Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016

Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis.

PLoS One. 2016 Feb 19;11(2):e0149576. doi: 10.1371/journal.pone.0149576. eCollection 2016.
Han WG1, Hodemaekers HM2, Nagarajah B2, Poelen MM1, Helm K1, Janssen R2, van Els CA1.

Pertussis, caused by infection with the gram negative B. pertussis bacterium, is a serious respiratory illness that can last for months. While B. pertussis infection rates are estimated between 1-10% in the general population, notifications of symptomatic pertussis only comprise 0.01-0.1% indicating that most individuals clear B. pertussis infections without developing (severe) clinical symptoms. In this study we investigated whether genetic risk factors are involved in the development of symptomatic pertussis upon B. pertussis infection. Single-nucleotide polymorphisms (SNPs) in candidate genes, MBL2, IL17A, TNFα, VDR, and IL10 were genotyped in a unique Dutch cohort of symptomatic clinically confirmed (ex-)pertussis patients and in a Dutch population cohort. Of the seven investigated SNPs in five genes, a polymorphism in the Vitamin D receptor (VDR) gene (rs10735810) was associated with pertussis. The VDR major allele and its homozygous genotype were more present in the symptomatic pertussis patient cohort compared to the control population cohort. Interestingly, the VDR major allele correlated also with the duration of reported pertussis symptoms. Vitamin D3 (VD3) and VDR are important regulators of immune activation. Altogether, these findings suggest that polymorphisms in the VDR gene may affect immune activation and the clinical outcome of B. pertussis infection.

PMID: 26894582 PMCID: PMC4760950

 Download the PDF from Vitamin D Life

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• pertussis = whooping cough
• A poor Vitamin D Receptor restricts the amount of vitamin D which actually gets to cells (where the benefit happens)
• There is a greatly increased risk for over 30 diseases associated with poor Vitamin D Receptors

See also Vitamin D Life

Vitamin D Receptor category has the following

384 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement   Sun, Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D in the cells
13) Sulfroaphone and perhaps sulfur	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

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See also web

• Measles Is Just The Start: Whooping Cough Outbreaks — And Deaths — Are Rising, Too Forbes Feb 2015
  Whooping cough has been increasing along with 30 other diseases associated with low vitamin D in recent decades
  As vitamin D levels decrease the importance of the Vitamin D Receptor problems become apparant.

• Whooping Cough Cases Double in Indiana in One Year July 2017 NYT
  136 cases first half of 2017, 66 first half of 2016
  No mention of vitamin D nor Vitamin D Receptor,just vaccine
• Sodium Ascorbate Treatment of Whooping Cough April 2018
  Vitamin D not mentioned