Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study
preprints.org > life sciences > biochemistry > doi: 10.20944/preprints202104.0173.v1
Joaquim Oristrell * ORCID logo , Joan C. Oliva , Isaac Subirana , Enrique Casado , Didier Dominguez , Andrea Toloba , Patricia Aguilera , Joan Esplugues , Pilar Fafian , Maria Grau *
Calcitriol, the fully activated form of Vitamin D, is typically only available by prescription.
This study only has statistics for Yes/No, taking any amount of Calcitriol.
The charts appear to indicate death rates when COVID-19 came to the region.
It appears that there was an increased death rate of 9X for low vs high Calcitriol ( 0.18 / 0.02)
No indication of death rate for zero vs high Calcitriol
Suspect that the Calcitriol was given daily
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D, the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012 - Category Kidney and Vitamin D contains
208 items Getting Vitamin D into your body has the following chart
- Active vitamin D (calcitriol) might fight COVID-19 – Jan 5, 2021
- Kidney failure – still debating what form of vitamin D to use – April 2016
- 26 health factors increase the risk of COVID-19 – all are associated with low vitamin D CDC
- Chronic Kidney Disease is one of the factors for increased COVID-19 risk
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- Nursing home residents who happened to be taking Vitamin d were 9X less likely to die of COVID-19
- very similar to the Kidney study on this page
- Nursing home residents who happened to be taking Vitamin d were 9X less likely to die of COVID-19
Download the PDF from Vitamin D Life
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in ex-perimental models of acute lung injury. In this study we aimed to analyze the associations be-tween calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality. Associations between calcitriol supplementation and outcome variables were analyzed using multivariable Cox proportional regression. A total of 8076 patients were identified as being on calcitriol treatment. Advanced chronic kidney disease and hypoparathyroidism were the most frequent reasons for calcitriol supplementation in our population.
Title change made April 12, 2021 caused the visitor count to reset.
Calcitriol use was associated with reduced risk of SARS-CoV2 infection (HR 0.78 [CI 95% 0.64-0.94], p=0.010), reduced risk of severe COVID-19 and reduced COVID-19 mortality (HR 0.57 (CI 95% 0.41-0.80), p=0.001) in patients with advanced chronic kidney disease. In addition, an inverse association between mean daily calcitriol dose and COVID-19 severity or mortality was observed in treated patients, independently of renal function. Our findings point out that patients with advanced chronic kidney disease could benefit from calcitriol supplementation during the COVID-19 pandemic.
There have actually been1229 visitors to this page since it was originally made Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021Printer Friendly PDF this page! Follow this page for updates1160 visitors, last modified 13 Apr, 2021, This page is in the following categories (# of items in each category)Kidney208 Intervention 691 Calcitriol 52 Virus 750 Attached files
ID Name Comment Uploaded Size Downloads 15424 Mortality Calcitriol.jpg admin 12 Apr, 2021 21:18 29.60 Kb 320 15423 Cumm risk.jpg admin 12 Apr, 2021 21:17 20.17 Kb 251 15422 Calcitriol Kidney COVID-19.pdf PDF 2021 admin 12 Apr, 2021 21:17 989.41 Kb 118 See any problem with this page? Report it (FINALLY WORKS)