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- Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D
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Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D
Biomedicine & Pharmacotherapy https://doi.org/10.1016/j.biopha.2022.112965
Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel López-Wolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero, Mayte Coiras – Multidisciplinary Group of Study of COVID-19 (MGS-COVID)1 MadridHighlights
- Treatment with 10,000 IU/day of cholecalciferol was safe during severe COVID-19.
- Anti-inflammatory cytokine IL-10 was significantly increased in 10,000 IU/day group.
- Individuals who received 10,000 IU/day of cholecalciferol showed increased CD4 count.
- Individuals with ARDS in 10,000 IU/day group stayed at the hospital less time.
- The 10,000 IU/day group showed increased antiviral cytotoxic activity.
Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.8 ng/mL (SD: 6.18) to test antiviral efficacy, tolerance and safety of 10,000 IU/day of cholecalciferol (vitamin D3) for 14 days, in comparison with 2,000 IU/day.
After supplementation, mean serum 25(OH)D levels increased to- 19 ng/mL on average in 2,000 IU/day versus
- 29 ng/mL in 10,000 IU/day group (p <0.0001).
Although levels of inflammatory cytokines were not modified by treatment with 10,000 IU/day, there was an increase of anti-inflammatory cytokine IL-10 and higher levels of CD4+ T cells, with predominance of T central memory subpopulation.
Cytotoxic response against pseudotyped SARS-CoV-2 infected cells was increased more than 4-fold in patients who received 10,000 IU/day. Moreover, levels of IFN? were significantly higher in this group.Beneficial effect of supplementation with 10,000 IU/day was also observed in participants who developed ARDS and stayed at the hospital for 8.0 days, whereas those who received 2,000 IU/day stayed for 29.2 days (p=0.0381). Administration of high doses of vitamin D3 as adjuvant of the standard care treatment during hospitalization for COVID-19 may improve the inflammatory environment and cytotoxic response against pseudotyped SARS-CoV-2 infected cells, shortening the hospital stay and, possibly, improving the prognosis.
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The inclusion criteria for the participants in the study were being adults (>18 years old) hospitalized for at least seven days from the onset of COVID-19 symptoms, which is when usually began the inflammatory phase, with a diagnosis of pneumonia due to COVID-19Speculation:
No hospitalization if had gotten high dose vitamin D at COVID symptom onset
Vitamin D Life: Take lots of Vitamin D at first signs of COVIDthanks to Gustavo Bellini for pointing out this study
VitaminDwiki- Items in both categories Virus and Intervention (
43 items) This list is automatically updated
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- COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT – July 2022
- Small Vitamin D doses for a short time never help (not improve vaccination in this case) – RCT Sept 2022
- The challenges of a Vitamin D RCT – too many already taking it, etc. – Martineau Sept 2022
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- COVID hospital deaths reduced 2X by 8 days of UVB – pilot RCT May 2022
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- 4X less likely to get COVID following 4,000 IU daily for a month – RCT April 2022
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- Group achieving 30 ng (vs 26 ng) were 2X less likely to get COVID symptoms - RCT Jan 2022
- Tested positive for COVID, taking probiotics stopped symptoms 5 days sooner - RCT Jan 2022
- Vitamin D given slowly in hospital did not fight COVID-19 much - Nov 2021
- Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT Oct 2021
- COVID-19 appears reduced by Resveratrol plus 100K IU of vitamin D – Small RCT Sept 2021
- Vitamin D trial for COVID-19 – using their patented slow-release form – Aug 2021
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- calcifediol rct
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- Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014
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- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Influenza A: 5X reduction in first month (only) with 2,000 IU of vitamin D– RCT July 2014
Vitamin D Life – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the Vitamin D Life COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Items found: 7721 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 20222494 visitors, last modified 18 Apr, 2022, This page is in the following categories (# of items in each category)Attached files
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