Allergy - Overview

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Allergies and Vitamin D

• Childhood allergy, asthma and eczema associated with repeated low vitamin D tests – Oct 2016
• Overview Asthma and Vitamin D
• All items in Breathing and vitamin D 445 items
• All items in Autoimmune and vitamin D 196 items
• Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
• Vitamin D and allergy to common mold - Aug 2010 Research concludes vitamin D may treat or prevent allergy to common mold
• Immune System response of infants is associated with higher levels of vitamin D – RCT Nov 2014
• Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014
• Allergies and low vitamin D strongly associated with night shift bakers– Sept 2014
• Vitamin D, Vitamin A, or Vitamin E association with allergies and asthma – Feb 2012
• Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014
• Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014
• 2X more allergies if 11th womb week was in Spring – Vitamin D or pollen Oct 2010
• Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012
• Search Vitamin D Life for ALLERGY (CAT OR DOG OR PET OR DANDER) 240 items as of March 2018

Food Allergy

• Peanut and Food allergies prevented by Vitamin D
• 6 year-old children were 5X less likely to have food allergies if supplementing with vitamin D – July 2019
• Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019
• Food allergies and low vitamin D – thymus may be the connection – June 2016
• Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014
• 30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012
• Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
  • Hypothesis: Low vitamin D as a fetus then lots of vitamin D as an infant confuses the body
• Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014
• 3X more allergy to peanuts if child born with low UV – Feb 2011
  

Items in both categories Autoimmune and Infant/Child are listed here:

Food Allergy 5X more likely if low vitamin D – Oct 2014

The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy.
J Pediatr. 2014 Oct;165(4):849-54.e1. doi: 10.1016/j.jpeds.2014.06.058. Epub 2014 Aug 6.
Baek JH1, Shin YH1, Chung IH1, Kim HJ1, Yoo EG1, Yoon JW2, Jee HM1, Chang YE3, Han MY4.
1Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea.
2Myongji General Hospital, Goyang, Korea.
3Department of Food and Nutrition Services, CHA Bundang Medical Center, Seongnam, Korea.
4Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea. Electronic address: drmesh at gmail.com.

OBJECTIVE: To investigate the association between serum vitamin D levels, sensitization to food allergens, and the severity of atopic dermatitis in infants.

STUDY DESIGN: We investigated serum 25-hydroxyvitamin D (25[OH]D) and specific immunoglobulin E levels to common or suspected food allergens in 226 infants with atopic dermatitis or food allergy. The severity of atopic dermatitis by the Scoring Atopic Dermatitis index and amount of vitamin D intake was measured in subcohort children. Sensitization to food allergens was categorized by the number (non-, mono-, and poly-) of sensitized allergens and the degree (undetected-, low-, and high-level) of sensitization.

RESULTS: Significant differences in 25(OH)D levels were found between groups on number (P = .006) and degree (P = .005) of food sensitization. The polysensitization group had significantly lower levels of 25(OH)D than the nonsensitization (P = .001) and monosensitization (P = .023) group. High-level sensitization group had significantly lower 25(OH)D levels compared with undetected (P = .005) and low-level (P = .009) sensitization group. Vitamin D deficiency increased the risk of

• sensitization to food allergens (OR 5.0; 95% CI 1.8-14.1), especially to
• milk (OR 10.4; 95% CI 3.3-32.7) and
• wheat (OR 4.2; 95% CI 1.1-15.8).

In addition, the9% of US adults believe they have a food allergy Scoring Atopic Dermatitis index was independently related to 25(OH)D levels after adjusting for the level of sensitization (adjusted R(2) = 0.112, P = .031).

CONCLUSIONS: Our results suggest that vitamin D deficiency increases the risk of sensitization to food allergens and that atopic dermatitis may be more severe in infants with vitamin D deficiency.

 Download the PDF from Vitamin D Life.

19% of US adults now believe that they have a food allergy - 2019

Prevalence and Severity of Food Allergies Among US Adults - JAMA
 Download the PDF from Vitamin D Life

Seems that they do not consider gluten intolerance to be a food allergy

10X more likely to have multiple food allergies if low vitamin D - Sept 2013

1 page item had the following results

Vitamin D levels and food and environmental allergies in the United States - May 2011

Results from the National Health and Nutrition Examination Survey 2005-2006
The Journal of Allergy and Clinical Immunology, Volume 127, Issue 5 , Pages 1195-1202, May 2011
Shimi Sharief, MD; Sunit Jariwala, MD; Juhi Kumar, MD, MPH; Paul Muntner, PhD; Michal L. Melamed, MD,

Background: Previous research supports a possible link between low vitamin D levels and atopic disease.
However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied.

