Loading...
 
Toggle Health Problems and D

Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014

Diabetologia, DOI 10.1007/s00125-014-3293-x
Z. Asemi: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I. R. Iran
M. Karamali: Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
A. Esmaillzadeh (*)
Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran e-mail: Esmaillzadeh at hlth.mui.ac.ir

Aims/hypothesis This study was designed to assess the effects of calcium and vitamin D supplementation on the metabolic status of pregnant women with gestational diabetes mellitus (GDM).

Methods This randomised placebo-controlled trial was performed at maternity clinics affiliated to Kashan University of Medical Sciences, Kashan, Iran. Participants were 56 women with GDM at 24-28 weeks' gestation (18 to 40 years of age). Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo. All study participants were blinded to group assignment. Individuals in the calcium-vitamin D group (n=28) received 1,000 mg calcium per day and a 50,000 U vitamin D3 pearl twice during the study (at study baseline and on day 21 of the intervention), and those in the placebo group (n=28) received two placebos at the mentioned times. Fasting blood samples were taken at study baseline and after 6 weeks of intervention.

Results The study was completed by 51 participants (calcium-vitamin D n=25, placebo n=26). However, as the analysis was based on an intention-to-treat approach, all 56 women with GDM (28 in each group) were included in the final analysis. After the administration of calcium plus vitamin D supplements, we observed a significant reduction in fasting plasma glucose (-0.89±0.69 vs +0.26±0.92 mmol/l, p<0.001), serum insulin levels (-13.55±35.25 vs +9.17± 38.50 pmol/l, p=0.02) and HOMA-IR (—0.91±1.18 vs + 0.63±2.01, p=0.001) and a significant increase in QUICKI (+0.02±0.03 vs —0.002±0.02, p=0.003) compared with placebo. In addition, a significant reduction in serum LDL-cholesterol (—0.23±0.79 vs +0.26±0.74 mmol/l, p= 0.02) and total cholesterol: HDL-cholesterol ratio (—0.49± 1.09 vs +0.18±0.37, p=0.003) and a significant elevation in HDL-cholesterol levels (+0.15±0.25 vs —0.02±0.24 mmol/l, p=0.01) was seen after intervention in the calcium-vitamin D group compared with placebo. In addition, calcium plus vitamin D supplementation resulted in a significant increase in GSH (+51.14±131.64 vs —47.27±203.63 mol/l,p=0.03) and prevented a rise in MDA levels (+0.06±0.66 vs +0.93± 2.00 mol/l, p=0.03) compared with placebo.

Conclusions/interpretation Calcium plus vitamin D supplementation in women with GDM had beneficial effects on their metabolic profile.

Trial registration www.irct.ir IRCT201311205623N11
Funding The study was supported by a grant (no. 92110) from Kashan University of Medical Sciences.

Changes after 42 days

Vitamin D given on day 0 and day 21
Image
Image
Image
Image


 Download the PDF from Vitamin D Life

See also Vitamin D Life

Pages listed in BOTH the categories Diabetes and Pregnancy


See also web

Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014        
140501 visitors, last modified 16 Apr, 2019,
Printer Friendly PDF this page! Follow this page for updates

Attached files

ID Name Comment Uploaded Size Downloads
5113 Gestational Diabetes then later diabetes.pdf PDF 2015 admin 02 Mar, 2015 18:55 972.36 Kb 2568
4076 GDM4.jpg admin 26 Jun, 2014 15:31 60.07 Kb 3610
4075 GDM3.jpg admin 26 Jun, 2014 15:31 29.59 Kb 3377
4074 GDM2.jpg admin 26 Jun, 2014 15:31 68.32 Kb 3729
4073 GDM1.jpg admin 26 Jun, 2014 15:30 68.83 Kb 3938
4071 GDM.pdf PDF 2014 admin 26 Jun, 2014 15:17 213.35 Kb 2426
See any problem with this page? Report it (FINALLY WORKS)