The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study
Front. Endocrinol., 19 August 2021 | https://doi.org/10.3389/fendo.2021.610893
Milena Cojic1*, Radivoj Kocic2, Aleksandra Klisic1 and Gordana Kocic3
1Primary Health Care Center, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
2Clinic for Endocrinology, Faculty of Medicine, University of Nis, Nis, Serbia
3Institute of Biochemistry, Faculty of Medicine, University of Nis, Nis, Serbia
For over a decade many researchers, like in this study, have been trying to treat Diabetes and other health problems using the Endocrine Society recommendation of 50,000 IU of vitamin D weekly for 3 months. At the end of three months, the vitamin D levels in this study had not yet gotten to even a minimally healthy level.
Success has been found when one or more of the following were done
- Increase the dose for those who are overweight
- People weighing 300 lbs may need 4X more vitamin D than those weighing 150 lbs
- Use a gut-friendly form of vitamin D
- also - topical forms do not need the gut
- Start by first restoring vitamin D levels
- with larger doses for those who have low levels of vitamin D
- Include co-factors needed by individuals– such as Magnesium
- Include Vitamin D Receptor activators - to get the Vitamin D to the cells, not just the blood
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
481 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
23 ; Intervention 52 ; Meta-analysis 34 ; Obesity 29 ; Pregnancy 40 ; T1 (child) 37 ; Omega-3 11 ; Vitamin D Receptor 21 ; Genetics 11 ; Magnesium 19 Click here to see details Download the PDF from Vitamin D Life
Vitamin D deficiency could play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) as it may alter several crucial processes in the development of diabetes and its complications, such as pancreatic insulin secretion, peripheral insulin resistance, persistence of systemic „sterile” inflammation and immune activation. Vitamin D may also have an antioxidant effect through the inhibition of free radicals generation. The reported study was designed with eligible consecutively recruited patients with T2DM on standard metformin therapy (n=130), randomized in 1:1 ratio, considered to have undergone Vitamin D supplementation according to the guidelines proposed by the Endocrine Society, or to have continued with metformin only. The potential benefit was monitored through the influence on glycemia level, glycated haemoglobin (HbA1c), insulin resistance index (calculated as homeostatic model assessment; HOMA-IR), Castelli Risk Index I and Tryglicerides/Thiobarbituric acid-reactive substances (TG/TBARS) Index in a 6-month follow up period. Our study indicates that oral daily doses of vitamin D improve HbA1c levels over the 3-month and 6-month period, followed by a significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given. The effect of vitamin D on HOMA-IR index, malondialdehyde levels and TG/TBARS index was not statistically significant. Further investigation should consider defining the doses of vitamin D in patients with T2DM which may attenuate the oxidative stress risk, the risk of metabolic syndrome and the risk of related cardiovascular events.
Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021Printer Friendly PDF this page! Follow this page for updates328 visitors, last modified 19 Aug, 2021, This page is in the following categories (# of items in each category)