Objective: We sought to test the association between serum 25-hydroxyvitamin D (25[OH]D) deficiency (<15 ng/mL) and insufficiency (15-29 ng/mL) and allergic sensitization measured by serum IgE levels in a US nationally representative sample of 3136 children and adolescents and 3454 adults in the National Health and Nutrition Examination Survey 2005-2006.

Methods: The association of 25(OH)D deficiency with 17 different allergens was assessed after adjustment for potential confounders, including age; sex; race/ethnicity; obesity, low socioeconomic status; frequency of milk intake; daily hours spent watching television, playing videogames, or using a computer; serum cotinine levels; and vitamin D supplement use.

Results: In children and adolescents allergic sensitization to 11 of 17 allergens was more common in those with 25(OH)D deficiency. Compared with sufficient vitamin D levels of greater than 30 ng/mL, after multivariate adjustment, 25(OH)D levels of less than 15 ng/mL were associated with

• peanut (odds ratio [OR], 2.39; 95% CI, 1.29-4.45),
• ragweed (OR, 1.83; 95% CI, 1.20-2.80), and
• oak (OR, 4.75; 95% CI, 1.53-4.94) allergies (P < .01 for all).

Eight other allergens were associated with 25(OH)D deficiency, with P values of less than .05 but greater than .01.
There were no consistent associations seen between 25(OH)D levels and allergic sensitization in adults.

Conclusion: Vitamin D deficiency is associated with higher levels of IgE sensitization in children and adolescents.
Further research is needed to confirm these findings.

Food allergies are associated with both Vitamin D and Vitamin D genes - 2018

Cellular and molecular mechanisms of vitamin D in food allergy
Journal of cellular and molecular medicine, DOI:10.1111/jcmm.13607
Ashlyn Poole, Yong Song, +2 authors Guicheng Brad Zhang

Food allergies are becoming increasingly prevalent, especially in young children. Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis. Links have been made between variations in sunlight exposure, latitude, birth season and vitamin D status with food allergy risk. Despite the heightened interest in vitamin D in food allergies, it remains unclear by which exact mechanism(s) it acts. An understanding of the roles vitamin D plays within the immune system at the cellular and genetic levels, as well as the interplay between the microbiome and vitamin D, will provide insight into the importance of the vitamin in food allergies. Here, we discuss the effect of vitamin D on immune cell maturation, differentiation and function; microbiome; genetic and epigenetic regulation (eg DNA methylation); and how these processes are implicated in food allergies.
 Download the PDF from Vitamin D Life

RTI 36% more likely if low Vitamin D during pregnancy - meta-analysis - May 2018

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies.

Pediatric allergy and immunology, DOI:10.1111/pai.12876
not on sci-hub as of Jan 2019 but can be read in DeepDive
Rosa M Pacheco-González, L Garcia-Marcos, Eva Morales

BACKGROUND: Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis were conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions.

METHODS: Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function. Random-effects meta-analyses were conducted.

RESULTS: A total of 34 from 547 retrieved articles were included. Increased prenatal exposure to 25(OH)D was inversely associated with risk of RTIs. Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratio was 0.64 (95% CI 0.47, 0.87). A positive borderline association was found for lung function at school age (FEV1 z-score coefficient 0.07, 95% CI -0.01, 0.15). No associations were found for wheeze, asthma, atopic eczema, allergic rhinitis, and allergic sensitization.

CONCLUSION: The introduction of public health measures to tackle vitamin D status in pregnancy may reduce the burden of RTIs in offspring. Current evidence does not support an impact on asthma and allergy.

Gut microbiota, probiotics, and vitamin D - May 2011

Journal of Allergy and Clinical Immunology
Volume 127, Issue 5, May 2011, Pages 1087-1094; doi:10.1016/j.jaci.2011.02.015
Ngoc P. Ly MD, MPHa, Corresponding Author Contact Information, E-mail The Corresponding Author, Augusto Litonjua MD, MPHb, Diane R. Gold MD, MPHb and Juan C. Celedón MD, DrPHc
a Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, Calif
b Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass
c Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pa

Current evidence supports a role for gut colonization in promoting and maintaining a balanced immune response in early life. An altered or less diverse gut microbiota composition has been associated with atopic diseases, obesity, or both. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. However, there has been no fully adequate longitudinal study of the relation between the neonatal gut microbiota and the development of allergic diseases (eg, atopic asthma) and obesity. The emergence of promising experimental studies has led to several clinical trials of probiotics (live bacteria given orally that allow for intestinal colonization) in human subjects. Probiotic trials thus far have failed to show a consistent preventive or therapeutic effect on asthma or obesity. Previous trials of probiotics have been limited by small sample size, short duration of follow-up, or lack of state-of-the art analyses of the gut microbiota. Finally, there is emerging evidence that the vitamin D pathway might be important in gut homeostasis and in signaling between the microbiota and the host. Given the complexity of the gut microbiota, additional research is needed before we can confidently establish whether its manipulation in early life can prevent or treat asthma, obesity, or both.

