Front Med (Lausanne) . 2023 Aug 2;10:1200592. doi: 10.3389/fmed.2023.1200592
Rui Wang # 1 2, Zheng-Ming Wang # 3, Si-Cheng Xiang 4, Zhao-Kai Jin 4, Jing-Jing Zhang 4, Ji-Cheng Zeng 4, Pei-Jian Tong 5, Shuai-Jie Lv 5
Objective: In order to examine the relationship between 25-hydroxyl vitamin D and knee osteoarthritis (KOA), a meta-analysis of 8 randomized controlled trials (RCTs) publications was hereby performed.
Methods: For the purpose of finding pertinent research, the databases of PubMed, Embase and the Cochrane Library were searched. Factors including tibial cartilage volume, joint space width (JSW), synovial fluid volume, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were correspondingly evaluated, and the results were expressed using SMD and 95% confidence intervals (CI).
Results: The present meta-analysis evaluated the effects of vitamin D supplementation in patients with knee osteoarthritis, with 3,077 patients included. The results showed that vitamin D administration had a statistically significant impact on the amount of synovial fluid, Visual Analog Scale (VAS) and tibial cartilage. The pain and function scales of the WOMAC scale presented a statistically significant difference, and there was no discernible difference between the vitamin D and placebo groups in the stiffness scale. Additionally, bone marrow lesions and alterations in the diameter of the joint space were not influenced by the administration of vitamin D, and according to a subgroup study, a daily vitamin D supplement containing more than 2,000 IU significantly slowed the development of synovial tissue.
Conclusion: Vitamin D supplementation did benefit those suffering from knee discomfort and knee dysfunction.
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27+ Vitamin D Life pages with KNEE OSTEOARTHRITIS in title
This list is automatically updated
Items found: 27
| Title | | Modified |
| Knee osteoarthritis treated by Vitamin D - many studies | | 13 Dec, 2023 |
| Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023 | | 21 Aug, 2023 |
| I needed more than Vitamin D to treat my knee osteoarthritis | | 06 Nov, 2021 |
| Knee osteoarthritis helped by Low Level Laser Therapy | | 02 Nov, 2020 |
| Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 | | 21 Oct, 2020 |
| Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 | | 10 Oct, 2018 |
| Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 | | 10 Jul, 2018 |
| Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 | | 29 Jul, 2017 |
| Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 | | 29 Jul, 2017 |
| Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 | | 29 Jul, 2017 |
| Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 | | 20 Jul, 2017 |
| Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 | | 25 Apr, 2017 |
| Knee osteoarthritis strongly associated with low Boron – 2015 | | 24 Mar, 2017 |
| Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 | | 24 Dec, 2016 |
| Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 | | 21 Dec, 2016 |
| Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 | | 06 Oct, 2016 |
| Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 | | 06 Oct, 2016 |
| Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 | | 08 Mar, 2016 |
| Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 | | 03 Oct, 2015 |
| Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT | | 08 Aug, 2015 |
| Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 | | 12 Apr, 2015 |
| Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 | | 23 Feb, 2015 |
| Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 | | 07 Oct, 2014 |
| Blacks had lower vitamin D and more quantifiable pain than whites with knee osteoarthritis – Nov 2012 | | 11 May, 2014 |
| Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 | | 10 Nov, 2012 |
| Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 | | 10 Nov, 2012 |
| Knee Osteoarthritis pain cut in half by eating sesame seed powder for 2 months - Oct 2019 | | No value for 'modification_date_major' |
Vitamin D Life – Osteoarthritis category contains
| 59 |
items total - see also Overview Osteoporosis and vitamin DOverview Osteoarthritis and Vitamin D
Knee Osteoarthritis treated by Vitamin D - meta-analysis Aug 2023
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020
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