Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection
Nutrients 2021, 13(7), 2430; https://doi.org/10.3390/nu13072430
by Liam Townsend 1,2,*OrcID,Adam H. Dyer 3OrcID,Patrick McCluskey 4,Kate O’Brien 5,Joanne Dowds 5,Eamon Laird 3,6OrcID,Ciaran Bannan 1,2,Nollaig M. Bourke 3,Cliona Ní Cheallaigh 1,2OrcID,Declan G. Byrne 2,4OrcID andRose Anne Kenny 6,7
Long-Haul = Long-COVID = post-acute sequelae of SARS-CoV-2 infection, (PASC)
has many overlaps with previous SARS-2003, Fibromyalgia, POTS,and some infectious diseases Atlantic Sept 1, 2021
Study assumes that a 30 ng level is sufficient - it is not!
Note: Most people with >40 ng appear to not get COVID-19 or long haul
Study ignores that the vitamin D receptor can restrict vitamin D in the blood from getting to cells
__Vitamin D levels had been >50 ng
Click on chart for details
Pages in both of the categories Virus and Vitamin D Receptor:
- COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021
- A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017
- SARS-CoV-2 virus alters the activation of over 100 vitamin D related genes in the lung – April 2021
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Quercetin and Vitamin D —possible Allies Against Coronavirus - March 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activators
See "long-haul" in Vitamin D Life titles
Download the PDF from Vitamin D Life
The emergence of persistent symptoms following SARS-CoV-2 infection, known as long COVID, is providing a new challenge to healthcare systems. The cardinal features are fatigue and reduced exercise tolerance. Vitamin D is known to have pleotropic effects far beyond bone health and is associated with immune modulation and autoimmunity. We hypothesize that vitamin D levels are associated with persistent symptoms following COVID-19. Herein, we investigate the relationship between vitamin D and fatigue and reduced exercise tolerance, assessed by the Chalder Fatigue Score, six-minute walk test and modified Borg scale. Multivariable linear and logistic regression models were used to evaluate the relationships. A total of 149 patients were recruited at a median of 79 days after COVID-19 illness. The median vitamin D level was 62 nmol/L, with n = 36 (24%) having levels 30–49 nmol/L and n = 14 (9%) with levels <30 nmol/L. Fatigue was common, with n = 86 (58%) meeting the case definition. The median Borg score was 3, while the median distance covered for the walk test was 450 m. No relationship between vitamin D and the measures of ongoing ill-health assessed in the study was found following multivariable regression analysis. These results suggest that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D.