- You can easily improve outcomes of many planned surgeries by increasing vitamin D ahead of time
- Cancer surgery is the only known exception - extra Vitamin D is OK only if doctor reduces the chemo doses
- A loading dose of Vitamin D also improves unplanned hospital admissions
- Improvements include
- Shorter recovery time
- Shorter ICU time
- Reduced deaths – in hospital, next month, next year
- Reduced Sepsis = blood poisoning = infection
- Glutamine and Omega-3 have also been proven to help several traumas/surgeries
- Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
(More on Trauma and Surgery info below)
Learn how Vitamin D is essential for good health
Watch a 5 minute video "Does Less Sun Mean more Disease?"
Browse for other Health Problems and D in left column or here
see also Supplementing and More in the menu at the top of every page
If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Often your specific health problem will also be treated
see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis chemotherapy
Search Vitamin D Life for TBI OR "Traumatic Brain Injury" 798 items as of March 2020
Search Vitamin D Life for cathelecidin OR hCAP18 219 items as of March 2020
Search Vitamin D Life for ICU OR “critical care” OR “intensive care” OR “acute care”
1740 items as of May 2019
Search Vitamin D Life for transplant 794 items as of Jan 2018
The items which are in both Intervention and Trauma/Surgery are listed here
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Surgeries outcomes far better if daily 50,000 IU of vitamin D for a week – Oct 2018
- Knee replacement not helped by 2,000 IU of vitamin D (both too late and too little) – RCT July 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- 18 fewer hospital days if given 500,000 IU of vitamin D while ventilated in ICU – RCT June 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Vitamin D reduces sepsis
Pages in BOTH of the categories: Trauma/Surgery and Loading Dose
- ICU patients greatly helped by Vitamin D loading doses – if gut-friendly – Oct 2020
- Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- 100,000 IU daily of Vitamin D for 5 days increased Hemoglobin in Mechanically Ventilated adults – RCT Jan 2018
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023
- Use of Vitamin D in a trauma surgery - Dr. Matthews on Facebook – Jan 2020
- Surgeries often deplete Vitamin D - 300,000 IU resulted in no benefit (only 22 ng) – Nov 2018
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- ICU adults getting 540,000 IU of Vitamin D were 2X more likely to be alive 30 days later – RCT June 2019
- Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Vitamin D Loading dose - 20,000 IU daily is not enough if obese, etc. (Cancer) great table and chart – Oct 2016
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- VITdAL-ICU - AMA RCT Sept 2014
- Critically ill need vitamin D – how much and which test to use is TBD – Nov 2014
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
- 540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011
- Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily – June 2010
- 600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010
Pages in BOTH of the categories: Trauma/Surgery and Infants/Children
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- PICU children with low vitamin D levels have worse health scores (PRISM-III) – Feb 2020
- Vitamin D levels dropped 42 percent immediately after pediatric cardiac surgery – Dec 2019
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- Candida infections in PICU reduced by Vitamin D in yogurt – RCT Feb 2019
- Children entering ICU with low vitamin D were 3.5 X more likely to have a poor ICU score– Oct 2018
- Critically ill children with low vitamin D: 2.5 X more likely to die or stay 2 days longer - meta-analysis Nov 2017
- Micronutrients (such as Vitamin D) for critically ill children – review Oct 2017
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Vitamin D deficiency in pediatric critical illness: Time to move on from observational studies – Nov 2016
- Low vitamin D in Pediatric ICU – 5 times more ill (morbidity) – Spanish Nov 2016
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- Congenital Heart problems - vitamin D levels drop even lower after surgery, loading dose probably required - thesis 2015
- Infant in ICU much more likely to die if low vitamin D – Nov 2015
- 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
- Hospitalization consumes vitamin D in children – March 2014
- Congenital heart surgery dropped vitamin D levels by 40 percent – July 2013
- Vitamin D deficient children stayed in ICU almost 2 days longer – Sept 2012
Pages in BOTH of the categories: Trauma/Surgery and Mortality
- Cardiac Surgery with low vitamin D increased delirium 1.4X, mortality 1.5X – May 2020
