- Role of FokI rs2228570 and Tru9I rs757343 Polymorphisms in the Mortality of Patients Infected with Different Variants of SARS-CoV-2
- Vitamin D Life - Vitamin D Receptor deactivated by some health problems - many studies
- Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
- Are People Getting Sick More Since the Covid Pandemic?- Bloomberg March 2024
Role of FokI rs2228570 and Tru9I rs757343 Polymorphisms in the Mortality of Patients Infected with Different Variants of SARS-CoV-2
Arch Med Res. 2023 Mar 31;S0188-4409(23)00053-X. doi: 10.1016/j.arcmed.2023.03.006
Hasan Rahman Shawi Shawi 1, Enayat Anvari 2, Abolfazl Fateh 3
Background and aim: Low vitamin D levels are associated with the severity of coronavirus disease 19 (COVID-19). Vitamin D receptor gene polymorphisms, such as Tru9I rs757343 and FokI rs2228570, have been suggested to be potential risk factors for severe COVID-19 outcomes. This study investigated how Tru9I rs757343 and FokI rs2228570 polymorphisms influenced the mortality rate of COVID-19 in relation to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.
Methods: The polymerase chain reaction-restriction fragment length polymorphism assay was used to genotype Tru9I rs757343 and FokI rs2228570 genotypes in 1,734 recovered and 1,450 deceased patients.
Results: Our results demonstrated that the high mortality rate was correlated with FokI rs2228570 TT genotype in all three variants but was much higher in the Omicron BA.5 variant than in the Alpha and Delta variants. Furthermore, in patients infected with the Delta variant, FokI rs2228570 CT genotype was more highly correlated with the mortality rate compared to other variants. Thus, a high mortality rate was correlated with the Tru9I rs757343 AA genotype in the Omicron BA.5 variant, whereas this relationship was not observed in the other two variants. The T-A haplotype was related to COVID-19 mortality in all three variants, but its effect was more pronounced in the Alpha variant. Moreover, the T-G haplotype was significantly associated with all three variants.
Conclusion: Our findings showed that the effects of Tru9I rs757343 and FokI rs2228570 polymorphisms were related to SARS-CoV-2 variants. However, further studies are still required to validate our findings.
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Vitamin D Life - Vitamin D Receptor deactivated by some health problems - many studies
Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of Vitamin D Life uses 10 of the 16 known VDR activators
Are People Getting Sick More Since the Covid Pandemic?- Bloomberg March 2024
by Kristen Brown
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Many studies have found that the virus that results in COVID protects itself by turning off the Vitamin D Receptor (as well as many other genes)
When COVID leaves the body, it fails to turn the receptor back on.
The cells in a person who has been infected by the virus (COVID and many others) get less vitamin D from the blood than they did before getting the virus.
This reduces the immune system capability ==> more sickness.