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Overview Liver and vitamin D

  • Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
  • Fact: Liver diseases often result in lower levels of vitamin D
  • Fact: Various pain relievers damage the liver function
  • Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
  • Options with a poorly functioning liver appear to be:
  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
  7. Get Calcidiol which does not need the liver
  8. Use Topical Vitamin D - activation by the skin etc does not require the liver

Click on image for ways of getting vitamin D even if Liver is not functioning well

See also Vitamin D Life


Inflammatory diseases: review of vitamin D, with many tables – May 2014 which has a summary table
Most of the people with the diseases have less than 20 ng of vitamin D

See also Web

Should monitor Liver Cirrhosis for Vitamin D, A and Zinc - 2018

An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis.
Ann Hepatol. 2018 Oct 16;17(6):920-932. doi: 10.5604/01.3001.0012.7192.
 Download the PDF from Vitamin D Life

Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. This is a narrative review including the relevant literature for cirrhosis and vitamin D, vitamin A, and zinc deficiencies. Vitamin D deficiency has important effects in cirrhosis, regardless of the cause of chronic liver disease.These effects include associations with fibrosis and outcomes such as infections, hepatocellular carcinoma, and mortality. Vitamin A deficiency is associated with liver disease progression to cirrhosis and clinical decompensation, including occurrence of ascites or hepatic encephalopathy. Zinc deficiency can lead to hepatic encephalopathy and impaired immune function. Such deficiencies correlate with patient survival and disease severity. Caution should be applied when replacing vitamin D, vitamin A, and zinc to avoid toxicity. Identification and appropriate treatment of vitamin and mineral deficiencies in cirrhosis may reduce specific nutritional and cirrhosis-related adverse events. Routine monitoring of vitamin A, vitamin D and zinc levels in cirrhosis should be considered.

Chronic Liver Diseases might be treated by Vitamin D - Dec 2014

New insight of vitamin D in chronic liver diseases
Hepatobiliary Pancreat Dis Int. 2014 Dec;13(6):580-5. PMID: 25475859
Chen EQ1, Shi Y, Tang H.

Although the exact role and mechanisms of vitamin D have not been fully elucidated in chronic liver diseases,
it is potentially beneficial in the treatment of chronic liver diseases.
Further mechanistic studies are needed to validate its clinical application.
 Download the PDF from Vitamin D Life.

Low vitamin D = 2X worse liver cancer prognosis

Severe 25-hydroxyvitamin D deficiency identifies a poor prognosis in patients with hepatocellular carcinoma - a prospective cohort study.
Aliment Pharmacol Ther. 2014 May;39(10):1204-12. doi: 10.1111/apt.12731. Epub 2014 Mar 29.
Finkelmeier F1, Kronenberger B, Köberle V, Bojunga J, Zeuzem S, Trojan J, Piiper A, Waidmann O.

BACKGROUND: Vitamin D is involved in many biological processes. The role of vitamin D in patients with hepatocellular carcinoma (HCC) remains inconclusive, although there is evolving evidence that vitamin D may modulate cancer development and progression.

AIM: To evaluate serum vitamin D as prognostic parameter in HCC, we performed a prospective cohort study.

METHODS: HCC patients were prospectively recruited and 25-hydroxyvitamin D3 (25(OH)D3 ) levels were determined. 25(OH)D3 levels were compared to stages of cirrhosis and HCC stages with nonparametric Kruskal-Wallis tests and Spearman correlations in 200 HCC patients. The association of the 25(OH)D3 levels and overall survival (OS) was assessed in uni- and multivariate Cox regression models.

RESULTS: Two-hundred patients with HCC were included. The mean follow-up time was 322 ± 342 days with a range of 1-1508 days. Nineteen patients underwent liver transplantation and 60 patients died within the observation time. The mean serum 25(OH)D3 concentration was 17 ± 13 ng/mL with a range of 1-72 ng/mL. 25(OH)D3 serum levels negatively correlated with the stage of cirrhosis as well as with stages of HCC. Patients with severe 25(OH)D3 deficiency had the highest mortality risk (hazard ratio 2.225, 95% confidence interval 1.331-3.719, P = 0.002). Furthermore, very low 25(OH)D3 levels were associated with mortality independently from the MELD score and high alpha-Fetoprotein levels (>400 ng/mL) in a multivariate Cox regression model.

CONCLUSIONS: We conclude that 25(OH)D3 deficiency is associated with advanced stages of hepatocellular carcinoma and it is a prognostic indicator for a poor outcome.

Progression of Liver damage


Overview Liver and vitamin D        

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Attached files

ID Name Comment Uploaded Size Downloads
12886 Liver damage percentage.jpg admin 29 Oct, 2019 18:46 37.33 Kb 146
11797 Liver.pdf PDF 2019 admin 23 Apr, 2019 14:04 185.86 Kb 101
11796 Liver 2.jpg admin 23 Apr, 2019 14:03 207.76 Kb 1406
11794 Liver 1.jpg admin 23 Apr, 2019 13:57 280.35 Kb 1009
11793 Cirrhosis.jpg admin 23 Apr, 2019 13:57 93.17 Kb 1124
10853 Liver damage stages.jpg admin 17 Nov, 2018 11:35 40.73 Kb 2162
8118 Vitamin D deficiency in patients with liver cirrhosis.pdf PDF 2016 admin 21 Jun, 2017 16:45 649.52 Kb 531
5074 New insight of vitamin D in chronic liver diseases.pdf PDF 2014 admin 19 Feb, 2015 13:52 287.08 Kb 1943
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