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- Low Vitamin D when entering ICU is deadly (acute kidney injury in this case) – Aug 2017
- Increased Hospital, Sepsis deaths if low vitamin D – March 2014
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Half of Swiss emergency patients had low vitamin D: length of stay, mortality, etc. – May 2016
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- ICU patients 30 percent less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- Radio frequency ablation survival doubled with even modest levels of vitamin D – Feb 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Risk of death within 90 days of ICU decreased by 16 percent for 1 nanogram extra vitamin D – June 2014
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Hospital or ICU death about twice as likely if low vitamin D – March 2014
- 3X more likely to die within 3 months of being in ICU for 2 days if less than 20 ng vitamin D – Sept 2013
- Chance of dying within 1 month of entering hospital is 45 percent higher if low vitamin D – July 2013
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Off topic: Use of ICU in month before death has increased to almost 30 pcnt – Feb 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Critically ill 70 percent more likely to die if vitamin D less than 15ng – Jan 2011
Pages in BOTH of the categories: Trauma/Surgery and Omega-3
- Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019
- Hospitalization costs reduced ~3,000 dollars when intravenous nutrition was augmented with Omega-3 – Aug 2019
- Omega-3 supplements taken before and after surgery actually helped – RCT Nov 2018
- ICU length of stay reduced when supplement with Omega-3 – meta-analysis July 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Omega-3 benefits in surgery and ICU including via IV - March 2016
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016
- Football Brain injuries prevented by Omega-3 – RCT Jan 2016
- Omega-3 should be cost-effective to reduce days in ICU – simulation June 2015
Vitamin D Council
- 45 minute podcast Vitamin D in hospital Nov 2014
- New study offers insight into why low vitamin D levels are associated with adverse outcomes among the critically ill March 2015
Higher levels of Vitamin D ==> Higher levels of cathelecidin (hCAP18)==> fight bacteria
lowest hCAP18 levels had 4.49 increased odds of 90-day mortality
20 Most-visited pages in Trauma/Surgery category in Vitamin D Life
- wiki page:
- ICU patients greatly helped by Vitamin D loading doses – if gut-friendly – Oct 2020
- Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020
- Vitamin D reduces inflammation in critically ill patients – Sept 2020
- Give Vitamin D before all spinal surgeries – no testing needed – June 2020
- Vitamin D reduces trauma injuries in many ways – June 2020
- ICU was 2X less likely for COVID-19 hospitalization if Vitamin D more than 20 ng – July 2020
- Cardiac Surgery with low vitamin D increased delirium 1.4X, mortality 1.5X – May 2020
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- 100,000 IU daily of Vitamin D for 5 days increased Hemoglobin in Mechanically Ventilated adults – RCT Jan 2018
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- PICU children with low vitamin D levels have worse health scores (PRISM-III) – Feb 2020
- Role and Mechanism of Vitamin D in Sepsis (Chinese) – Feb 2020
- Smokers should stop 1 month before surgery W.H.O. – Jan 2020
- Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023
- Use of Vitamin D in a trauma surgery - Dr. Matthews on Facebook – Jan 2020
- 8X more likely to have leaky gut in ICU if low vitamin D - Oct 2019
- Vitamin D levels dropped 42 percent immediately after pediatric cardiac surgery – Dec 2019
- Vitamin D, glutathione, and heat shock protein to treat concussions, etc. – US Patent Dec 2019
- Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019
- Fewer Burn problems if adequate Vitamin D – Less ICU, Hospital, Sepsis (10X) – Dec 2019
- Surgery outcome worse if low vitamin D (lumbar spine surgery this time) – Nov 2019
- 3 additional hospital days after emergency neurosurgery if low vitamin D – Nov 2019
- Stem cell transplant (HSCT) patients are dying due to lack of vitamin D – Oct 2019
- Stem cell transplant (HSCT). death 28 percent less likely for each 10ng higher vitamin D level – Oct 2019
- Surgeries often deplete Vitamin D - 300,000 IU resulted in no benefit (only 22 ng) – Nov 2018
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- Vitamin D before surgery often helps (Thyroidectomy in this case) – Sept 2019
- Hospitalization costs reduced ~3,000 dollars when intravenous nutrition was augmented with Omega-3 – Aug 2019
- Surgical Site Infection 4X more likely if low vitamin D – Aug 2019
