category has the following

159 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 79 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 185 items as of Jan 2017
• Category Back Pain 42 items
• 7 pain studies in Vitamin D Life with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021

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Parkinson’s

Overview Parkinson's and Vitamin D contains the following summary

• Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
• Parkinson's category has 112 studies
• Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
• Parkinson patients: 60 % taking Vitamin D – Dec 2019
• Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
• Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
• 10 clinical trials for PD with vitamin D intervention as of June 2023
• Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
• Associated with PD are: Meta-analyses (12 ), Cognition (22 studies), Multiple Sclerosis (17 studies), VIRUS (4 studies), Omega-3 (3 studies), Vitamin D Receptor (11 studies)
• Note by the Founder of Vitamin D Life: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk

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Schizophrenia

Overview Schizophrenia and Vitamin D contains the following summary
14 reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored

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Sports

Overview Sports and vitamin D has the following summary
Athletes are helped by vitamin D by:

1. Faster reaction time
2. Far fewer colds/flus during the winter
3. Less sore/tired after a workout
4. Fewer micro-cracks and broken bones
5. Bones which do break heal much more quickly
6. Increased VO2 and exercise endurance Feb 2011
7. Indoor athletes especially need vitamin D
8. Professional indoor athletes are starting to take vitamin D and/or use UV beds
9. Olympic athletes have used UV/vitamin D since the 1930's
10. The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
11. Reduced muscle fatigue with 10,000 IU vitamin D daily
12. Muscle strength improved when vitamin D added: 3 Meta-analysis
13. Reduced Concussions
    See also: Sports and Vitamin D category 273 items

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Groups typically needing more Vitamin D

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Seniors need more vitamin D - 10 reasons

1. Senior skin produces 4X less Vitamin D for the same sun intensity
2. Seniors have fewer vitamin D receptor genes as they age
   Receptors are needed to get Vitamin D in blood actually into the cells
3. Many other Vitamin D genes decrease with age
4. Since many gene activations are not detected by a blood test,
   more Vitamin D is often needed, especially by seniors
5. Seniors are indoors more than when they were younger
   not as agile, weaker muscles; frail, no longer enjoy hot temperatures
6. Seniors wear more clothing outdoors than when younger
   Seniors also are told to fear skin cancer & wrinkles
7. Seniors often take various drugs which end up reducing vitamin D
   Some reductions are not detected by a vitamin D test of the blood
   statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
8. Seniors often have one or more diseases that consume vitamin D
   osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
12. Vitamin D is not as bioavailable in senior intestines
13. Seniors with poorly functioning kidneys do not process vitamin D as well
       Seniors category has 427 items

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 Infants-Child

Infant-Child category starts with

• No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
• 400 IU Vitamin D is no longer enough
  Was OK in the past century, but D levels have been dropping for a great many reasons.
  FDA doubles the amount of vitamin D permitted in milk – July 2016
• No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
• Review of 400 IU to 2000 IU daily and higher if non-daily
• Fewer pre-infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
• 1600 IU was the conclusion of three JAMA studies
     1000 IU recommended in France and Finland – 2013 - appears to be a good level
• 5X less mite allergy after add vitamin D
• Child bone fractures with low vitamin D were 55X more likely to need surgery
• 75 % of SIDS had low vitamin D
• Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
• 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
• Infants have gotten free 400 IU of vitamin D in Turkey since 2005, More for longer would be even better – Feb 2022
• Preemies should have vitamin D supplements – reaching an agreement – April 2021
• Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021

Having a good level of vitamin D cuts in half the amount of:

• Asthma, Chronic illness, Doctor visits, Allergies, infection
  Respiratory Tract Infection, Growing pains, Bed wetting

Need even more IUs of vitamin D to get a good level if;

• Have little vitamin D: premie, twin, mother did not get much sun access
• Get little vitamin D: dark skin, little access to sun
• Vitamin D is consumed faster than normal due to sickness
• Older (need at least 100 IU/kilogram, far more if obese)
• Not get any vitamin D from formula (breast fed) or (fortified) milk
  Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

• Sun is great – well known for 1,000’s of years.
  US govt (1934) even said infants should be out in the sun
• One country recommended 2,000 IU daily for decades – with no known problems
• As with adults, infants and children can have loading doses and rarely need tests
• Daily dose appears to be best, but monthly seems OK
• Vitamin D is typically given to infants in the form of drops
     big difference in taste between brands
     can also use water-soluable form of vitamin D in milk, food, juice,
• Infants have evolved to get a big boost of vitamin D immediately after birth
  Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
• 100 IU per kg of infant July 2011, Poland etc.
  
