Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient's lung cells
Sci Rep . 2021 Apr 21;11(1):8570. doi: 10.1038/s41598-021-87703-z.
Bijesh George 1 2, Revikumar Amjesh 1, Aswathy Mary Paul 1 2, T R Santhoshkumar 1, Madhavan Radhakrishna Pillai 3, Rakesh Kumar 4 5 6
Up and Down regulation (One of scores of charts in the PDF)
This preprint of this study was reviewed in Medical News Net Dec 22, 2020
- Health problems that have learned to de-regulate the Vitamin D metabolism require higher blood levels of Vitamin D
- COVID-19 affects the CYP27A1 gene, which results in less Vitamin D to be produced in the blood
- The CYP27A1 gene can be bypassed in two ways
- Topical or mucosal Vitamin D - dissolve Vitamin D powder in water or use nanoemulsion
- Semi-activated Vitamin D (Calcidiol) which was found to be very successful in one clinical trial
- Note: Calcidiol is high cost and prescription-only for humans, but is available at low cost to animal doctors
- There are 10+ ways to increase the Vitamin D Receptor activation
Genetics category listing contains the following
see also
395 articles in Vitamin D Receptor 145 articles in Vitamin D Binding Protein = GC 36 articles in CYP27B1 - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
Items in both categories Virus and Vitamin D Receptor:
- SARS-CoV-2 virus alters the activation of over 100 vitamin D related genes in the lung – April 2021
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Vitamin D Receptor activation should reduce ARDS associated with CVOID-19 - June 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Quercetin and Vitamin D —possible Allies Against Coronavirus - March 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
 Download the PDF from Vitamin D Life
Table of contents
Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient's cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein-protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-κB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here provide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection.SARS-CoV-2 virus alters the activation of over 100 vitamin D related genes in the lung – April 2021263 visitors, last modified 28 Apr, 2021, This page is in the following categories (# of items in each category)Genetics275 Vitamin D Receptor 395 Vit D Binding Protein 145 Virus 609 CYP27B1 36 Attached files
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