- Spinal Cord Injury treated by Vitamin D progesterone combination, etc. – review of trials – Aug 2019
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- Vitamin D being used by sports teams to avoid injuries and improve performance – WSJ Jan 2016
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Following brain surgery Vitamin D injections did not raise blood levels much – RCT June 2019
- ICU adults getting 540,000 IU of Vitamin D were 2X more likely to be alive 30 days later – RCT June 2019
- Vitamin B12 treats Traumatic Brain Injury in mice – April 2019
- Traumatic Brain Injuries routinely treated by Vitamin D, Omega-3, Progesterone and Gluatmine
- Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019
- Vitamin D levels not associated with days in ICU (both short and long term residents had low vitamin D) – May 2019
- Orthopaedic surgery Vitamin D – April 2019
- Burns - will 200,000 IU of vitamin D decrease hospital stay - RCT 2021
- Candida infections in PICU reduced by Vitamin D in yogurt – RCT Feb 2019
- Delirium 24 percent more likely for each 2.5 ng lower vitamin D (313,000 patients) – Feb 2019
- 1,000 IU of vitamin D daily did not help ICU much (no surprise) – Feb 2019
- Foot and Ankle Surgeries should benefit from Vitamin D – Feb 2019
- Vitamin D, trauma, and blacks - Dr. Matthews interview with transcript - Jan 2019
- Vitamin D and critical illness – many questions and unknowns (DBP etc)– Dec 2018
- Omega-3 supplements taken before and after surgery actually helped – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Low vitamin D at ICU admission is associated with cancer, infections, acute respiratory insufficiency and liver failure – Oct 2018
- Before joint replacement surgery low Vitamin D associated with systemic disease – Aug 2018
- Surgeries outcomes far better if daily 50,000 IU of vitamin D for a week – Oct 2018
- Brain injury disability associated with lower vitamin D – Oct 2018
- Anesthesia problems associated with low vitamin D – Oct 2018
- Vitamin D appears essential to survive many critical illnesses - review Oct 2018
- Children entering ICU with low vitamin D were 3.5 X more likely to have a poor ICU score– Oct 2018
- After hip surgery Vitamin D levels dropped by 32 percent – Sept 2018
- Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018
- Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018
- Neurosurgical ICU patients critically low on Vitamin D – Feb 2018
- Off topic: Improving your health BEFORE surgery (prehabilitation) helps your recovery - 2018
- Bed sores in ICU 2.5 X more likely if low vitamin D – Aug 2018
- ICU length of stay reduced when supplement with Omega-3 – meta-analysis July 2018
- Knee replacement not helped by 2,000 IU of vitamin D (both too late and too little) – RCT July 2018
- Only 1600 IU of Vitamin D to be given following knee and hip replacement trial – 2020
- Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Concussion which caused unconsciousness increased risk of Parkinson's by 50 percent (300,000 military) - May 2018
- The effect of vitamin D on different human cells, with emphasis on burns and ICU – April 2018
- All ICU patients with good vitamin D level survived, none who died had a good level – April 2018
- 5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018
- Vitamin D levels might be raised very quickly
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Critically ill dogs with good levels of vitamin D have much better outcomes (humans too) – March 2018
- Postoperative cognitive dysfunction 8 X more likely if low vitamin D – March 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Open Heart Surgery associated with low vitamin D, but not if 150,000 IU before surgery – RCT March 2018
- Hospital Acquired Infection, Mortality, Critically Ill and Vitamin D - 2017
- Trauma with fracture – 2 weeks longer hospital stay if less than 10 ng vitamin D – Jan 2018
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- Vitamin D might reduce suture infection when time-released from nano-structure suture – Nov 2017
- Critically ill children with low vitamin D: 2.5 X more likely to die or stay 2 days longer - meta-analysis Nov 2017
- Omega-3 benefits in surgery and ICU including via IV - March 2016
- Vitamin D deficiency with severe sepsis increased risk of dying by 7.7 X – Nov 2017
- Micronutrients (such as Vitamin D) for critically ill children – review Oct 2017
- Including Vitamin D test results improved 90 day ICU mortality prediction (when will they add Vitamin D to patients) – June 2016
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- Delirium in Hospitalized Older Adults (does not mention low vitamin D relationship) NEJM Oct 2017
- ICU - lots of vitamin D in first week helped the dark skinned - April 2017
- Critical illness – Vitamin D levels start low and then drop for several days – Feb 2018