  More than 100 IU/kg is probably better
• 823 items in the category Infant/Child See also
• 34 pages in Vitamin D Life had BREASTFE*in title as of Jan 2022
• "BIRTH DEFECTS" 172 items as of July 2016
• Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1940 items as of Oct 2018
• 96 Vitamin D Life pages contained PRETERM or PREEMIE in title as of Aug 2021
• "SUDDEN INFANT DEATH" OR SIDS 214 items as of Dec 2020
• Overview of Rickets and Vitamin D
• Youth category listing has 174 items along with related searches
• Down syndrome and low vitamin D - several studies
• Rett syndrome associated with low vitamin D, treated by Omega-3

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Pregnant

Overview Pregnancy and vitamin D
Pregnancy category starts with

886 items in Pregnancy category

 - see also

• Overview Pregnancy and vitamin D
• Number of articles in both categories of Pregnancy and:Dark Skin 28;   Depression 21;   Diabetes 44;   Obesity 15;  Hypertension 44;   Breathing 35;  Omega-3 40;  Vitamin D Receptor 24 Click here for details
• All items in category Infant/Child 823 items
• Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
• 38+ papers with Breastfed etc, in the title
• Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
• 53+ preeclampsia studies
• 94+ studies with PRETERM in the title
• Fertility problem (PCOS) reduced by vitamin D: many studies 15+
• 94+ Gestational Diabetes
• Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
• Post-partum depression and low Vitamin D - many studies 15+ studies
• Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
• Search Vitamin D Life for "Assisted reproduction" 33 items as of Aug 2022
• Fertility and Sperm category listing has 134 items along with related searches
• (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
• Less labor pain if higher level of vitamin D – August 2021
• Healthy pregnancies need lots of vitamin D
• Ensure a healthy pregnancy and baby - take Vitamin D before conception
  

Problem	Vit. D Reduces	Evidence
0. Chance of not conceiving	3.4 times	Observe
1. Miscarriage	2.5 times	Observe
2. Pre-eclampsia	3.6 times	RCT
3. Gestational Diabetes	3 times	RCT
4. Good 2nd trimester sleep quality	3.5 times	Observe
5. Premature birth	2 times	RCT
6. C-section - unplanned	1.6 times	Observe
Stillbirth - OMEGA-3	4 times	RCT - Omega-3
7. Depression AFTER pregnancy	1.4 times	RCT
8. Small for Gestational Age	1.6 times	meta-analysis
9. Infant height, weight, head size      within normal limits		RCT
10. Childhood Wheezing	1.3 times	RCT
11. Additional child is Autistic	4 times	Intervention
12.Young adult Multiple Sclerosis	1.9 times	Observe
13. Preeclampsia in young adult	3.5 times	RCT
14. Good motor skills @ age 3	1.4 times	Observe
15. Childhood Mite allergy	5 times	RCT
16. Childhood Respiratory Tract visits	2.5 times	RCT

RCT = Randomized Controlled Trial
CLICK HERE to see entire page

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Darker Skin

• Overview Dark Skin and Vitamin D
• Dark skin pregnancies and Vitamin D - many studies
• Vitamin D deficiency diseases in dark skinned people living far from equator – Meta-analysis Oct 2013
• Forearm fracture 3.5X more often in black children with low levels of vitamin D – Sept 2012
• Extra 4,000 IU daily raised the vitamin D levels of blacks to that of whites – July 2012
• Increased risk of multiple sclerosis risk in African Americans due to genes – June 2013
• Differences in black and non-black mortality and vitamin D – Oct 2012
• Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015

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Other High Risk Groups

High Risk of little Vitamin D category listing has 64 items and has:

• 40 percent lower vitamin D level if work other shifts (Italy) – June 2015
• Burka clothing reduces vitamin D levels, which causes pregnancy problems – Oct 2015
• The only supplement NASA gives crews is vitamin D - Sept 2015
• People with health problems lacking noon sun (severe Multiple Sclerosis, etc.) have even lower levels of vitamin D – March 2015
• Intellectually disabled 2X more likely to have low vitamin D (shut-in) – Sept 2014
• 4.7X less likely to feed self in nursing home if vitamin D deficient – Oct 2013

