- Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research
- VitaminDwiki - Genetics category contains
- VitaminDwiki - Some diseases reduce vitamin D getting to blood or cells
- VitaminDwiki - CYP27B1 category contains
- VitaminDwiki - Cancers might alter CYP24A1 gene
- Vitamin D Life - Vitamin D Binding Protein category listing has
180 items - Vitamin D Life - Health problems associated with poor Vitamin D Binding Protein (GC)
- Vitamin D Life - The Vitamin D Receptor is associated with many health problems
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Vitamin D Life - Vitamin D Receptor category contains
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Increased risk of diseases if poor VDR
- Diseases associated with a poor Vitamin D Receptor
- Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research
Nutrients 2022, 14(13), 2735; https://doi.org/10.3390/nu14132735
by Rasha Shraim 1,2,3ORCID,Conor MacDonnchadha 1,2ORCID,Lauren Vrbanic 1,2,Ross McManus 2,† andLina Zgaga 1,*,†- 1 Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, D24 DH74 Dublin, Ireland
- 2 Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, D08 W9RT Dublin, Ireland
- 3 The SFI Centre for Research Training in Genomics Data Sciences, National University of Ireland Galway, H91 CF50 Galway, Ireland
Vitamin D is essential for good health. Dermal vitamin D production is dependent on environmental factors such as season and latitude, and personal factors such as time spent outdoors and genetics. Varying heritability of vitamin D status by season has been reported, suggesting that gene-environment interactions (GxE) may play a key role. Thus, understanding GxE might significantly improve our understanding of determinants of vitamin D status. The objective of this review was to survey the existing methods in GxE on vitamin D studies and report on GxE effect estimates. We searched the Embase, Medline (Ovid), and Web of Science (Core Collection) databases. We included only primary research that reported on GxE effects on vitamin D status using 25-hydroxyvitamin D as a biomarker.
Sun exposure was the only environmental exposure identified in these studies. The quality assessment followed the Newcastle–Ottawa Scale for cohort studies. Seven studies were included in the final narrative synthesis. We evaluate the limitations and findings of the available GxE in vitamin D research and provide recommendations for future GxE research. The systematic review was registered on PROSPERO (CRD42021238081).Download the PDF from Vitamin D Life
VitaminDwiki - Genetics category contains
353 articles in the Genetics category see also
- Vitamin D Receptor has
548 items - Vitamin D Binding Protein = GC has
180 items - CYP27B1 has
67 items - CYP24A1 in title of 39+ items
- CYP2R1 25+ items
- Calcidiol has
49 items - Calcitriol has
64 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Glutathione improves the activation of 6 Vitamin D genes - the most known as of May 2025
- Getting Vitamin D into your blood and cells
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if the conventional Vitamin D test shows an increase)
3) DNA and VDR tests - 100 to 200 dollars $100 to $250
4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
5) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc- The founder of Vitamin D Life took action with clues #3&5
VitaminDwiki - Some diseases reduce vitamin D getting to blood or cells
Some diseases restrict vitamin D by changing gene activation,
by one or more of the following- Restrict conversion of light into vitamin D in the skin
- Restrict oral absorption in the gut
- Restrict semi-activation in the liver
- Restrict free semi-activated vitamin D from getting to the kidneys
- Restrict full activation in the kidneys
- Restrict semi and fully activation in the cells
- Restrict activated Vitamin D from entering cell mitochondria (VDR)
- Destroy the vitamin D before it gets to the cells
Some diseases restrict vitamin D without changing genes
- The disease just uses/consumes the vitamin D
- The disease upsets the gut, which reduces bioavailability of oral form
- unless a gut-friendly form is used
References
- COVID changes 100 vitamin D-related genes in the lungs
- Reasons for low response to vitamin D
- Genetics category has
353 items along with related searches - The risk of 44 diseases at least double with poor VDR as of Oct 2019
VitaminDwiki - CYP27B1 category contains
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, RicketsCYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
67 items in CYP27B1 category 353 articles in the Genetics 548 articles in Vitamin D Receptor 180 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
--=VitaminDwiki - Cancers might alter CYP24A1 gene
Vitamin D Life - Vitamin D Binding Protein category listing has
180 items Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 11+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Vitamin D Life - Health problems associated with poor Vitamin D Binding Protein (GC)
Increased
RiskHealth Problem 11 X Preeclampsia 6.5X T1D in SA Blacks 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2.8 X MS 2.5 X Severe Autism 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility Vitamin D Life - The Vitamin D Receptor is associated with many health problems
548 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells52 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 14 studies), Cardiovascular ( 23 studies), Cognition ( 17 studies), Diabetes ( 25 studies), Hypertension ( 9 studies), Infant ( 23 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 17 studies), Obesity ( 17 studies), Pregnancy ( 25 studies), Rheumatoid Arthritis ( 11 studies), TB ( 8 studies), VIRUS ( 41 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDRHow to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14) Butyrate especially gut Vitamin D Receptor 15) Berberine Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Vitamin D Life - Vitamin D Receptor category contains
548 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells52 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 14 studies), Cardiovascular ( 23 studies), Cognition ( 17 studies), Diabetes ( 25 studies), Hypertension ( 9 studies), Infant ( 23 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 17 studies), Obesity ( 17 studies), Pregnancy ( 25 studies), Rheumatoid Arthritis ( 11 studies), TB ( 8 studies), VIRUS ( 41 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDRHow to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14) Butyrate especially gut Vitamin D Receptor 15) Berberine Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk of diseases if poor VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activationDiseases associated with a poor Vitamin D Receptor
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activationVitamin D Life - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Metflormin (Kidney) Ginger, Essential oils, etc Note: The founder of Vitamin D Life uses 10 of the many VDR activators
Vitamin D genes – Review June 2022(Cached) Printer Friendly Follow this page for updates14113 visitors, last modified 05 Jan, 2024, This page is in the following categories (# of items in each category)Attached files
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- Vitamin D Binding Protein = GC has