Vitamin D to Prevent Lung Injury Following Esophagectomy-A Randomized, Placebo-Controlled Trial.
Crit Care Med. 2018 Sep 14. doi: 10.1097/CCM.0000000000003405. [Epub ahead of print]
Parekh D1,2,3, Dancer RCA1,4, Scott A1, D'Souza VK1, Howells PA1, Mahida RY1, Tang JCY5, Cooper MS6, Fraser WD5, Tan L7, Gao F1,4, Martineau AR 8, Tucker O1,4, Perkins GD3,4, Thickett DR1,2.
Esophageal Cancer
- Esophageal Cancer 40 percent less likely in parts of UK with more sun (vitamin D) – Feb 2018
- 2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017
Cancer category starts with the following
- Cancer
211 items Overview Cancer and vitamin D - After Cancer Diagnosis
84 items - Bladder Cancer
25 items - Breast Cancer
223 items Overview Breast Cancer and Vitamin D - Colon Cancer
116 items Overview Cancer-Colon and vitamin D - Leukemia
16 items - Liver Cancer
14 items - Lung Cancer
49 items Overview Lung cancer and vitamin D - Lymphoma Cancer
22 items - Other Cancer
55 items - Ovarian Cancer
21 items - Pancreatic Cancer
55 items - Prostate Cancer
92 items Prostate Cancer and Vitamin D studies - Skin Cancer
110 items Overview Suntans melanoma and vitamin D - Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
15 articles - Breast Cancer and VDR
15 articles - Colon Cancer and VDR
9 articles - Prostate Cancer and VDR
6 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves by actively reducing Receptor activation
Overview Loading of vitamin D contains the following
Loading dose:153 studies at Vitamin D Life Vitamin D loading dose (stoss) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose is typically given- Loading = restore = quick replacement by 1 or more doses
- Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
- = 2.5 to 25 milligrams
- The size of the loading dose is a function of body weight - see below
- Unfortunately, some doctors persist in using Vitamin D2 instead of D3
- Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
- It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
- Loading is typically oral, but can be Injection (I.M,) and Topical
- Loading dose is ~3X faster if done topically or swished inside of the mouth
- Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
- The loading dose persists in the body for 1 - 3 months
- The loading dose should be followed up with on-going maintenance dosing
- Unfortunately, many doctors fail to follow-up with the maintenance dosing.
- About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
- it appears prudent to test with a small amount of vitamin D before giving a loading dose
- The causes of a mild allergic reaction appear to be: (in order of occurrence)
- 1) lack of magnesium - which can be easily added
- 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
- 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
- 4) allergy of the gut to Vitamin D - alternative = topical
Trauma and surgery category starts with the following
Trauma and Surgery category has278 articles see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis chemotherapy
Search Vitamin D Life for TBI OR "Traumatic Brain Injury" 798 items as of March 2020
Search Vitamin D Life for cathelecidin OR hCAP18 219 items as of March 2020
Search Vitamin D Life for ICU OR “critical care” OR “intensive care” OR “acute care”
1740 items as of May 2019
Search Vitamin D Life for transplant 794 items as of Jan 2018
OBJECTIVES:
Observational studies suggest an association between vitamin D deficiency and adverse outcomes of critical illness and identify it as a potential risk factor for the development of lung injury. To determine whether preoperative administration of oral high-dose cholecalciferol ameliorates early acute lung injury postoperatively in adults undergoing elective esophagectomy.DESIGN: A double-blind, randomized, placebo-controlled trial.
SETTING: Three large U.K. university hospitals.
PATIENTS: Seventy-nine adult patients undergoing elective esophagectomy were randomized.
INTERVENTIONS: A single oral preoperative (3-14 d) dose of 7.5 mg (300,000 IU; 15 mL) cholecalciferol or matched placebo.
MEASUREMENTS AND MAIN RESULTS:
Primary outcome was change in extravascular lung water index at the end of esophagectomy.
Secondary outcomes included- PaO2:FIO2 ratio,
- development of lung injury,
- ventilator and organ-failure free days,
- 28 and 90 day survival,
- safety of cholecalciferol supplementation,
- plasma vitamin D status (25(OH)D, 1,25(OH)2D, and vitamin D-binding protein),
- pulmonary vascular permeability index, and
- extravascular lung water index day 1 postoperatively.
An exploratory study measured biomarkers of alveolar-capillary inflammation and injury.
Forty patients were randomized to cholecalciferol and 39 to placebo. There was no significant change in extravascular lung water index at the end of the operation between treatment groups (placebo median 1.0 [interquartile range, 0.4-1.8] vs cholecalciferol median 0.4 mL/kg [interquartile range, 0.4-1.2 mL/kg]; p = 0.059).
Median pulmonary vascular permeability index values were significantly lower in the cholecalciferol treatment group (placebo 0.4 [interquartile range, 0-0.7] vs cholecalciferol 0.1 [interquartile range, -0.15 to -0.35]; p = 0.027).
Cholecalciferol treatment effectively increased 25(OH)D concentrations, but surgery resulted in a decrease in 25(OH)D concentrations at day 3 in both arms. There was no difference in clinical outcomes.CONCLUSIONS:
High-dose preoperative treatment with oral cholecalciferol was effective at increasing 25(OH)D concentrations and reduced changes in postoperative pulmonary vascular permeability index, but not extravascular lung water index.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
(No PDF as of Sept 18, 2018)
Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018Printer Friendly PDF this page! Follow this page for updates1369 visitors, last modified 18 Sep, 2018, This page is in the following categories (# of items in each category) - Breast Cancer and VDR
- After Cancer Diagnosis