Summary of many studies of Vitamin D and organ transplantation
More vitamin D needed especially needed if organ = liver or kidney (low vitamin d ==> poor bones)
Both regular and active vitamin D have been used
Supplementation can be oral, injection, etc
Extra Vitamin D can be before or after the surgery
Problems avoided include: infection, rejection, death
Vitamin D in organ transplantation - 2011
Osteoporos Int. 2011 Jan 5.
Stein EM, Shane E.
Department of Medicine, Columbia University Medical Center, 630 West 168th Street, PH8-864, New York, NY, 10032, USA, es2029 at columbia.edu.
Vitamin D deficiency is prevalent among patients with end-stage organ failure awaiting transplant. Low serum 25-hydroxyvitamin D (25-OHD) levels in these patients may be related to many disease-specific factors, as well as decreased sunlight exposure and limited intake of foods containing vitamin D.
Low serum 25-OHD levels are also extremely common following solid organ transplantation, both during the immediate postoperative period and in long-term graft recipients.
Demographic and lifestyle factors are important in determining D status in transplant recipients.
Worse vitamin D status is associated with poorer general health, lower albumin, and even decreased survival among these patients.
Although several studies have demonstrated that active forms of vitamin D and its analogues prevent bone loss following transplantation, the data do not show consistent benefit.
These therapies may have particular utility after renal transplantation. However, given the narrow therapeutic window with respect to hypercalcemia and hypercalciuria, and the demonstrated efficacy of bisphosphonates to prevent post-transplantation bone loss, we regard these agents as adjunctive rather than primary therapy for transplantation osteoporosis.
The effects of 1,25(OH)(2)D on the immune system, which are still being elucidated, may have potential for reducing infections and preventing allograft rejection after transplantation. PMID: 21207011
Survive heart transplant better if have more vitamin D
PDF is attached at the bottom of this page PDF was public domain in Dec 2012
-
See also at VitaminDWik
- Patients low on vitamin D stay in hospital longer after thyroid removal – Dec 2010
- Every Thyroidectomy patient should get vitamin D and Calcium – Nov 2010
- Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011
- Organ Transplant patients probably need more UV and or vitamin D April 2010
- Vitamin D Deficiency and Liver Disease – Aug 2010
- Vitamin D and biophospates are needed after organ transplant – Aug 2011
- 200 IU vitamin D per kg is not enough for some health problems (example– bone marrow stem cell) – July 2016
- Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011
- Kidney transplant patients advised to avoid the sun, then 90% have very low vitamin D levels – Sept 2012
- 4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012
- If you are getting a lung transplant you must have vitamin D - April 2012
- Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012
- Vitamin D levels low both before and after organ transplant July 2011
- Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011
- Search Vitamin D Life for "ORGAN TRANSPLANT" 66 items as of March 2017
- Vitamin D cut in half the fractures following organ transplant – meta-analysis Aug 2011 same authors
See also web
- Clinical Trials: Transplant and Vitamin D 60 listed as of Jan 2018
- Low Vitamin D Exposure is Associated with Higher Risk of Infection in Renal Transplant Recipients March 2017
43% fewer infections within 90 days if Vitamin D > 30 ng - Current evidence on vitamin D deficiency and kidney transplant: What's new? March 2017
Publisher wants $40 for the PDF DOI: 10.1007/s11154-017-9418-z
"Transplant patients with low calcidiol levels have an increased risk of
metabolic and endocrine problems,
cardiovascular disease,
type 2 diabetes mellitus,
poor graft survival,
bone disorders,
cancer, and
mortality rate."