Table of contents
- Serial negative response after standard and third (Booster) dose of COVID-19 inactivated vaccine is associated with low vitamin D levels in patients with solid cancers
- There is a strong association between a poor VDR and many health problems
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Diseases associated with a poor Vitamin D Receptor
- Vitamin D Life - Vitamin D Receptor (Cancers OR Viruses) - many studies 78 studies as of Aug 2022
- Sometimes the health problem deactivates the VDR (thus protecting itself from Vitamin D)
- Vitamin D Life - Vaccination in 172 titles as of Aug 2022
Serial negative response after standard and third (Booster) dose of COVID-19 inactivated vaccine is associated with low vitamin D levels in patients with solid cancers
Front Med (Lausanne). 2022 Jul doi: 10.3389/fmed.2022.898606. eCollection 2022.
Yifei Ma 1 , Pengfei Zhu 2 , Guanqing Zhong 3 , Dao Wang 4 , Lu Cao 5 , Shenrui Bai 5 , Youlong Wang 6 , Ao Zhang 3 , Xinjia Wang 1 7
Introduction: The response is poorly understood to the third dose in patients with cancer who failed the standard dose of inactivated SARS-CoV-2 vaccines (CoronaVac). We aim to assess the immune response to the third dose and identify whether vitamin D deficiency is associated with serial serologic failure in patients with cancer.
Methods: Solid cancer patients (SCP-N) and healthy controls (HCs) who were seronegative after the standard-dose vaccines in our previous study were prospectively recruited, from October 2021 to February 2022, to receive the third dose vaccines and anti-SARS-CoV-2S antibodies were measured. SCP-N who failed the third dose (serial seronegative group, SSG) were matched by propensity scores with the historical standard-dose positive cancer patient group (robust response group, RRG). An exploratory analysis was carried out to validate the role of vitamin D on the serology response.
Results: The multi-center study recruited 97 SCP-N with 279 positive controls as RRG and 82 negative controls as HC group. The seroconversion rate after third-dose vaccination was higher in SCP-N than in HC (70.6% vs. 29.4%, p < 0.01). The matched comparison showed that patients in SSG had a significantly lower level of vitamin D and consumption rate than RRG or RRG-B (RRG with third-dose positive) (all p < 0.01). None had serious (over grade II) adverse events after the third dose.
Conclusion: Solid cancer patients with second-dose vaccine failure may have a relatively poor humoral response to the third dose of COVID-19 vaccines as compared with the seronegative HC group. The consecutively poor humoral response could be associated with poor vitamin D levels and intake. Vitamin D status and cancer-related immune compromise may jointly affect the humoral response following booster vaccination.
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There is a strong association between a poor VDR and many health problems
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
The Vitamin D Receptor is associated with many health problems
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14)Butyrate especially gut | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Diseases associated with a poor Vitamin D Receptor
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Vitamin D Life - Vitamin D Receptor (Cancers OR Viruses) - many studies 78 studies as of Aug 2022
- Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022
- Cancers and Vitamin D Receptors, including change with race – Feb 2021
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
Sometimes the health problem deactivates the VDR (thus protecting itself from Vitamin D)
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010
- Herpes (Cytomegalovirus) downregulates the vitamin D receptor by 8X – Jan 2017
- Lyme disease massively deactivates the Vitamin D Receptor - 2019
Vitamin D Life - Vaccination in 172 titles as of Aug 2022
- Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022
- COVID vaccination: 29 percent higher antibody response if more than 20 ng of vitamin D – March 2022
- COVID vaccination makes 6X more antibodies in those having good levels of both vitamin D and Iron – June 2021
- COVID, influenza, hepatitis B, measles, etc. vaccine responses vary with Vitamin D and its receptor
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