Table of contents
- Prevalence of Vitamin D Deficiency in Children with Fractures: Before and during the COVID-19 Outbreak
- Vitamin D Life -
12 studies in both categories Infant-Child and Falls and Fractures - Other indications of lower Vitamin D during COVID
- Some vitamin D in blood is unable to get to cells/bone due to genes (pre-existing or mutated by COVID)
Prevalence of Vitamin D Deficiency in Children with Fractures: Before and during the COVID-19 Outbreak
Int J Clin Pract. 2022 Jun 22;2022:4410032. doi: 10.1155/2022/4410032. eCollection 2022.
Yong-Suk Lee 1, Sang-Uk Lee 1, Tae Min Hong 1, Sun Young Joo 1Fracture - before and during
Vitamin D - before and during
Vitamin D vs season - before and during
Background: Although it is generally agreed that vitamin D is important for bone health, the role of vitamin D in preventing fractures in children and adolescents remains unclear. Therefore, this study aimed to investigate the prevalence of vitamin D deficiency and insufficiency in healthy Korean children with fractures. Our secondary aim was to compare serum vitamin D levels before and during the coronavirus disease 2019 (COVID-19) outbreak.Methods: We evaluated 334 patients with fractures who were surgically treated at our institution between 2018 and 2019 before the onset of COVID-19 (group I). In addition, we collected data on the serum 25(OH)D levels of 210 patients who visited our pediatric department for evaluation of short stature (group II) and the serum 25(OH)D levels of the patients with fractures during the COVID-19 pandemic period (group III). A serum 25(OH)D level of <20 ng/mL was considered deficient, between 20 and 32 ng/mL was insufficient, and ≥32 ng/mL was considered sufficient.
Results: The mean age was 8.1 ± 3.5 years in group I, 8.2 ± 3.7 years in group II, and 8.6 ± 3.5 years in group III. The prevalence of vitamin D deficiency was 53.0% in group I and 32.9% in group II. The mean serum 25(OH)D level was lower in group I than in group II (20.0 ± 7.3 ng/ml vs. 23.2 ± 6.9 ng/ml, p < 0.001). The mean serum 25(OH)D level of younger patients (<10 years) in group III was lower than that of the younger patients in the prepandemic period (21.4 ± 7.2 ng/mL vs. 19.2 ± 6.8 ng/mL, p=0.037).
Conclusions: We observed a high prevalence of vitamin D deficiency/insufficiency in children with fractures who required surgical treatment. During the COVID-19 pandemic, the serum vitamin D levels became even lower, especially in younger children.
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12 studies in both categories Infant-Child and Falls and Fractures This list is automatically updated
- Vitamin D deficiency in children: 9%, but up to 75% in children with fractures – April 2024
- Bone fractures of children not reduced if given little vitamin D, no Calcium etc. – RCT May 2023
- Low-energy fractures in children with low vitamin D - many studies
- Low energy bone fractures associated with low vitamin D – Dec 2022
- Increase in children with low vitamin D and with tibia fractures during COVID – June 2022
- Forearm fractures in children having low Vitamin D had 3.8 X higher risk of surgery – Aug 2020
- Vitamin D compliance 3X higher when children with fractures actually knew their low vitamin D level – March 2019
- Forearm fractures in children having low Vitamin D had 1.7X higher risk of surgery – March 2018
- Children with forearm fractures have lower levels of vitamin D – June 2017
- Children with fracture history have lower vitamin D levels (behind paywall) – June 2016
- Bone fractures in children requiring surgery were 55X more likely with low vitamin D – June 2015
- Bone fracture in children 1.8 X more likely if born in winter (low vitamin D) – Dec 2014
Other indications of lower Vitamin D during COVID
Some vitamin D in blood is unable to get to cells/bone due to genes (pre-existing or mutated by COVID)
- Some COVID hospitalizations are due to poor Vitamin D genes (Binding Protein in this commentary) – June 2022
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
36 studies in both categories Virus and Vitamin D Receptor This list is automatically updated
- COVID maximum downregulation of Vitamin D receptor and CYP27B1 resulted in death - Feb 2024
- COVID in hospital stopped by Vitamin D Receptor activators (curcumin, quercetin) – RCT June 2023
- Children with COVID 4X more likely to have poor Vitamin D Receptors (Note: COVID deactivates VDR) – April 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- COVID variants protect themselves by deactivating different VDR variants– March 2023
- Dengue Fever decimated by Vitamin D - many studies
- COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
- Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022
- COVID 3X more likely if a poor Receptor (cells get less Vitamin D from the blood) – July 2022
- Long-COVID is now the biggest COVID concern - many studies
- COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) - many studies
- COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021
- Different Vitamin D Receptor problems cause different COVID problems - Dec 2021
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021
- Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010
- COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021
- Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018
- COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021
- A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Quercetin and Vitamin D - Allies Against COVID-19
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
Increase in children with low vitamin D and with tibia fractures during COVID – June 2022Printer Friendly Follow this page for updates1044 visitors, last modified 14 Jul, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 18092 D season.jpg admin 13 Jul, 2022 79.88 Kb 156 18091 D before and during.jpg admin 13 Jul, 2022 29.61 Kb 138 18090 Fracture - before and during.jpg admin 13 Jul, 2022 111.21 Kb 179 18089 D, fractures and pandemic.pdf admin 13 Jul, 2022 400.49 Kb 114