Table of contents
- The Effect of Combined Magnesium and Vitamin D Supplementation on Vitamin D Status, Systemic Inflammation and Blood Pressure: A Randomized Double-Blinded Controlled Trial
- Vitamin D Life summary
- Vitamin D Life - Magnesium and Intervention
- Vitamin D Life - Magnesium and Obesity
- Vitamin D Life - Magnesium and Vitamin D contains
- Vitamin D Life - Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
The Effect of Combined Magnesium and Vitamin D Supplementation on Vitamin D Status, Systemic Inflammation and Blood Pressure: A Randomized Double-Blinded Controlled Trial
Nutrition April 1, 2020 https://doi.org/10.1016/j.nut.2022.111674 PDF is behind a $31 paywall
May M.Cheung1Rosemary D.Dall2Patricia A.Shewokis3AsmaAltasan4Stella L.Volpe5ReneeAmori6HarpreetSingh7DeepthaSukumar3
- Improving magnesium and vitamin D status concomitantly in the Owt/Ob population may lead to greater improvements in cardiometabolic outcomes than vitamin D supplements alone.
- Participants who received MagD had a greater increase in serum 25OHD compared to participants in VitD Group.
- There were no statistically significant effects of treatment on serum PTH concentrations, markers of inflammation, and blood pressure between and within groups.
- A combined magnesium and vitamin D treatment may be more effective in raising serum 25OHD concentrations compared to vitamin D supplement alone in Owt/Ob
Objective
Poor vitamin D and Magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with heightened cardiovascular disease risk. Magnesium is a cofactor that assists in vitamin D metabolism. We aimed to determine (1) the efficacy of a combined magnesium and vitamin D regimen compared to vitamin D only on raising serum 25-hydroxyvitamin D (25OHD) concentrations, and (2) the effects of these supplements on cardiometabolic outcomes.
Methods
This was a 12-week double-blind, randomized controlled trial with three treatment arms:
- 1) magnesium + vitamin D (MagD) Group (360 mg magnesium glycinate + 1000 IU vitamin D 3 daily),
- 2) vitamin D only (VitD) Group (1000 IU vitamin D 3 daily), and
- 3) a Placebo Group.
A total of 95 overweight or obese participants were randomized into one of the three study arms. Anthropometry, dietary intake, concentrations of serum 25OHD, serum parathyroid hormone (PTH), serum inflammatory markers, and blood pressure were obtained at baseline and week 12.
Results
The MagD group experienced the greatest increase in serum 25OHD concentrations (by 6.3±8.36 ng/mL, p<0.05). There was a decrease in systolic blood pressure (by 7.5±8.26 mmHg, p<0.05) for individuals who had a baseline systolic blood pressure >132 mmHg for the MagD group. There were no statistically significant treatment effects on serum PTH concentrations and markers of inflammation.
Conclusion
A combined magnesium and vitamin D treatment may be more effective in increasing serum 25OHD concentrations compared to vitamin D supplementation alone in Owt/Ob individuals.
Vitamin D Life summary
Daily diet of the overweight/obese contained 300 mg of Magnesium,
1,000 IU of Vitamin D for 3 months got a response ot 2 ng
Note: Response to 1000 IU typically takes 6 months
Note: Small response is expected in those who are overweight or obese
Adding just 51 mg daily of Magnesium Glycinate got a Vitamin D response of 6 ng
Note: A few years ago it appeared that the maximum update of Mg was only 100 mg per meal
Note: Have seen many studies showing increased Vitamin D response, but none this big
Speculation: Magnesium might have extracted some of the vitamin D stored in the fat tissue
This could be determined by having a trial arm that only added Magnesium, with no Vitamin D
Vitamin D Life - Magnesium and Intervention
This list is automatically updated
- Short-term response to 1,000 IU of Vitamin D tripled in obese when Magnesium was added – RCT April 2022
- Weekly Vitamin D plus daily Magnesium is great (reduced depression in obese women in this case) – July 2021
- Vitamin D and Calcium do not increase bone density (also need exercise, Mg, K2, protein etc.) – RCT Aug 2019
- Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018
- Response and adverse effects of 20,000 and 30,000 IU Vitamin D weekly - Feb 2015
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022
- Off Topic: EDTA similar reduction in heart attack as Vitamin C, aspirin and Mg – RCT March 2013
Vitamin D Life - Magnesium and Obesity
This list is automatically updated
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- More Magnesium needed by obese (Mg Sulfate, women in this case) – RCT Dec 2021
- PTH failed to decrease with Vitamin D if overweight and had low Magnesium – Aug 2019
- Magnesium may help with calorie restriction, ALS, and R-loops in DNA - LEF Oct 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Obesity epidemic: a perfect storm of deficiency of vitamin D, Magnesium, Iodine, etc – May 2012
- Obesity pandemic since 1975 - is it due to Vitamin D, Magnesium, Iodine, adenovirus, or what
- Reasons for low response to vitamin D
- Weight loss and Vitamin D, Calcium, and Magnesium
- Overview Magnesium and vitamin D
Vitamin D Life - Magnesium and Vitamin D contains
- Overview Magnesium and vitamin D
- Magnesium deficiency – causes and symptoms – May 2016
- Vitamins and Metals needed by the Immune System – Jan 2020
- Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
- Magnesium etc. reduced in crops (must supplement) – 2009
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
- Magnesium is important for health but levels are low – July 2018
- Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018
- How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
Mg and Vitamin D
- Vitamin D and Magnesium need each other - many studies
- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
- 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
- Magnesium supplementation raises Vitamin D if initially less than 30 ng – RCT Dec 2018
- Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
- Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
- Vitamin D Cofactors in a nutshell
- Magnesium and Vitamin D - similar, different and synergistic
Dr. Dean
- Some Podcasts by Dr. C Dean – Magnesium, Vitamin D, Iodine, etc.
- Magnesium and the body - depletion and reduced intake - Dean Oct 2019
- Magnesium, Vitamin D, Omega-3, TSH - importance and testing - Dean and Baggerly - Oct 2019
Number of studies in both of the categories of Magnesium and:
BoneVitamin D Life - Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
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