176 items in Vitamin D Binding Protein categorySee also Vitamin D Receptor Genetics CYP27B1
Did you know?
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Increased
Risk Health Problem 11 X Preeclampsia 6.5X T1D in SA Blacks 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2.8 X MS 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility
VDBP is NOT directly detected by vitamin D blood tests
MS and Vitamin D Binding Protein:
- Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015
- Late-stage MS associated with protein in spinal cord which blocks vitamin D – Jan 2013
TB and Vitamin D Binding Protein:
- Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021
- Tuberculosis not treated by monthly 140,000 IU (Vitamin D binding protein problem) – RCT Sept 2017
- TB lowers vitamin D, then HIV lowers it even more - 2014
- Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014
Breathing and Vitamin D Binding Protein:
- Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014
- COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019
- COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015
- Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
- Vitamin D Binding Protein, And Airflow In COPD - April 2012
- Genetic link found between vitamin D and COPD – June 2010
- How vitamin D helps the lung via vitamin D-binding protein - May 2010
Infant-Child and Vitamin D Binding Protein:
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018
- Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
Pregnancy and Vitamin D Binding Protein:
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms
—The Risk of Malignant Tumors and Other Diseases - Oct 2020 PDF
- wiki page:
- The potential role of vitamin D binding protein in kidney disease: a comprehensive review – Jan 2024
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies
- Many genes can restrict Vitamin D from getting to the cells – Aug 2023
- Vitamin D and it’s related genes regulate the immune system – Aug 2023
- Melanoma death risk 0.63 X lower if poor Vitamin D Binding Gene – July 2023
- 12 Vitamin D genes (Most are not noticed by blood test) – Sept 2021
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
- Response to Vitamin D - many studies
- Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review Dec 2022
- Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022
- Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes) Sept 2022
- 10,000 years of gene changes: increasing many health problems, 2 Vitamin D changes, – Aug 2022
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Some COVID hospitalizations are due to poor Vitamin D genes (Binding Protein in this commentary) – June 2022
- Vitamin D genes – Review June 2022
- Vitamin D metabolism and genes as of Nov 2019
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Poor vision associated with poor Vitamin D or poor Vit. D genes – June 2022
- Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization – May 2022
- Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D Binding Protein may affect immune system dendritic cells – March 2022
- Poor Vitamin D Binding Protein Genes increase the risk of various diseases – Jan 2022
- Lower vitamin D associated with several new genes (Korea GWAS) – Dec 2021
- Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021
- Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Familial Mediterranean Fever is associated with poor Vitamin D Binding Protein – Nov 2020
- Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020
- Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Colorectal Cancer death 2.1X more likely if poor Vitamin D plus poor Vitamin D Binding protein – May 2020
- Vitamin D genes vary with UVB in Europe, Africa, Asia – March 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- 2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020
- Sweat types, folate, binding protein, lighter skin in females and Vitamin D – Jan 2020
- Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020
- Does survival of the less fit mean less health (poor genes may be inherited)
- A poor Vitamin D Binding protein can confirm various clinical diagnoses - Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
- Kidney Cancer 4X more likely if poor Vitamin D Binding Protein (5X in previous study) – Oct 2019
- Vitamin D Binding Protein Review - Oct 2019
Low response to Vitamin D can be improved in many ways
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies
- Reasons for low response to vitamin D
See also web
- Meta-analysis of vitamin D-binding protein and cancer risk Sept 2015
- "Results: We found a borderline decrease in cancer risk for subjects with high compared to low levels of DBP"
- "We included 28 independent studies concerning: basal cell carcinoma, bladder, breast, colon-rectum, endometrium, liver, esophagus, stomach, melanoma, pancreas, prostate and kidney. "
Studies of VDBP and diseases: Pregnancy 10, Skin - Dark 8, Breathing 7, Infant-Child 7, Multiple Sclerosis 6, Virus 6, Cardiovascular 6, Diabetes 5, Autoimmune 4, Cancer - Other 4, Obesity 4, Tuberculosis 4 – Jan 2024
Vitamin D Binding Protein 33517 visitors, last modified 28 Jan, 2024,
Printer Friendly Follow this page for updates This page is in the following categories (# of items in each category)
See also Vitamin D Receptor Genetics CYP27B1
Did you know?
