Activity of Vitamin D Receptor Agonists Against Dengue Virus
Sci Rep. 2020 Jul 2;10(1):10835. doi: 10.1038/s41598-020-67783-z.
Janejira Jaratsittisin 1, Bin Xu 2, Wannapa Sornjai 1, Zhibing Weng 2, Atichat Kuadkitkan 1, Feng Li 2, Guo-Chun Zhou 3, Duncan R Smith 4
This study tried 7 different Vitamin D Receptors activators in the lab
Tried adding both before or after adding the Dengu virus
Adding activators 1-3 hours after gave the best results
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc
Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activators
Vitamin D fights many viral infections
- Dengue virus prevented by a small amount of Vitamin D – RCT Nov 2019
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Hill's Criteria indicates that COVID-19 will be treated by Vitamin D - Annweiler June 8 2020
- The role of vitamin D in reducing risk of COVID-19: a brief survey of the literature - June 9, 2020
- COVID-19 associated with low Vitamin D in more than 20 studies – May 21, 2020
- Quercetin and Vitamin D —possible Allies Against Coronavirus - March 2020
- Quercetin activates the Vitamin D Receptor
Many studies have found that VDR activation decreases viral infection
Probably COVID-19 virual infection can also be reduced by VDR activation
Items in both categories Virus and Vitamin D Receptor are listed here:
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Vitamin D Receptor activation should reduce ARDS associated with CVOID-19 - June 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Quercetin and Vitamin D —possible Allies Against Coronavirus - March 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
COVID-19 links
COVID-19 news
COVID-19 recently updated files
COVID-19 and Vitamin D
COVID-19 and Dark Skins
Download the PDF from Vitamin D Life
Infections with the mosquito-transmitted dengue virus (DENV) are a pressing public health problem in many parts of the world. The recently released commercial vaccine for DENV has encountered some problems, and there is still no effective drug to treat infections. Vitamin D has a well characterized role in calcium and phosphorus homeostasis, but additionally has a role in the immune response to bacterial and viral pathogens. In this study a number of fused bicyclic derivatives of 1H-pyrrolo1,2imidazol-1-one with vitamin D receptor (VDR) agonist activity were evaluated for possible anti-DENV activity. The results showed that five of the compounds were able to significantly inhibit DENV infection. The most effective compound, ZD-3, had an EC50 value of 7.47 μM and a selective index of 52.75. The compounds were only effective when used as a post-infection treatment and treatment significantly reduced levels of infection, virus output, DENV protein expression and genome copy number. These results suggest that these VDR agonists have the potential for future development as effective anti-DENV agents.