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Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018

Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer’s Disease

Mol Neurobiol. 2018; 55(8): 6463–6479. doi: 10.1007/s12035-017-0839-1
François Féron francois.feron at univ-amu.fr, Pascal Millet pascal.millet at univ-amu.fr.
Maria Morello morello at uniroma2.it; Véréna Landel, landel.verena at gmail.com; Emmanuelle Lacassagne, emmanuelle.lacassagne at gmail.com; Kevin Baranger. kevin.baranger at univ-amu.fr, Cedric Annweiler, Cedric.Annweiler at chu-angers.fr

Vitamin D Life

Mice were fed Zero, Normal, and High Vitamin D (HVD = 7,500 IU per kilogram of food)
   Note: Humans eat < 2 kilograms of food per day ==> ~13,000 IU
   Note: Very high dose vitamin D used to cure Multiple Sclerosis uses 20,000 - 140,000 IU daily
   Note: Across many diseases prevention needs only 1/3 to 1/5 of vitamin D needed to treat
     Note: 13,000 IU = 1/4 of 50,000 IU

Improved working memory of all mice if high dose vitamin D given early

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Prevented plaque from transgenic mice with high dose vitamin D at 1-6 months 

More brain cells with early high dose
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Removed plaque from transgenic mice with high dose vitamin D at 4-9 months

Plaque decreased with high dose later in life
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Life Extension Magazine winter edition covered this study

"Vitamin D Removes Amyloid Brain Plaque"
LEF Magazine continues to recommend 50-80 ng level of vitamin D via 5,000 to 8,000 IU


Additional mouse and Vitamin D studies in Vitamin D Life include


Alzheimers-Cognition - Overview starts with


Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

290 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search Vitamin D Life for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search Vitamin D Life for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014
https://vitad.org/tiki-index.php?page_id=8392

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See also web

 Download the PDF from Vitamin D Life

The impairment of hippocampal neurogenesis at the early stages of Alzheimer’s disease (AD) is believed to support early cognitive decline. Converging studies sustain the idea that vitamin D might be linked to the pathophysiology of AD and to hippocampal neurogenesis. Nothing being known about the effects of vitamin D on hippocampal neurogenesis in AD, we assessed them in a mouse model of AD. In a previous study, we observed that dietary vitamin D supplementation in female AD-like mice reduced cognitive decline only when delivered during the symptomatic phase. With these data in hand, we wondered whether the consequences of vitamin D administration on hippocampal neurogenesis are stage-dependent. Male wild-type and transgenic AD-like mice (5XFAD model) were fed with a diet containing either no vitamin D (0VD) or a normal dose of vitamin D (NVD) or a high dose of vitamin D (HVD), from month 1 to month 6 (preventive arm) or from month 4 to month 9 (curative arm). Working memory was assessed using the Y-maze, while amyloid burden, astrocytosis, and neurogenesis were quantified using immunohistochemistry. In parallel, the effects of vitamin D on proliferation and differentiation were assayed on primary cultures of murine neural progenitor cells. Improved working memory and neurogenesis were observed when high vitamin D supplementation was administered during the early phases of the disease, while a normal dose of vitamin D increased neurogenesis during the late phases. Conversely, an early hypovitaminosis D increased the number of amyloid plaques in AD mice while a late hypovitaminosis D impaired neurogenesis in AD and WT mice. The observed in vivo vitamin D-associated increased neurogenesis was partially substantiated by an augmented in vitro proliferation but not an increased differentiation of neural progenitors into neurons. Finally, a sexual dimorphism was observed. Vitamin D supplementation improved the working memory of males and females, when delivered during the pre-symptomatic and symptomatic phases, respectively. Our study establishes that (i) neurogenesis is improved by vitamin D in a male mouse model of AD, in a time-dependent manner, and (ii) cognition is enhanced in a gender-associated way. Additional pre-clinical studies are required to further understand the gender- and time-specific mechanisms of action of vitamin D in AD. This may lead to an adaptation of vitamin D supplementation in relation to patient’s gender and age as well as to the stage of the disease.


Created by admin. Last Modification: Sunday December 2, 2018 15:15:16 GMT-0000 by admin. (Version 19)

Attached files

ID Name Comment Uploaded Size Downloads
10888 Plaque decreased with high dose later in life.jpg admin 23 Nov, 2018 16:47 19.99 Kb 717
10887 More brain cells with early high dose.jpg admin 23 Nov, 2018 16:46 19.75 Kb 735
10886 Memory improved in all mice.jpg admin 23 Nov, 2018 16:46 19.09 Kb 710
10885 Vitamin D Improves Neurogenesis and Cognition.pdf PDF 2018 admin 23 Nov, 2018 12:54 1.46 Mb 325
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