- Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis
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39 studies in both categories Meta-analysis and Vitamin D Receptor Association of vitamin D receptor gene polymorphism with the risk of sepsis: A systematic review and meta-analysis
Medicine (Baltimore). 2023 Sep 22;102(38):e35130. doi: 10.1097/MD.0000000000035130.
Qian Li 1, Wen Li 1, Menglu Chen 1, Yihui Chai 1, Liancheng Guan 2, Yunzhi Chen 1Background: To investigate the association between sepsis and the vitamin D receptor (VDR) gene polymorphisms.
Methods: Databases including PubMed, Cochrane Library, EMbase, CNKI, Wanfang Data, and VIP Data were systematically searched. The association was assessed using odds ratios (ORs), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.4.
Results: We identified a total of 5 studies. The relationship between VDR gene polymorphisms (Apa I, Bsm I, Taq I, and Fok I), and incidence of sepsis was investigated. The results of this meta-analysis showed that the
- allelic contrast model (F vs f, P = .03, OR = 0.65, 95% CI = 0.44-0.95),
- dominant genetic model (FF vs Ff + ff, P = .02, OR = 0.53, 95% CI = 0.30-0.91), and
- codominance genetic model (FF vs ff, P = .03, OR = 0.39, 95% CI = 0.16-0.91)
of VDR Fok I locus increased the risk of sepsis, and the lack of association between the VDR Fok I gene polymorphism and the risk assessment of sepsis, based on the ethnic subgroup analysis, might be attributable to the small sample size. The risk of sepsis with Apa I, Bsm I, and Taq I did not appear to be correlated.
Conclusion subsections: This meta-analysis revealed that the VDR Fok I polymorphism is closely associated with the susceptibility to sepsis, and patients with sepsis have lower 25-hydroxyvitamin D levels. VDR Fok I gene mutations may change the risk of sepsis.
Download the PDF from Vitamin D LifeVitamin D Life – Sepsis is both prevented and treated by Vitamin D contains:
Vitamin D Life - The risk of 50+ diseases at least double with poor Vitamin D Receptor
Vitamin D Life - Vitamin D Receptor activation can be increased in 15 ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of Vitamin D Life uses 10 of the 15 known VDR activators
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39 studies in both categories Meta-analysis and Vitamin D Receptor This list is automatically updated
- Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis Sept 2023
- BPH increased risk if poor Vitamin D Receptor in Asians – meta-analysis April 2022
- Poor Vitamin D receptor reduced vitamin D levels -meta-analysis Jan 2022
- 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019
- Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis Dec 2019
- Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis Nov 2018
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
- Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis Sept 2023Printer Friendly Follow this page for updates669 visitors, last modified 28 Sep, 2023, This page is in the following categories (# of items in each category)