Loading...
 
Toggle Health Problems and D

Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010

Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes

Cellular and Molecular Life Sciences volume 67, pages4249–4256 (2010) DOI 10.1007/s00018-010-0441-4
Surya Pavan Yenamandra, Ulf Hellman, Bettina Kempkes, Suhas Deoram Darekar, Sabine Petermann, Tom Sculley, George Klein & Elena Kashuba

Vitamin D Life

Long-Haul COVID likely caused by Epstein-Barr virus (Vitamin D might help) - June 2021

Vitamin D Life Items in both categories VIRUS AND VDR

 Download the PDF from sci-hub via Vitamin D Life

Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.


Created by admin. Last Modification: Sunday October 17, 2021 21:43:01 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
16442 EBV actively deactivates vitus.pdf admin 17 Oct, 2021 21:21 474.97 Kb 1
See any problem with this page? Report it (FINALLY WORKS)