Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020

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Vitamin D Receptor can limit vitamin D from getting to cells

Vitamin D Receptor is associated in over 58 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activators

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Osteoporosis and Vitamin D Receptor (11 studies as of Nov 2021)

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Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies - Nov

Genes & Nutrition volume 15, Article number: 20 (2020)
Jun Long Liao, Qiang Qin, Yong Sheng Zhou, Ru Ping Ma, He Chao Zhou, Mao Rong Gu, Yun Ping Feng, Bo Yuan Wang & Ling Yang
 Download the PDF from Vitamin D Life

Objective
This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women.

Materials and methods
The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.

Results
4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians.

Conclusion
The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women.

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Association Between Vitamin D Receptor BsmI, FokI, and Cdx2 Polymorphisms and Osteoporosis Risk: An Updated Meta-Analysis - July

Biosci Rep. 2020 Jul 6;BSR20201200. doi: 10.1042/BSR20201200
Bin Chen 1, Wang-Fa Zhu 1, Yi-Yang Mu 1, Biao Liu 1, Hong-Zhuo Li 2, Xiao-Feng He 3
 Download the PDF from Vitamin D Life
Background: Many studies have reported the association between vitamin D receptor (VDR) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze VDR BsmI, FokI, and Cdx2 polymorphisms on osteoporosis risk. However, they did not evaluate the reliability of statistically significant associations. Furthermore, a lot of new articles have been published on these themes, and therefore an updated meta-analysis was performed to further explore these issues.

Objectives: To explore the association between VDR BsmI, FokI, and Cdx2 polymorphisms polymorphisms and osteoporosis risk.

Methods: The odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to evaluate the association between VDR BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk. To evaluate the credibility of statistically significant associations, we applied the false-positive report probabilities (FPRP) test and the Venice criteria.

Results: Overall, statistically significantly increased osteoporosis risk was found in Indians and women for VDR FokI polymorphism. Statistically significantly decreased osteoporosis risk was found in West Asians for VDR BsmI polymorphism. However, when we performed an sensitivity analysis after excluding low quality and HWD studies, significantly decreased osteoporosis risk was only found in overall population for VDR BsmI polymorphism.

Further, less-credible positive results were identified when we evaluated the credibility of positive results.</p> Conclusion: These positive findings should be interpreted with caution and indicate that significant association may most likely result from less-credible, rather than from true associations or biological factors on the VDR BsmI and FokI polymorphisms with osteoporosis risk.

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The association between vitamin D receptor FokI gene polymorphism and osteoporosis in postmenopausal women: a meta-analysis - June

Climacteric https://doi.org/10.1080/13697137.2020.1775806
S. WangORCID Icon,Z. Ai,M. Song,P. Yan,J. Li &S. Wang
Received 30 Aug 2019, Accepted 22 May 2020, Published online: 18 Jun 2020

Objective: This study aimed to quantitatively summarize the evidence for vitamin D receptor (VDR) FokI gene polymorphism and osteoporosis risk in Caucasian and Asian postmenopausal women.

Materials and methods: The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case–control studies containing available genotype frequencies for F/f were chosen, and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.

Results: In total, 3349 osteoporosis cases and 3202 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR FokI gene polymorphism and postmenopausal osteoporosis susceptibility in Asian subjects (

• additive model: OR = 1.529, 95% CI 1.053–2.219, p = 0.026;
• dominant model: OR 2.711, 95% CI 1.693–4.342 p < 0.001;
• co-dominant model: ff vs. FF, OR 2.796, 95% CI 1.439–5.433 p = 0.002),

and we failed to find any significant relationship in Caucasian populations.

Conclusion: The present meta-analysis suggests that the VDR FokI genotype is associated with increased risk of osteoporosis in Asian women but not in Caucasian women. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR FokI polymorphism and osteoporosis.

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