- Sepsis was present in 6 percent of US adult hospitalizations – JAMA Oct 2017
- Low Vitamin D when entering ICU is deadly (acute kidney injury in this case) – Aug 2017
- Bones helped by Vitamin D, Physical Exercise, etc (this time - Bariatric Surgery) – RCT March 2016
- 300,000 IU Vitamin D injection before brain tumor surgery – RCT to finish Dec 2017
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Vitamin D is Way More Important in Critical Care Than We May Have Recognized - June 2017
- Increased Hospital, Sepsis deaths if low vitamin D – March 2014
- Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017
- Fewest ICU deaths with lowest hCAP 18, but perhaps middle Vitamin D – March 2015
- COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- Vitamin D and critically ill patients (book chapter) – April 2017
- Vitamin D deficiency in pediatric critical illness: Time to move on from observational studies – Nov 2016
- Fewer Complications Following Revision Hip and Knee Arthroplasty in Patients with Normal Vitamin D Levels – March 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Half of Swiss emergency patients had low vitamin D: length of stay, mortality, etc. – May 2016
- Having less than 15 ng of vitamin D increased risk of hospitalization with infection by 2.8 times – April 2016
- Miraculous Vitamin D – recovered from coma in a week – Jan 2017
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- Spinal Surgery patients – almost all have low vitamin D – Nov 2016
- Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016
- Low vitamin D in Pediatric ICU – 5 times more ill (morbidity) – Spanish Nov 2016
- ICU patients 30 percent less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Severe Sepsis associated with very low vitamin D – Sept 2016
- Vitamin D insufficiency increased after hip replacement: – 38% before, 68% the next day – Nov 2016
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Vitamin D Loading dose - 20,000 IU daily is not enough if obese, etc. (Cancer) great table and chart – Oct 2016
- Increasing number of people admitted to a hospital in India have very high vitamin D – Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- Vitamin D should improve rotator cuff surgery success rate – June 2016
- Twice as likely to die during neurological critical care if low vitamin D – July 2016
- 4 fewer days in hospital after hip or knee replacement if good level of vitamin D – June 2016
- 18 fewer hospital days if given 500,000 IU of vitamin D while ventilated in ICU – RCT June 2016
- Cardiac rehabilitation had more power if more than 20 nanograms of vitamin D – April 2015
- Radio frequency ablation survival doubled with even modest levels of vitamin D – Feb 2016
- Football Brain injuries prevented by Omega-3 – RCT Jan 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- Congenital Heart problems - vitamin D levels drop even lower after surgery, loading dose probably required - thesis 2015
- Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015
- Infant in ICU much more likely to die if low vitamin D – Nov 2015
- Surgical ICU – 2.7 X more likely go home if OK vitamin D – Sept 2015
- Risk of death within 90 days of ICU decreased by 16 percent for 1 nanogram extra vitamin D – June 2014
- Critically ill injected with 300,000 IU of vitamin D, 3X more likely to die if PTH did not respond - RCT July 2015
- Omega-3 should be cost-effective to reduce days in ICU – simulation June 2015
- Postoperative adhesions reduced in rats supplemented with vitamin D – RCT May 2015
- ICU death 2X more likely if low vitamin D (sensitivity and selectivity chart) – May 2015
- ICU patients with low Magnesium were 2X more likely to die – June 2014
- Delirium 2.7 X more likely after hip fracture and low vitamin D – May 2015
- ICU death 2X more likely if low Magnesium – March 2015
- Hospitalized cats 8X more likely to die if low vitamin D (Vit. D helps humans too) – May 2015
- Surgical outcomes are better for higher levels of Vitamin D – systematic review May 2015
- Acute respiratory distress – 100 percent of patients were vitamin D deficient– April 2015
- Hospital induced delirium 2X more likely if low vitamin D – April 2015
- 1 in 6 critically ill in India have high levels of vitamin D (100 ng) – March 2015
- 1 in 6 critically ill taking lots of vitamin D (100 ng) – March 2015
- VITdAL-ICU - AMA RCT Sept 2014
- Longer mechanical ventilation times in ICU if lower vitamin D levels – Jan 2015
- Burn patients have little vitamin D and benefit when it is restored
- 1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis Dec 2014
- Superbug (Clostridium difficile) Infections strongly associated with low vitamin D
- Vitamin D and Glutamine resulted in 2.6X reduction in trauma center mortality rate – Dec 2014
