Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis
Nutrients 2016, 8(12), 789; doi:10.3390/nu8120789 (registering DOI)
Min Jung Kim 1, Soo-Nyung Kim 2, Yang Won Lee 1,3,* , Yong Beom Choe 1,3 and Kyu Joong Ahn 1,3
1 Department of Dermatology, Konkuk University School of Medicine, Seoul 05030, Korea
2 Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul 05030, Korea
3 Research Institute of Medical Science, Konkuk University, Seoul 05030, Korea
Dosing should be based on weight etc., not a fixed 1600 IU
Example: Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
Other treatments might include topical vitamin D (probably water-based) and UV
Items in both categories Skin and Inflamation are listed here:
- Eczema (Atopic Dermatitis) treated by 1,600 IU Vitamin D (again) – Meta-analysis Aug 2019
- Increased risk of atopic dermatitis with low vitamin D during pregnancy perhaps due to poor methylation – Oct 2018
- Atopic dermatitis treated by Vitamin D (in dogs too) - RCT Feb 2018
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- Atopic Eczema might be helped by Vitamin D – Review May 2015
- Dermatologists still not convienced that Vitamin D reduces atopic dermatitis – Review Dec 2013
- Eczema 25 percent more likely if low vitamin D– July 2013
- Atopic dermatitis dramatically reduced in Iran with 1600 IU of vitamin D – RCT March 2012
- Atopic Dermatitis and Eczema - many studies
- Atopic dermatitis worse for those with low vitamin D – Nov 2010
See also Vitamin D Life
Download the PDF from Vitamin D Life
Recent literature has highlighted the possible role of vitamin D in atopic dermatitis (AD), and that vitamin D supplementation might help to treat AD. This study determined the relationship between vitamin D level and AD, and assessed the efficacy of vitamin D supplementation. We searched the MEDLINE, EMBASE, and Cochrane databases up to May 2015. Observational studies and randomized controlled trials were included based on the available data on the serum 25-hydroxyvitamin D (25(OH)D) level and quantified data available for severity assessed using the Scoring Atopic Dermatitis (SCORAD) index or Eczema Area and Severity Index (EASI) score. Compared with healthy controls, the serum 25(OH)D level was lower in the AD patients of all ages (standardized mean difference = -2.03 ng/mL; 95% confidence interval (CI) = -2.52 to -0.78), and predominantly in the pediatric AD patients (standardized mean difference = -3.03 ng/mL; 95% CI = -4.76 to -1.29). In addition, the SCORAD index and EASI score decreased after vitamin D supplementation (standardized mean difference = -5.85; 95% CI = -7.66 to -4.05). This meta-analysis showed that serum vitamin D level was lower in the AD patients and vitamin D supplementation could be a new therapeutic option for AD.