Association Between Preoperative 25-Hydroxyvitamin D Level and Hospital-Acquired Infections Following Roux-en-Y Gastric Bypass Surgery
JAMA Surg. 2014;149(2):112-118. doi:10.1001/jamasurg.2013.3176
Sadeq A. Quraishi, MD, MHA； Edward A. Bittner, MD, PhD； Livnat Blum, BA；Mathew M. Hutter, MD, MPH； CarlosA. CamargoJr, MD, DrPH
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80 items in Optimum Vitamin D categoryExample studies
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Download the PDF from Vitamin D Life
IMPORTANCE Postoperative hospital-acquired infections (HAIs) may result from disruption of natural barrier sites. Recent studies have linked vitamin D status and barrier site integrity.
OBJECTIVE To investigate the association between preoperative vitamin D status and the risk for HAIs.
DESIGN, SETTING, AND PARTICIPANTS A retrospective analysis was performed using propensity score methods to construct a matched-pairs cohort to reduce baseline differences between patients with 25-hydroxyvitamin D (25[OH]D) levels less than 30 ng/mLvs 30 ng/mL or greater. Multivariable logistic regression analysis was then performed to examine the association between 25(OH)D levels and HAIs while adjusting for additional perioperative factors. Locally weighted scatterplot smoothing was used to depict the relationship between increasing 25(OH)D levels and the risk for HAIs. This study was conducted in a single, teaching hospital in Boston, Massachusetts, and involved 770 gastric bypass surgery patients between January 1, 2007, and December 31,2011.
EXPOSURES Preoperative 25(OH)D levels.
MAIN OUTCOMES AND MEASURES Association between preoperative 25(OH)D levels and the riskfor postoperative HAIs.
RESULTS The riskfor HAIswas3-fold greater (adjusted odds ratio, 3.05; 95% CI, 1.34-6.94) in patients with 25(OH)D levels less than 30 ng/mL vs 30 ng/mL or greater. Further adjustment for additional perioperative factors did not materially change this association. Locally weighted scatterplot smoothing analysis depicted a near inverse linear relationship between vitamin D status and the risk for HAIs for 25(OH)D levels around 30 ng/mL.
CONCLUSIONS AND RELEVANCE In our patient cohort, a significant inverse association was observed between preoperative 25(OH)D levels and the risk for HAIs. These results suggest that preoperative 25(OH)D levels may be a modifiable risk factor for postoperative nosocomial infections. Prospective studies must determine whether there is a potential benefit to preoperative optimization of vitamin D status.
Study was cited by 52 publications as of May 2021
- The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery- 2014 PDF
20 X less likely if very high vitamin D
Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014 121 visitors, last modified 08 Jun, 2021,
Printer Friendly PDF this page! Follow this page for updates This page is in the following categories (# of items in each category) Immunity 212 Trauma and surgery 294 Inflammation 142 Optimum 80 Attached files
ID Name Comment Uploaded Size Downloads 15678 Hospital Mortality.jpg admin 30 May, 2021 17:39 20.89 Kb 30 15677 The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery.pdf admin 30 May, 2021 17:39 218.06 Kb 20 15676 Infection 50 ng.jpg admin 30 May, 2021 16:54 28.17 Kb 174 15675 Gastric Bypass Surgery 2014.pdf admin 30 May, 2021 16:54 231.06 Kb 21
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Example studies
- Is 50 ng of vitamin D too high, just right, or not enough
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- French uncertain as to acceptable vitamin D levels: 11, 20, 30, 46 ng ( 80 percent less than 30 ng) - Oct 2013
- Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
- Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- More than 30 ng of vitamin D is sometimes needed (Kidney needs 50 ng) – March 2019
- Need at least 80 ng of vitamin D if have chronic kidney disease – May 2012
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
- Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
Download the PDF from Vitamin D Life
IMPORTANCE Postoperative hospital-acquired infections (HAIs) may result from disruption of natural barrier sites. Recent studies have linked vitamin D status and barrier site integrity.
OBJECTIVE To investigate the association between preoperative vitamin D status and the risk for HAIs.
DESIGN, SETTING, AND PARTICIPANTS A retrospective analysis was performed using propensity score methods to construct a matched-pairs cohort to reduce baseline differences between patients with 25-hydroxyvitamin D (25[OH]D) levels less than 30 ng/mLvs 30 ng/mL or greater. Multivariable logistic regression analysis was then performed to examine the association between 25(OH)D levels and HAIs while adjusting for additional perioperative factors. Locally weighted scatterplot smoothing was used to depict the relationship between increasing 25(OH)D levels and the risk for HAIs. This study was conducted in a single, teaching hospital in Boston, Massachusetts, and involved 770 gastric bypass surgery patients between January 1, 2007, and December 31,2011.
EXPOSURES Preoperative 25(OH)D levels.
MAIN OUTCOMES AND MEASURES Association between preoperative 25(OH)D levels and the riskfor postoperative HAIs.
RESULTS The riskfor HAIswas3-fold greater (adjusted odds ratio, 3.05; 95% CI, 1.34-6.94) in patients with 25(OH)D levels less than 30 ng/mL vs 30 ng/mL or greater. Further adjustment for additional perioperative factors did not materially change this association. Locally weighted scatterplot smoothing analysis depicted a near inverse linear relationship between vitamin D status and the risk for HAIs for 25(OH)D levels around 30 ng/mL.
CONCLUSIONS AND RELEVANCE In our patient cohort, a significant inverse association was observed between preoperative 25(OH)D levels and the risk for HAIs. These results suggest that preoperative 25(OH)D levels may be a modifiable risk factor for postoperative nosocomial infections. Prospective studies must determine whether there is a potential benefit to preoperative optimization of vitamin D status.
Study was cited by 52 publications as of May 2021
- The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery- 2014 PDF
20 X less likely if very high vitamin D
| 121 visitors, last modified 08 Jun, 2021, |
| ID | Name | Comment | Uploaded | Size | Downloads | |
|---|---|---|---|---|---|---|
| 15678 | Hospital Mortality.jpg | admin 30 May, 2021 17:39 | 20.89 Kb | 30 | ||
| 15677 | The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery.pdf | admin 30 May, 2021 17:39 | 218.06 Kb | 20 | ||
| 15676 | Infection 50 ng.jpg | admin 30 May, 2021 16:54 | 28.17 Kb | 174 | ||
| 15675 | Gastric Bypass Surgery 2014.pdf | admin 30 May, 2021 16:54 | 231.06 Kb | 21 |