Nutr Rev. 2023 Feb 22;nuad006. doi: 10.1093/nutrit/nuad00
Parisa Rouhani 1 2, Elahe Mokhtari 1 2, Keyhan Lotfi 3, Parvane Saneei 2 4
Context: Although some studies have examined the connection between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and preeclampsia (PE) risk, the results were inconsistent.
Objective: A dose-response meta-analysis on epidemiologic investigations was conducted to evaluate the relation of 25(OH)D concentration and PE.
Data source: Electronic databases, including Scopus, MEDLINE (PubMed), the Institute for Scientific Information, Embase, and Google Scholar, were comprehensively search until July 2021.
Data extraction: A total of 65 observational studies evaluating the link between circulating 25(OH)D concentrations and PE were included. The body of evidence was assessed by the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.
Data analysis: Combining 32 effect sizes from 32 prospective studies with 76 394 participants revealed that
- highest vs lowest circulating 25(OH)D concentrations was significantly related to a 33% reduced risk of PE (relative risk [RR], 0.67; 95%CI, 0.54-0.83).
*Subgroup analysis by study design revealed that PE risk has significantly decreased in cohort and case-cohort studies (RR, 0.72; 95%CI, 0.61-0.85), and
- a slight decline was found in nested case-control studies (RR, 0.62; 95%CI, 0.38-1.02).
Dose-response analysis in 27 prospective studies with 73 626 participants illustrated that each 10 ng/mL increment in circulating 25(OH)D concentration led to a 14% reduced incidence of PE (RR, 0.86; 95%CI, 0.83-0.90). A U-shaped significant association in nonlinear dose-response analysis was found between 25(OH)D and PE. A significant inverse association was also found between highest vs lowest circulating 25(OH)D concentration and PE in 32 nonprospective studies with 37 477 participants (odd ratio, 0.37; 95%CI, 0.27-0.52). This inverse association was significant in almost all subgroups, based on different covariates.
Conclusion: This meta-analysis of observational investigations showed blood 25(OH)D levels were negatively related to PE risk, in a dose-response manner.
50+ Vitamin D Life Pregnancy pages with PREECLAMPSIA in title
This list is automatically updated
Items found: 53
| Title | | Modified |
| Vitamin D supplementation decreased the risk of preeclampsia by 39% – meta-analysis Feb 2024 | | 07 Mar, 2024 |
| Preeclampsia reduced by Vitamin D - many studies | | 01 May, 2023 |
| 200 IU of Vitamin D does not prevent preeclampsia – RCT Aug 2012 | | 01 May, 2023 |
| Preeclampsia reduced by 33 percent if high vitamin D – meta-analysis Feb 2023 | | 23 Feb, 2023 |
| Risk of preeclampsia should drop to nearly zero at 60 ng of Vitamin D – July 2022 | | 22 Jul, 2022 |
| Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 | | 31 May, 2022 |
| Low Vitamin D associated with preeclampsia - meta-analysis Feb 2022 | | 24 Mar, 2022 |
| Seasonal variation on preeclampsia is correlated with sunlight intensity - June 2010 | | 28 Oct, 2021 |
| No Preeclampsia during pregnancy if more than 60 ng of vitamin D – RCT July 2013 | | 02 Jul, 2021 |
| Child 49 percent higher risk of being overweight if preeclampsia during pregnancy – Sept 2017 | | 02 Jul, 2021 |
| Hypertension in pregnancy (preeclampsia) more frequent in winter (low vitamin D) – Jan 2015 | | 22 Jun, 2021 |
| Preeclampsia (hypertension while pregnant) varies with season (O.R. 0.57) – June 2021 | | 22 Jun, 2021 |
| Preeclampsia (low vitamin D) doubles the risk of later cardiovascular problems – Sept 2019 | | 07 Oct, 2019 |
| Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019 | | 29 Sep, 2019 |
| Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 | | 12 Sep, 2019 |
| Preeclampsia 2.7 X less likely if 50,000 IU of Vitamin D every 2 weeks – meta-analysis Sept 2019 | | 06 Sep, 2019 |
| Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019 | | 23 Apr, 2019 |
| Preeclampsia 3X more likely if low vitamin D at 25th week – April 2012 | | 20 Feb, 2019 |
| Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013 | | 20 Feb, 2019 |
| Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014 | | 20 Feb, 2019 |
| Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018 | | 20 Feb, 2019 |
| Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017 | | 20 Feb, 2019 |
| Preeclampsia is not reduced by vitamin D (if you ignore vitamin D level, dose size, frequency and duration) – July 2017 | | 20 Feb, 2019 |
| Preeclampsia inversely proportional to serum Magnesium – Oct 2014 | | 20 Feb, 2019 |
| Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016 | | 20 Feb, 2019 |
| Preeclampsia reduced 1.7 X by aspirin (but reduced 7 X by Vitamin D) – Feb 2018 | | 22 Aug, 2018 |
| Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 | | 10 Nov, 2017 |
| Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017 | | 24 Oct, 2017 |
| Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017 | | 08 Sep, 2017 |
| Dark-skined mothers: preeclampsia 12X more likely if gestational hypertension – May 2014 | | 17 Aug, 2017 |
| Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017 | | 17 Jul, 2017 |
| Preeclampsia doubles the risk of mild cognitive impairment – July 2017 | | 05 Jul, 2017 |
| Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016 | | 18 Dec, 2016 |
| Preeclampsia 3.5 times more likely if low vitamin D (affects 348 Vit. D genes) – RCT Nov 2016 | | 15 Nov, 2016 |
| Vitamin D supplementation of all pregnant women (in UK) would be cost effective – just considering preeclampsia – March 2016 | | 09 Jul, 2016 |
| Preeclampsia 4X less likely if vitamin D levels increased by 8 ng during pregnancy – March 2016 | | 05 Apr, 2016 |
| Preeclampsia 2X more likely if low vitamin D, unless adjust for vitamin D factors (BMI, skin color) – Dec 2015 | | 21 Jan, 2016 |
| 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013 | | 16 Jan, 2016 |
| Preeclampsia and eclampsia associated with lower vitamin D, etc. – Sept 2015 | | 13 Nov, 2015 |
| Preeclampsia increased risk of Congenital Heart Defects by 60 percent (vitamin D not mentioned) Oct 2015 | | 28 Oct, 2015 |
| 5,000 IU Vitamin D was not enough to reduce preeclampsia but did help future infant – RCT April 2014 | | 15 Oct, 2015 |
| Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015 | | 15 Oct, 2015 |
| Why preeclampsia is 5X more likely if vitamin D insufficient – Jan 2015 | | 06 Sep, 2015 |
| Preeclampsia – hypothesis as to why vitamin D helps – June 2015 | | 09 Jun, 2015 |
| Preeclampsia was prevented or treated by vitamin D in majority of studies – review May 2015 | | 26 May, 2015 |
| Women with low vitamin D 4X more likely to have preeclampsia in pregnancy – Nov 2010 | | 28 Mar, 2015 |
| 7X increase in early severe preeclampsia associated with low vitamin D – Aug 2012 | | 20 Mar, 2015 |
| High blood pressure during pregnancy (preeclampsia) associated with low vitamin D, c-section – Jan 2015 | | 22 Jan, 2015 |
| Preeclampsia 40 percent less likely if mother had more than 20 ng of vitamin D – Jan 2014 | | 30 Jan, 2014 |
| 2X more likely to have preeclampsia if less than 20 ng of vitamin D – Meta-analysis Jan 2013 | | 11 Jan, 2014 |
| Almost 3X more likely to get preeclampsia if low vitamin D and high PTH– July 2013 | | 15 Sep, 2013 |
| How to reduce preeclampsia - May 2011 | | 19 Apr, 2013 |
| Low vitamin D results in severe preeclampsia and low birth weight – Mar 2011 | | 27 Nov, 2011 |
This list is automatically updated
Items found: 11
| Title | | Modified |
| Vitamin D supplementation decreased the risk of preeclampsia by 39% – meta-analysis Feb 2024 | | 07 Mar, 2024 |
| Preeclampsia reduced by 33 percent if high vitamin D – meta-analysis Feb 2023 | | 23 Feb, 2023 |
| Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 | | 31 May, 2022 |
| Low Vitamin D associated with preeclampsia - meta-analysis Feb 2022 | | 24 Mar, 2022 |
| Preeclampsia 2.7 X less likely if 50,000 IU of Vitamin D every 2 weeks – meta-analysis Sept 2019 | | 06 Sep, 2019 |
| Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013 | | 20 Feb, 2019 |
| Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014 | | 20 Feb, 2019 |
| Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017 | | 24 Oct, 2017 |
| Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017 | | 08 Sep, 2017 |
| 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013 | | 16 Jan, 2016 |
| 2X more likely to have preeclampsia if less than 20 ng of vitamin D – Meta-analysis Jan 2013 | | 11 Jan, 2014 |