Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71
Journal of Medical Virology, https://doi.org/10.1002/jmv.25349
Ya‐Ping Li Hui‐Ling Deng Li‐Hong Xu Mu‐Qi Wang Mei Li Xin Zhang Shuang‐Suo Dang
HFMD rarely fatal, but is increasing
- Hand, Foot, and Mouth disease (virus) strongly associated with low vitamin D – May 2017
This viral disease has been prevelant in Asia and increasing perhaps 10X in a decade
Apparently started in the US around 2010 - but is not tracked (No ID code?)
HFMD is associated with Low Vitamin D
The more severe the HFMD, the lower the vitamin D level
Children dying of HFMD have the lowest levels of vitamin D - Virus category listing has
382 } items along with related searches - 46 diseases were strongly associated with Vitamin D Receptor as of Oct 2018
Vitamin D Receptor category has the following
384 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )A poor VDR increases the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDRCompensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D in the cells 13) Sulfroaphone and perhaps sulfur Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR
Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case‐control study aimed to assess the association of single‐nucleotide polymorphisms (SNPs) in the gene encoding the VDR with the severity of EV71‐associated HFMD. We selected four VDR SNPs based on linkage disequilibrium and functional prediction, and we tested them using the SNPscan multiple SNP typing method for potential association with severity of EV71‐associated HFMD.We found a significant association in the case of
- rs11574129 (G vs A: odds ratio (OR), 0.3439; 95% confidence intervals (CI), 0.1778‐0.6653) and
- rs739837 (T vs G: OR, 0.5580; 95%CI, 0.3352‐0.9291).
Our results suggest that these two SNPs may influence the severity of EV71‐associated HFMD.
Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018Printer Friendly PDF this page! Follow this page for updates1636 visitors, last modified 23 Nov, 2018, This page is in the following categories (# of items in each category)