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Vitamin D supplementation

Amount of vitamin D needed vs:

More vitamin D needed -nutshell category has the following

Age	Latitude	Season
Obesity	Skin color	Avoid Sun

Supplementation from Zika book (July 20, 2016)

Vitamin D Recommendations: based on hundreds of successful Vitamin D studies (with/without pregnancy)

• 4,000 IU daily average minimum amount of Vitamin D
  Similar dosing is 50,000 IU bi-weekly (Daily is probably slightly better)
  It is 1/3 the cost and easier to remember than daily dosing.
  Note: Taking vitamin D also increases chance of pregnancy
• More is needed if likely to have very low levels of vitamin D:
  6,000 IU daily average if:
  • having twins or had a recent birth,
  • health problems associated with low vitamin D
  • indoors a lot or avoid the sun
  • dark skin
  
  10,000 IU (50,000 IU every 5th day) if:
  • Obese

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 obesity study

• if diseases run in the family
• May want to restore levels as quickly as possible with 350,000 IU loading dose
  during pregnancy, especially if there is the threat of Zika
  this gets a strong immune system quickly, not with months of delay using a daily maintenance dose
  • 50,000 IU daily for 1 week if not pregnant
  • 50,000 IU every second day for 2 weeks if pregnant
• Start ASAP during pregnancy (even before) so as to both avoid Zika and have healthy pregnancy and infant
• Should use a vitamin D which has no known adverse affects
  No additives, no oils (30% of oil-based Vit D which restrict vitamin D adsorption)
• Most people (80%?) can take regular vitamin D capsules
  Options if:
  • Not want to take pills – use liquid Vitamin D or pour vitamin D powder from capsule into food/drink
  • Poor gut – several “gut friend” forms are available
  • Vegan – several forms of Vitamin D3 are made from plants such as lichen
  • Halal, Kosher, etc.
• Magnesium Cofactor 100+ miligrams of element daily – tell why especially during pregnancy
  • Increases the benefits of vitamin D
  • Decreases chance of allergic-type reaction to Vitamin D (from ~ 3 in 1000 to 1 in 1000)
• Omega-3 Cofactor
• Vitamin K2 cofactor
• Test for Vitamin D is nice but very expensive ($60) and not really essential
• Take vitamin D just after evening meal
  • about~30% more benefit with evening meal, but most anytime is OK
• Just concerned about average vitamin D during a 2 week time period
  4,000 IU taken daily is virtually identical to 50,000 IU once every two weeks
  OK to have missed your dose for a few days - just take nissed once all at once.

How often should I take 50,000 IU

How often should I take 50000 IU (1.25 mg) of vitamin D

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10 minutes of sun not enough

No – 10 minutes per day of sun-UVB is NOT enough

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Loading Dose - to get the benefit as soon as possible

Overview Loading of vitamin D contains the following

Loading dose: 200 studies at Vitamin D Life

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

• Loading = restore = quick replacement by 1 or more doses
• Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
  • = 2.5 to 25 milligrams
• The size of the loading dose is a function of body weight - see below
  • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
• Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
  • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
• Loading is typically oral, but can be Injection (I.M,) and Topical
• Loading dose is ~3X faster if done topically or swished inside of the mouth
  • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
• The loading dose persists in the body for 1 - 3 months
  • The loading dose should be followed up with on-going maintenance dosing
  • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
• About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
  • it appears prudent to test with a small amount of vitamin D before giving a loading dose
  • The causes of a mild allergic reaction appear to be: (in order of occurrence)
  • 1) lack of magnesium - which can be easily added
  • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
  • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
  • 4) allergy of the gut to Vitamin D - alternative = topical

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Toxicity is rare

Overview Toxicity of vitamin D

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Free Vitamin D evaluation service

Free Vitamin D evaluation service had the following questions
Positive answers indicates a possible vitamin D deficiency

