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COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT – July 2022


Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients 2022, 14(15), 3048; https://doi.org/10.3390/nu14153048
Sophie De Niet et.all

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Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo.
The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (

  • 4 days vs. 8 days; p = 0.003).

At Day 7, a significantly lower percentage of patients were

  • still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161),

and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo.
Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.
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Note: All participants initially had <20 ng of vitamin D


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Created by admin. Last Modification: Sunday October 2, 2022 01:07:28 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
18533 COVID 25K table.jpg admin 02 Oct, 2022 146.61 Kb 195
18532 COVID 25,000.jpg admin 02 Oct, 2022 38.41 Kb 246
18531 COVID 25K_CompressPdf.pdf admin 02 Oct, 2022 217.33 Kb 162