PDF is at the bottom of this page

Food allergies in children 40 % more likely in urban areas (which have less vitamin D) – Sept 2012

Geographic Variability of Childhood Food Allergy in the United States
CLIN PEDIATR September 2012 vol. 51 no. 9 856-861
Ruchi S. Gupta, MD, MPH1,2; Elizabeth E. Springston, BA1; Bridget Smith, PhD3,4; Manoj R. Warrier, MD5,6; Jacqueline Pongracic, MD1,2; Jane L. Holl, MD, MPH1
1 Northwestern University Feinberg School of Medicine, Chicago, IL, USA
2 Children’s Memorial Hospital, Chicago, IL, USA
3 Loyola Stritch School of Medicine, Maywood, IL, USA
4 Edward Hines Jr VA Hospital, Hines, IL, USA
5 Saint Louis University School of Medicine, Saint Louis, MO, USA
6 Allergy, Asthma and Sinus Care Center, Saint Louis, MO, USA
Ruchi S. Gupta, Children’s Memorial Hospital, 2300 Children’s Plaza, Box 157, Chicago, IL 60640, USA Email: rugupta at childrensmemorial.org

Objective The aim of this study was to describe the distribution of childhood food allergy in the United States.

Methods A randomized survey was administered electronically from June 2009 to February 2010 to adults in US households with at least 1 child younger than 18 years. Data were analyzed as weighted proportions to estimate prevalence and severity of food allergy by geographic location. Multiple logistic regression models were constructed to estimate the association between geographic location and food allergy.

Results Data were analyzed for 38 465 children. Increasing population density corresponded with increasing prevalence, from 6.2% in rural areas (95% confidence interval [CI] = 5.6-6.8) to 9.8% in urban centers (95% CI = 8.6-11.0).

Odds of food allergy were graded, with odds in urban versus rural areas highest (odds ratio OR = 1.7, 95% CI = 1.5-2.0), followed by metropolitan versus rural areas (OR = 1.4, 95% CI = 1.2-1.5), and so on. Significance remained after adjusting for race/ethnicity, gender, age, household income, and latitude.

Conclusions An association between urban/rural status and food allergy prevalence was observed.

See also web

• Vitamin D3 and Allergies from VitaminD3Blog March 2011
  • Mentions several articles and has video of Dr. Daniel A. Searing: Vitamin D Deficiency Linked to Allergies, Asthma in Children
• 5 Ways Americans' Allergies Are Getting Worse Heartland Time Magazine May 2011 - based on Qwest study
  • Overall allergy rates up 6% in 4 years
  • ragweed up 15%
• Study: Living With Pets May Protect Infants From Allergies Heartland Time June 2011
  • Perhaps kids with pets are outdoors more, and thus have higher levels of vitamin d
  • Additional possibility: cat fur (like most animal fur and feathers) has vitamin D - probably some will rub off when petting
• Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization. June 2013
  Risk of food sensitivity increased by 2X if consistently low vitamin D levels
• Allergy in Children in Hand Versus Machine Dishwashing Pediatrics Feb 2015 (nothing about vitamin D)
  2X less likely to have food allergy if dishes were washed by hand, not machine
  lower likelihood of eczema (23% vs. 38%) and not other allergy-related symptoms like asthma,
  this adds to the “hygiene hypothesis,” which includes having pets, eating fish and living on a farm
  researchers note that overcrowded housing, low socioeconomic status and immigration status can also be linked to fewer allergies
• World Allergy Organization decided that ZERO vitamin D should be given during pregnancy or to infants or children - 2016
  •  Download the PDF from Vitamin D Life
• Food allergy 2.2X MORE likely if high vitamin D - 2016 disagrees with all previous studies
  •  Download the PDF from Vitamin D Life
  
  Seasonal Allergies in Austin, Texas - nothing about Vitamin D
  
• Why the World Is Becoming More Allergic to Food BBC Sept 2020
  • "Food allergy now affects about 7% of children in the UK and 9% of those in Australia, for example. "
  • "For example, there was a five-fold increase in peanut allergies in the UK between 1995 and 2016."
  • "Migrants appear to show a higher prevalence of asthma and food allergy in their adopted country"
    • Note: Migrants tend to have darker skins and are going to countries far from Equator
  • Vitamin D deficiency is mentioned as a strong possibility
  • One of their references is on Vitamin D Life
    • Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014

106+ Vitamin D Life pages with ALLERG in title

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