• At night, I ...... have a cold feeling ... have legs that hurt ... have a restless sleep ... wake up suddenly
• During the day, I am...... listless ... tired ... lethargic ... uninspired
• I feel cramps or twitches...... in the leg ... in the arm ... in the hand ... in the eyelid
• I get dizzy...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• I feel sick...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• My head hurts or I feel pressure in my head...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
• If I stand or work for an extended period of time, it hurts...... in my neck ... in my lower back ... in the groin ... in the feet
• The Sun at noon causes...... circulatory problems ... headaches ... an itching skin ... red spots
• I repeatedly have...... cold hands ... cold feet ... cold legs ... white fingertips
• My fingernails have…   number of white spots

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Cofactors are important if you take a lot of vitamin D for a long time

Vitamin D Cofactors in a nutshell
!!!!Cofactors need to be adjusted when taking a lot of vitamin D for more than a month
"A lot" is more than 4,000 IU Vitamin D daily (average)
There is virtually no agreement as how much of each cofactor is needed vs vitamin D level
The first three cofactors have, like vitamin D, greatly decreased in the human diet in the past 50 years
The goal is to restore Vitamin D, Magnesium, Omega-3, and Vitamin K back to where they had been
   in a nutshell = summed up = condensed

Supplements categories in Vitamin D Life include

Supplement	# of studies		Increase D to tissue	How Often
Magnesium	349	Many people need Mg Vit D consumes Mg Muscle pain, Afib	30%	Several times a day
Vitamin K	152	Hard bones, soft arteries	115%	2 day
Omega-3	394	Synergistic with Vit D Independent of Vit D	30? %	2 day
Calcium	220	Reduce or add Vit K		2 day
Zinc	88	immunity	20 ?% if poor VDR	7 day
Boron	37	plants and animals need B	+20%	7 day
Resveratrol	47	antioxidant	>100% if poor VDR	Daily

Also    Vitamin C 54

Iodine 30

Iron 68

Vitamin B12 57

Selenium 25

Folate 31

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Magnesium

• About 1 in 300 people have a poor reaction to increasing Vitamin D
     but the Vitamin D reaction (muscle pain) is almost always due to lack of Magnesium
• Magnesium increases the benefits of vitamin D by about 30% (Mg and Vit. D are synergistic)
• Magnesium provides a great many health benefits independent of Vitamin D
• Magnesium is used in 8 stages of Vitamin D metabolism
• 100 milligrams of Magnesium supplement (say from Magnesium Chloride) may be enough, even with high levels of Vitamin D
  Some people (not a consensus) believe that only 100 mg of Mg can be taken up by the gut at a time
  Some people get 300+ mg of Magnesium daily from greens
  If possible, take your Magnesium several times during the day - not just once
  • Vitamin D appears to consume Magnesium
  • People with > 100 ng of Vitamin D (and do not consume Mg) are 2.5X more likely to have A-fib
  • Constipation due to low Magnesium after greatly increasing Vitamin D level (personal experience of the founder of Vitamin D Life)
• Overview Magnesium     Magnesium category has 349 items

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Omega-3

• Omega-3 increases active vitamin D - especially in people with poorly functioning livers or kidneys
• Need >1 gram of Omega-3. Note: different brands have widely different bio-availability
• Need to take with a fatty meal unless you use an emulsified form
• Overview Omega-3     Omega-3 category has 394 items

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Vitamin K2

• K2 Keeps Calcium in bones and out of arteries
• Calcification due to K2 deficiency may be a reason for increased mortality for some diseases for high vitamin D
• Probably need 100 micrograms per 2,000 IU of vitamin D (i.e. 500 micrograms for 10,000 IU of Vit D)
  • Perhaps Vitamin D consumes Vitamin K, so need more of it
• Vitamin D decreases the uptake of Vitamin K1 by 50%
  • Perhaps should not take K2 concurrently with Vitamin D.
• Overview Vitamin K2     Vitamin K category has 152 items

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Calcium

• Too much Calcium is associated with cardiovascular problems years later, not stronger bones
• Should have less than 750 milligrams of Calcium supplementation
• Drinking a lot of water helps flush any excess Calcium from the Kidneys
• VegiCalcium appears to be better than rock Calcium, and only costs 10 cents a capsule
• Overview Calcium     Calcium category has 220 items

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Boron - good, but not as essential

• Boron increases Vitamin D and Magnesium in the body by ~ 20%
• Most people Boron deficient now that commercial fertilizers are used
• Should have an average of 3 -10 milligrams of Boron daily
• Founder of Vitamin D Life takes a 30mg Boron capsule once every 4 days
• Boron category has 37 items

