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Meta-analysis of Vitamin D

641 Meta-analyses

See also Overview Meta-analysis of Vitamin D
Unfortunately, a meta-analysis will frequently fail to consider one or more of the following

  1. Dose size (Some gave the same importance to 40 IU as 10,000 IU)
  2. Dose frequency (Some ignore differences between daily, weekly, monthly, and annual dosing)
  3. Duration, (Some gave same importance to 4 weeks as 4 years)
       It takes 3 to 12 months for vitamin D levels to come to a new plateau
       and it often takes months for the body to then utilize it
  4. Pre-existing Vitamin D blood level
       adding vitamin D does not provide much benefit if person alrady has a good level
  5. Cofactors (Most meta-analyses ignore the importance of Magnesium, Omega-3, Vitamin K2, etc)
  6. Type of Vitamin D - D3 far better than D2
  7. Those with poor guts need a different type of vitamin D
  8. Those who are Obese need 2.5 X more vitamin D
  9. Many drugs, such as statins deplete vitamin D or the Magnesium needed by Vitamin D
  10. For some health problems pulsed vitamin D, not daily, is far better (gets over possible Vitamin D receptor limitation)

See also Proof that Vitamin D Works

See also All items in category Intervention Vitamin D 799 items

See also Clinical Trials of vitamin D can have “biological flaws” – Jan 2015
See also Nice description of Meta-Analysis in Scientific American Jan 2014
See also The Misuse of Meta-analysis in Nutrition Research JAMA Sept 2017
". . . they have mixed apples and oranges—and sometimes “apples, lice, and killer whales”—yielding meaningless conclusions"
"In a 2007 review of 111 industry-funded (nutrition) studies, funding source was significantly related to study conclusions"

Vitamin D Life Comment on Scientific American article

It does not mention the major problems of Vitamin D Meta-analyses.
1) Dose sizes are ignored: Studies assume benefit from 400 IU is the same as for 4,000 IU
2) Durations are ignored: Studies assume benefit of 1 month dosing is the same as 1 year dosing
3) Existing Vitamin D levels are often ignored.
  Studies ignore that a 20 ng addition to a 10 ng person has vastly more benefit than a 20 ng addition to a 40 ng person
A rare example of a good meta-analysis is: one on depression - April 2014

Really great medical studies do not blindly give a single supplement/drug to a group, but rather treat the patients as individuals and provide extra Magnesium, Vitamin K2, Omega-3, Vitamin C, etc as needed. These studies, which have the best results, are not Random Controlled Trials and are virtually never included in a meta-analysis.

Likewise, the trials which give vitamin D to an entire country, or to all of the patients (immoral not to do so) are never considered by any meta-analysis

Vitamin D has climbed the pyramid for decades, but has not yet reached the top

Vitamin D Pyramid

International prospective register of on-going systematic reviews: 569 reviews of Vitamin D as of March 2020

PROSPERO

Intervention - Vitamin D includes the following:


Studies in Vitamin D Life

Year Randomized
Controlled
Trials
Interventions Meta-
analyses
2022900+700+ 600+
2017- 4852
2015698235
2012413839

Note: Govt recommendations in 2015 often ignored data after 2011


Vitamin D Life - Vitamin D meta-analyses for different health problems

Number of Meta-analyses per health problem
ADHD7, Autism7, Autoimmune5, Back pain5, Bone -8, Breathing35, Cancer - Bladder5, Cancer - Breast24, Cancer - Colon25, Cancer - Liver4, Cancer - Lung7, Cancer - Lymphoma4, Cancer - Pancreatic4, Cancer - Prostate8, Cancer16, Cardiovascular38, Cognitive22, Depression16, Diabetes38, Falls and Fractures23, Fertility and sperm6, Genetics4, Gut9, Hypertension22, Infant-Child23, Inflammation11, Kidney12, Liver4, Metabolic Syndrome5, Mortality 28, Multiple Sclerosis13, Obesity8, Osteoarthritis4, Osteoporosis9, Pain - chronic5, Parkinson12, Pregnancy51, Psoriasis6, Rheumatoid Arthritis8, Seniors13, Skin8, Sleep4, Sports11, Stroke8, Thyroid and parathyroid5, Trauma and surgery19, Tuberculosis14, UV and Vitamin D4, Virus37, Vision6, Women7, Youth4