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
| Increased Risk | Health Problem |
| 11 X | Preeclampsia |
| 6.5X | T1D in SA Blacks |
| 6 X | Food Allergy |
| 5 X | PTSD |
| 4 X, 5X | Kidney Cancer |
| 4 X | Poor Response to Oral Vitamin D |
| 3 X | Ear infection |
| 2.8 X | MS |
| 2 X | Colorectal Cancer |
| 2 X | Prostate Cancer -in those with dark skins |
| 1.3 X | Infertility |
VDBP is NOT directly detected by vitamin D blood tests
MS and Vitamin D Binding Protein:
- Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015
- Late-stage MS associated with protein in spinal cord which blocks vitamin D – Jan 2013
TB and Vitamin D Binding Protein:
- Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021
- Tuberculosis not treated by monthly 140,000 IU (Vitamin D binding protein problem) – RCT Sept 2017
- TB lowers vitamin D, then HIV lowers it even more - 2014
- Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014
Breathing and Vitamin D Binding Protein:
- Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014
- COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019
- COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015
- Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
- Vitamin D Binding Protein, And Airflow In COPD - April 2012
- Genetic link found between vitamin D and COPD – June 2010
- How vitamin D helps the lung via vitamin D-binding protein - May 2010
Infant-Child and Vitamin D Binding Protein:
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018
- Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
Pregnancy and Vitamin D Binding Protein:
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms
—The Risk of Malignant Tumors and Other Diseases - Oct 2020 PDF
- wiki page:
- The potential role of vitamin D binding protein in kidney disease: a comprehensive review – Jan 2024
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies
- Many genes can restrict Vitamin D from getting to the cells – Aug 2023
- Vitamin D and it’s related genes regulate the immune system – Aug 2023
- Melanoma death risk 0.63 X lower if poor Vitamin D Binding Gene – July 2023
- 12 Vitamin D genes (Most are not noticed by blood test) – Sept 2021
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
- Response to Vitamin D - many studies
- Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review Dec 2022
- Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022
- Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes) Sept 2022
- 10,000 years of gene changes: increasing many health problems, 2 Vitamin D changes, – Aug 2022
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Some COVID hospitalizations are due to poor Vitamin D genes (Binding Protein in this commentary) – June 2022
- Vitamin D genes – Review June 2022
- Vitamin D metabolism and genes as of Nov 2019
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Poor vision associated with poor Vitamin D or poor Vit. D genes – June 2022
- Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization – May 2022
- Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D Binding Protein may affect immune system dendritic cells – March 2022
- Poor Vitamin D Binding Protein Genes increase the risk of various diseases – Jan 2022
- Lower vitamin D associated with several new genes (Korea GWAS) – Dec 2021
- Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021
- Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Familial Mediterranean Fever is associated with poor Vitamin D Binding Protein – Nov 2020
- Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020
- Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Colorectal Cancer death 2.1X more likely if poor Vitamin D plus poor Vitamin D Binding protein – May 2020
- Vitamin D genes vary with UVB in Europe, Africa, Asia – March 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- 2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020
- Sweat types, folate, binding protein, lighter skin in females and Vitamin D – Jan 2020
- Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020
- Does survival of the less fit mean less health (poor genes may be inherited)
- A poor Vitamin D Binding protein can confirm various clinical diagnoses - Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
- Kidney Cancer 4X more likely if poor Vitamin D Binding Protein (5X in previous study) – Oct 2019
- Vitamin D Binding Protein Review - Oct 2019
Low response to Vitamin D can be improved in many ways
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies
- Reasons for low response to vitamin D
See also web
- Meta-analysis of vitamin D-binding protein and cancer risk Sept 2015
- "Results: We found a borderline decrease in cancer risk for subjects with high compared to low levels of DBP"
- "We included 28 independent studies concerning: basal cell carcinoma, bladder, breast, colon-rectum, endometrium, liver, esophagus, stomach, melanoma, pancreas, prostate and kidney. "
Studies of VDBP and diseases: Pregnancy 10, Skin - Dark 8, Breathing 7, Infant-Child 7, Multiple Sclerosis 6, Virus 6, Cardiovascular 6, Diabetes 5, Autoimmune 4, Cancer - Other 4, Obesity 4, Tuberculosis 4 – Jan 2024
Vitamin D Binding Protein
Printer Friendly Follow this page for updates
| 33517 visitors, last modified 28 Jan, 2024, |
This page is in the following categories (# of items in each category)