Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study
J Steroid Biochem Mol Biol. 2021 Jul 28;105958. doi: 10.1016/j.jsbmb.2021.105958
Cédric Annweiler 1, Mélinda Beaudenon 2, Romain Simon 2, Mialy Guenet 2, Marie Otekpo 2, Thomas Célarier 3, Jennifer Gautier 2, GERIA-COVID study group
Note: This study combined all infrequent dosing into intervention data
- 50,000IU per month, or
- 80,000IU or 100,000IU or 200,000IU every 2-3 months
Note: The vitamin D levels did not rise very much for those getting this small amount of vitamin D
Note: 2-3 months dosing produces less than half the response as monthly dosing
Items in both categories Virus and Loading Dose are listed here:
- COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France – July 2021
- 600,000 IU of Vitamin D helped 26 out of 28 COVID-19 patients in ICU (Brazil and Bolivia) June 2021
- Infectious Mononucleosis (virus) treated by high dose Vitamin D (3 cases) – March 2021
- Those getting high dose vitamin D were 7 X less likely to die of COVID-19 - Dec 11, 2020
- COVID-19 Vitamin D: Overview by Dr. in Sri Lanka (Video and transcript) - Dec 8, 2020
- Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June - Sept 26, 2020
- Severe COVID-19 not fought by vitamin D when given too late - RCT Nov 18, 2020
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
- French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020
- Residents of a Nursing Home who choose monthly Vitamin D had 4X fewer COVID-19 deaths – Nov 2, 2020
- Cerebral malaria deaths prevented by loading dose of vitamin D (mice) – Sept 2018
Loading Dose of Vitamin D category has the following
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Injection category listing has
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses
The TOP articles in Loading Dose of Vitamin D are listed here:
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Vitamin D could be restored in 60 days (actually much faster) – June 2018
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Rickets cured for 3 months with 10,000 IU per kg vitamin D (600,000 IU max) – Sept 2012
Note: >70% of the RCT using Vitamin D to fight COVID-19 are using
at least 100,000 IU during the first week
Download the PDF from Vitamin D Life
Vitamin D Life suspect that there is data error.
The above table shows that those supplementing had LOWER vitamin D levels
Background: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.
Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000IU per month, or 80,000IU or 100,000IU or 200,000IU every 2-3 months), or daily supplementation with 800IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration.
Results: 76.1% (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6% (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23[95%CI:0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008).
Conclusions: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.
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| 16015 | 50K per month helped_compressed.pdf | PDF 2021 | admin 01 Aug, 2021 13:40 | 214.23 Kb | 33 |