Some drugs change potency when Vitamin D is increased (increase in a hormone)

Drug dosages were established for people with < 30 ng of Vitamin D

1) Increased D ==> Increases drug potency ==>sometimes increases risk of death
2) Increased D ==> Decreases drug potency ==> sometimes increases risk of death

Increasing vitamin D substantially INCREASES the potency of various medications

• Good: 10X reduction in side-effects of Flu vaccinations
• Bad: Vitamin D increases the potency of chemotherapy
  • which can be deadly if the doctor does not decrease the Chemo dose

---

• Review of vitamin D interaction with drugs – Jan 2014
  • Vitamin D ==> increase some statins
• Drug–Vitamin D Interactions, A Systematic Review – Jan 2013
• Extensive review of influence of drugs on vitamin D and Calcium – April 2012
• Vitamin D interactions with drugs – Oct 2011
• On-line survey of drug uses and side effects – including vitamin D
• Is too much vitamin D bad – possible causes and cures drug potency, etc.
• Interactions with Vitamin D category listing has 102 items along with related searches

---

Increasing vitamin D substantially DECREASES the potency of various medications

• atorvastatin, thiazide diuretic,

---

Increased drug ==> Decreased Vitamin D: happens far more frequently than 1) or 2) above

---

Note: Most of the mortality increases due to high vitamin D have occurred among the elderly
   elderly take an average of 6 prescription drugs
     the doses were established for people who had low levels of vitamin D

• Is too much vitamin D bad – possible causes and cures
• Even if a J curve exists, it is 50X better to give vitamin D than not give it – May 2013
• Increased chance of death if enter hospital with vitamin D greater than 60 ng (u-shaped) – April 2014
• Mortality increased with highest levels of vitamin D – article and 4 letters Aug 2012

---

Speculation: Increased Vitamin D increases the interaction between two drugs which a person is taking

That is:
Drug A + Drug B + LOW level of Vitamin D ==> no problem
But, Drug A + Drug B + HIGH level of Vitamin D ==> a problem