- Vitamin D as a modifiable risk factor in critical illness - English and Portuguese March 2014
- Critically ill need vitamin D – how much and which test to use is TBD – Nov 2014
- Acute Rehab. patients 2.3X more likely to have musculoskeletal pain if low vitamin D – Oct 2014
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
- Mild Traumatic Brain Injury reduced by Vitamin D – May 2014
- Pro-inflammatory cytokines cause the 74 percent drop in vitamin D after knee arthroplasty – Feb 2014
- Critically ill patients with low vitamin D were 13X more likely to have a lot of mitrocondrial DNA in blood – Sept 2014
- Prior to Bariatric Surgery 96 percent were vitamin D deficient – July 2014
- When It Comes to Raising Vitamin D Levels, Anesthesiologists Advised—"Don't Be Wimpy!" – Sept 2014
- Chance of death after non-cardiac surgery reduced 2X by Vitamin D – Aug 2014
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Hospital or ICU death about twice as likely if low vitamin D – March 2014
- 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
- Hospitalization consumes vitamin D in children – March 2014
- Soldiers need vitamin D, but levels cut in half in 18 years – March 2014
- Hospital-Acquired Infections 3X more likely after Gastric Bypass if less than 30 ng vitamin D – Feb 2014
- 96 percent vitamin D deficient – destitute asylum seekers and refugees in London – Nov 2012
- More sepsis deaths in those entering hospital with low vitamin D – Jan 2014
- Trauma – 86 percent had less than 30 ng of vitamin D, dark skinned even worse – Jan 2013
- Stayed 3 days longer in geriatric acute care unit if low vitamin D – 2013
- US Army learning about benefits of vitamin D to trauma – Dec 2013
- Vitamin D needed after most spinal surgeries (and before as well) – 2013
- 1 month after plasma exchange vitamin D levels reduced by 40 percent – Oct 2013
- Vitamin D in the ICU: anything new under the sun - Dec 2012
- Deep sedation in ICU reduced cognition even a year later (needed more vitamin D) – Oct 2013
- ICU reduces Vitamin D levels, deregulates PTH - Sept 2013
- 3X more likely to die within 3 months of being in ICU for 2 days if less than 20 ng vitamin D – Sept 2013
- 2X more likely to get hospital infection if low vitamin D (10 ng) when enter – Oct 2013
- Chance of dying within 1 month of entering hospital is 45 percent higher if low vitamin D – July 2013
- No association of cardiac surgery outcome with vitamin D level – they were all low – May 2013
- One issue of Inflammation and Allergy-Drug Targets has vitamin D items behind paywall– June 2013
- Congenital heart surgery dropped vitamin D levels by 40 percent – July 2013
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Low levels of vitamin D prior to spine surgery – March 2013
- Off topic: Use of ICU in month before death has increased to almost 30 pcnt – Feb 2013
- 20 percent of Critically ill in India had undetectable vitamin D, and 62 percent died – Jan 2013
- Sepsis bacteria can be killed by blue as well as UV light – Jan 2013
- Vitamin D decrease during inflammation is probably due to interferons - Oct 2012
- Hypomagnesemia (low Magnesium) is very prevalent in ICU – 1999
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Magnesium may be an important way to treat brain trauma
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- After bone fracture, vitamin D unchanged but 1,25(OH)(2) D decreased – Jan 2013
- Deadly amount of vitamin D speeds up recovery of crushed muscles in rats – Dec 2012
- Higher vitamin D levels associated with fewer vein clots decades later– Jan 2013
- Vitamin D deficient children stayed in ICU almost 2 days longer – Sept 2012
- Hypothesis: Extensive burns reduce vitamin D, which increase bone loss – Nov 2012
- Trauma and surgery
- Will lots of vitamin D help in ICU – RCT protocol Nov 2012
- Plasma exchange cut vitamin D levels in half – June 2012
- Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012
- With just 200 IU vitamin D in intravenous feeds, deficiency results
- Highest vitamin D increases after spine surgery associated with best outcomes – July 2012
- Vitamin D supplementation did not decrease LDL lipids – Ha! June 2012
- Moderate and severe strokes 2X associated with low vitamin D – 2012
- Vitamin D's potential to reduce the risk of hospital-acquired infections – May 2012
- 5 days longer in ICU if low on vitamin D - April 2012
- If you are getting a lung transplant you must have vitamin D - April 2012
- How to reduce hospital infections with vitamin D – April 2012
- Sepsis associated with low vitamin D - April 2012
- Shorter time in ICU if have higher level of vitamin D – April 2012
- ICU patients with pneumonia stay 7 days longer if low vitamin D - Dec 2011
- Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012
- Being vitamin D deficient in the ICU is not good - Feb 2012
