Association of polymorphisms in the vitamin D receptor gene with susceptibility to and severity of hand, foot, and mouth disease caused by Coxsackievirus A16
Medical Virology https://doi.org/10.1002/jmv.25603
Ya‐Ping Li Mu‐Qi Wang Hui‐Ling Deng Mei Li Xin Zhang Shuang‐Suo Dang Song Zhai
The risk of 43 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Items in both categories Virus and Vitamin D Receptor are listed here:
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Vitamin D Receptor activation should reduce ARDS associated with CVOID-19 - June 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Quercetin and Vitamin D —possible Allies Against Coronavirus - March 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
Coxsackievirus A16 (CA16) remains the most common causative agent of hand, foot, and mouth disease (HFMD), and is related to high incidence and critical complications. Vitamin D receptor (VDR) activity might affect the outcome of CA16 infection. Our case‐control research aims to evaluate the relationship between VDR polymorphisms in the gene encoding and susceptibility to and severity of HFMD due to CA16. Three SNPs of VDR gene were selected according to functional prediction and linkage disequilibrium, and were examined utilizing the SNPscan method to identify possible associations with HFMD caused by CA16.
A significant relationship was found in the HFMD cases of polymorphism rs11574129
- (GA vs. GG: odds ratio (OR) = 0.068, 95% confidence interval (CI) = 0.007‐0.693, P = 0.023;
- GA+AA vs. GG: OR = 0.322, 95%CI = 0.106‐0.984, P = 0.047),
and vitamin D levels in genotype AA were significantly higher than those in genotype GG (P < 0.05). These results suggest that VDR rs11574129 may influence genetic susceptibility to CA16‐associated HFMD.