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Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020

The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

J Med Virol. 2020 Aug 8. doi: 10.1002/jmv.26409
Lutfiye Karcioglu Batur 1, Nezih Hekim 1

Vitamin D Life

Items in both categories Virus and Vitamin D Receptor are listed here:

Items in both categories Virus and Vitamin D Binding Protein are listed here:

Vitamin D Binding Protein category listing has 141 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,

Vitamin D Binding Protein has a list of health problems

Health Problem
11 XPreeclampsia
6 XFood Allergy
4 X, 5XKidney Cancer
4 XPoor Response to Oral Vitamin D
3 XEar infection
2 X MS
2 X Colorectal Cancer
2 XProstate Cancer -in those with dark skins
1.3 XInfertility

Genetics category listing contains the following

266 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by Vitamin D Life as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

 Download the PDF from sci-hub via Vitamin D Life

Since December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has given rise to emerging respiratory infections with a pandemical diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. The main goal of this study was to evaluate if there is any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID-19 and its mortality rates caused among populations of ten countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype (p < 0.05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations (p < 0.05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech and Turkey. The variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588.

 Download the Letter to Eidtor from Vitamin D Life

Created by admin. Last Modification: Thursday September 17, 2020 12:47:34 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
14318 Vitamin D binding protein in COVID-19 letter to editor.pdf PDF 2020 admin 17 Sep, 2020 12:46 98.71 Kb 20
14159 DBP and COVID-19.pdf PDF 2020 admin 10 Aug, 2020 13:26 170.30 Kb 53
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