- Elderly surgical rehab in Germany - 67 pct have less than 10 ng vitamin D – Jan 2012
- Nursing home residents 2X more likely to die of some surgeries – perhaps lack vitamin D
- Vitamin D levels of critically ill patients reduced 35 pct after blood dilution – Nov 2010
- 20 percent change in vitamin D levels of critically ill during a 24 hour period – Oct 2011
- Critical Care patients need vitamin D
- Septic shock and low vitamin D in children – Oct 2011
- ICU surgical patients with low vitamin D stayed longer and had more sepsis – Dec 2011
- Vitamin D levels low both before and after organ transplant July 2011
- Survive surgery 3X better if overweight – Hypothesis - due to vitamin D released from fat – Nov 2011
- Spinal fusion patients often low on vitamin D - Nov 2011
- CV event 56 percent more likely after vascular surgery if low on vitamin D – Oct 2011
- ICU needs vitamin D - Vitamin D Council Sept 2011
- Vitamin D reduces lung damage due to radiotherapy – Oct 2011
- Fat soluable vitamins decrease quickly after trauma
- Critical Care patients with less than 15 ng vitamin D were 85 percent more likely to die – Sept 2011
- Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011
- Staph infection reduced 50 percent when have more than 30 ng of vitamin D – Aug 2011
- Higher vitamin D helps regain muscle strength after knee surgery – July 2011
- Stem Cell Transplants consume vitamin D – July 2011
- Vitamin D reduces sepsis
- Heart transplant 19 ng vitamin D vs liver transplant 13 ng – April 2009
- MRSA inpatient cost 2X higher if less than 20 ng vitamin D – June 2011
- Knee surgery reduced vitamin D by 40 percent in 2 days – May 2011
- Should stock-up on vitamin D if having surgery due to fragile bones – Jan 2011
- 540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011
- Hardly any children had enough vitamin D before bone surgery – April 2011
- Inflammation or surgery or heart attack decreases measured vitamin D levels – Mar 2011
- Virtually all Bariatric Surgery patients vitamin D deficient – should we routinely supplement – Jan 2011
- Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011
- ICU time is 2X more likely to be longer than 2 days if vitamin D less than 20 ng – Mar 2011
- Virtually all veterans in ICU had vitamin D less than 32 ng – Jan 2011
- Critically ill 70 percent more likely to die if vitamin D less than 15ng – Jan 2011
- Vitamin D helps organ transplant
- Every Thyroidectomy patient should get vitamin D and Calcium – Nov 2010
- Patients low on vitamin D stay in hospital longer after thyroid removal – Dec 2010
- Adding Vitamin D decreased kidney deaths by 4x – Dec 2010
- Noticed bones heal faster when more than 60 ng of vitamin D
- Bypass surgery and vitamin D – Nov 2010
- Stop - Read This Before You Have Orthopedic Surgery - Nov 2010
- 94 percent of women were vitamin D insufficient after earthquake – Aug 2010
- Low vitamin D before orthopedic surgery – dark skin 5X more likely – Oct 2010
- 87 percent of internal medicine patients were severely vitamin D deficient – Aug 2010
- HMOs will save millions of dollars with vitamin D
- Stroke patients show dearth of vitamin D – 2005
- Vitamin D deficiency after gastrointestinal surgery - 2009
- Better total hip replacement if have high vitamin D
- Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily – June 2010
- Gut surgery appears to benefit from vitamin D
- 600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010
- 2X more likely to kill superbug in 1 month with adequate level of vitamin D
- Organ Transplant patients probably need more UV and or vitamin D April 2010
- If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010
See also web
- Screening and Treatment of Vitamin D Deficiency in the Emergency Department – Is There a Benefit for Medical Inpatients? July 2015
Meta-analysis of Vitamin D for ICU - concludes that there is not enough high-quality data is available yet to even test, much less supplement with vitamin D. Publisher charges $30 for PDF - Randomised trials of vitamin D3 for critically ill patients in adults: systematic review and meta-analysis with trial sequential analysis Oct 2016
Publisher wants $40 for the PDF - Vitamin D Supplementation in the Critically Ill: A Systematic Review and Meta-analysis May 2017
RESULTS"Six RCTs (695 patients) met study inclusion. No reduction in mortality was found (P =0.14). No differences in ICU and hospital LOS, infection rate and ventilation days existed. In the subgroup analysis, the oral-enteral group, there was no improvement in mortality (P=0.12) or hospital LOS (P=0.16). Daily doses >300 000 IU did not improve mortality (P=0.12) and ICU LOS (P=0.12)."
Comment by Vitamin D Life: Vitamin D monotherapy is not expected to be useful for ALL ICU situations
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