20 Most-visited pages in Meta-analysis category in Vitamin D Life

Id Page Hits Last modification Creator Categories
88 800 IU of vitamin D3 prevents fractures - Mar 2010 2489
20 Feb, 2011 03:56
admin Bone - Health
Meta-analysis of Vitamin D
96 800 IU vitamin D reduces falls - Dec 2009 5261
24 Jun, 2012 00:05
admin Meta-analysis of Vitamin D
Falls and Fractures
238 Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010 2589
12 May, 2010 12:55
admin Cancer - Breast
Meta-analysis of Vitamin D
246 Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010 4024
19 Jul, 2012 15:05
admin Cancer - Breast
Meta-analysis of Vitamin D
272 Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010 3644
17 Jan, 2011 12:56
admin Cancer - Colon
Cancer - Breast
Cancer - Prostate
Meta-analysis of Vitamin D
275 Random Controlled Trials and Meta-Analysis in PubMed 2008
19 May, 2010 22:03
admin Technical D
Meta-analysis of Vitamin D
434 Cochrane review finds that Vitamin D and Calcium treat osteoporosis – Feb 2010 7582
07 Aug, 2015 20:08
admin Osteoporosis
Kidney Stones
Meta-analysis of Vitamin D
486 Meta-analysis of falls and 800+ IU of vitamin D found good results – June 2010 3513
24 Jun, 2012 00:18
admin Meta-analysis of Vitamin D
Falls and Fractures
528 Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010 4763
13 Apr, 2013 15:13
admin Cancer - Colon
Cancer
Meta-analysis of Vitamin D
573 Effectiveness and Safety of Vitamin D in Relation to Bone Health - 2007 3176
06 Jul, 2010 13:03
admin Bone - Health
Meta-analysis of Vitamin D
574 Vitamin D and mortality a meta-analysis of RCT - 2008 4542
06 Jul, 2010 13:09
admin Mortality and D
Meta-analysis of Vitamin D
601 20 year review concludes that Vitamin D reduce ageing – July 2010 3438
07 Mar, 2012 21:58
admin Seniors
Meta-analysis of Vitamin D
618 1000 IU minimum to decrease falls and fractures Swiss - 2009 8871
24 Jun, 2012 00:03
admin Meta-analysis of Vitamin D
Falls and Fractures
723 TB and vitamin D updated review and meta-analysis – plays a role Jan 2010 3976
09 Aug, 2010 13:26
admin Tuberculosis
Meta-analysis of Vitamin D
725 TB associated with low vitamin D in a review and meta-analysis – 2008 3436
09 Aug, 2010 13:31
admin Tuberculosis
Meta-analysis of Vitamin D
830 Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010 4288
30 Aug, 2010 15:35
admin Cancer - Breast
Meta-analysis of Vitamin D
905 Hip fractures in India - editorial with recommendation - Sept 2010 8834
06 Jul, 2012 21:27
admin How much Vitamin D
Osteoporosis
Meta-analysis of Vitamin D
917 Meta-analysis not find low vitamin D years before breast cancer – Aug 2010 5008
10 Sep, 2010 12:15
admin Cancer - Breast
Meta-analysis of Vitamin D
934 Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010 4152
14 Sep, 2010 02:02
admin Seniors
Meta-analysis of Vitamin D
939 Vitamin D is not a vitamin nor an anti-oxidant – Sept 2010 5163
05 Dec, 2010 13:05
admin About D - more info.
Overview for doctors
Meta-analysis of Vitamin D

All of the articles in Meta-Analysis - sorted by date


Short URL =https://is.gd/MetaD

Meta-analysis of Vitamin D        
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