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Zinc - good, but not as essential

• Extra Zinc does not appear to increase D in the blood. but may increase D in the tissue
• Zinc is, however, essential to make Vitamin D Receptors and utilize Omega-3
• Low zinc is associated with many autoimmune diseases,infections, colds, etc
• Zinc, like Boron, is extremely low-cost and safe
• Zinc category has 88 items

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Unfortunately, cofactors as pills are costly and typically need to be taken daily

• The cost of cofactors is 10X to 100X more than vitamin D when taken as pills
• Many of the cofactors need be taken daily (vs Vitamin D can be taken weekly or bi-weekly)

Perspective of the importance of Vit D and co-factors to health

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See also Vitamin D Life

• Need to adjust cofactors if take 50,000 IU of vitamin D weekly – Nov 2013
• How you might double your response to vitamin D
  • primarily by increasing Magnesium, Boron, Vitamin K, Omega-3
• 20 reasons for not taking Vitamin D debunked
• Too much Vitamin D long-term problems if take too much vitamin D without balancing cofactors
• Low cost cofactors for vitamin D - includes a listing of what the founder of Vitamin D Life actually takes
• Supplements category listing has 104 items
  • Includes morality problems with >400 IU of Vitamin E
• Immune system is better fortified by nano forms of Vitamin D, Vit C, Vit B12, Omega-3, resveratrol, etc - March 2021
  • many of the vitamin D cofactors are available in nanoforms
• Dr. Ames triage theory - Vit D, Mg, etc. immediate needs reduce their use for long-term needs such as DNA repair
• Vitamin D Receptor is one of the genes which can block vitamin D from getting to the cells
  • The standard Vitamin D test cannot detect a poor Vitamin D Receptor
  • Adding more Vit D, Mg, Omega-3, Boron, Resveratrol, Zinc, etc. increases Vit D getting into the cells

See also - Excellent reviews of supplements at ConsumerLab

short URL = is.gd/Dplus

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Genes can restrict Vitamin D from getting to the cells

Even if vitamin D levels are OD (e.g. > 40 nanogram)
Genetics category listing contains the following

332 articles in the Genetics category

see also

• Vitamin D Receptor has 512 items
• Vitamin D Binding Protein = GC has 176 items
• CYP27B1 has 60 items
• CYP24A1 in title of 34+ items
• CYP2R1 25+ items
• Calcidiol has 46 items
• Calcitriol has 56 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your body
• 

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family

    especially if it is one of 51+ diseases related to Vitamin D Receptor

+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)+3) DNA and VDR tests - 120 to 200 dollars $100 to $250+4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)

   Genes are good, have enough Magnesium, etc.

+4) Back Pain

   probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc

• The founder of Vitamin D Life took action with clues #3&4

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Additional Vitamin D information

   from Increased visibility for Vitamin D Life pages

Vitamin D Life page	Comment
Vitamin D Life: Your Go-To Vitamin D Website - 2019
Does Less Sun mean More Disease	5 minute video summary
Some people have problems with vitamin D	Typically low Magnesium
One pill every two weeks gives you all the vitamin D most adults need	50,000 IU every 2 weeks
Vitamin D bulb for use in the home - or perhaps office
Vitamin D from low-cost UVB lamps
Hearing Loss appears to be prevented and treated with vitamin D
Vitamin D reduces hair loss - many studies
Headache with vitamin D may mean you need Magnesium
60,000 IU vitamin D weekly with daily Calcium was safe but not enough in the winter – 2012
Vitamins To Speed Up Metabolism And Aid Weight Loss – May 2011
Low cost vitamin D Blood Tests
Gallbladder removal and vitamin D deficiency	If Gallbladder has been removed must take some other form of Vit D Water soluable, etc.
Many reasons why vitamin D deficiency has become epidemic	35 reasons, 20 are new during the past 40 years
Intervention - Vitamin D	270 Vitamin D intervention studies
Diseases that may be related via low vitamin D
Reasons for low response to vitamin D
Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015	Example of huge Return On Investements
Vitamin D sprayed inside cheeks (buccal spray) - several studies
Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D)	"It is difficult to get a man to understand something when his salary is dependent upon his not understanding it"

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Shorturl = http://is.gd/VitDisgd (Vitamin D Is Good)