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Miscarriage 1.6 X more likely if low vitamin D – meta-analysis May 2022


Vitamin D and miscarriage: a systematic review and meta-analysis

Fertility and Sterility https://doi.org/10.1016/j.fertnstert.2022.04.017
lJennifer A.TamblynM.B.Ch.B., Ph.D.abcNicole S.P.PilarskiM.Sc., M.B.B.S.cdAlexandra D.MarklandB.Med.Sci.eElla J.MarsonB.Med.Sci.eAdamDevallPh.D.dfMartinHewisonPh.D.aRachel K.MorrisM.B.Ch.B., Ph.D.cdfArriCoomarasamyMB.Ch.B., M.D.,

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Objective
To investigate whether a significant association between vitamin D status and the risk of miscarriage or recurrent miscarriage (RM) exists.

Design: Systematic review and meta-analysis.

Setting: Not applicable.

Patient(s):Women with miscarriage and RM.

Intervention(s)
We searched the Ovid MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane Central Register of Controlled Trials from database inception to May 2021. Randomized and observational studies investigating the association between maternal vitamin D status and miscarriage and/or vitamin D treatment and miscarriage were included.

Main Outcome Measure(s)
The primary outcome was miscarriage or RM, with vitamin D status used as the predictor of risk. Whether vitamin D treatment reduces the risk of miscarriage and RM was also assessed.

Result(s)
Of 902 studies identified, 10 (n = 7,663 women) were included: 4 randomized controlled trials (n = 666 women) and 6 observational studies (n = 6,997 women).

  • Women diagnosed with vitamin D deficiency (<50 nmol/L) had an increased risk of miscarriage compared with women who were vitamin D replete (>75 nmol/L) (odds ratio, 1.94; 95% confidence interval, 1.25–3.02; 4 studies; n = 3,674; I2 = 18%).
  • Combined analysis, including women who were vitamin D insufficient (50–75 nmol/L) and deficient (<50 nmol/L) compared with women who were replete (>75 nmol/L), found an association with miscarriage (odds ratio, 1.60; 95% confidence interval, 1.11–2.30; 6 studies; n = 6,338; I2 = 35%).

Although 4 randomized controlled trials assessed the effect of vitamin D treatment on miscarriage, study heterogeneity, data quality, and reporting bias precluded direct comparison and meta-analysis. The overall study quality was “low” or “very low” using the Grading of Recommendations, Assessment, Development and Evaluations approach.

Conclusion(s)
Vitamin D deficiency and insufficiency are associated with miscarriage. Whether preconception treatment of vitamin D deficiency protects against pregnancy loss in women at risk of miscarriage remains unknown.
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Vitamin D Life pages with MISCARRIAGE in title (31 as of June 2022)

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Items found: 34
Title Modified
Miscarriage and low Vitamin D – many studies 03 Apr, 2024
Miscarriage (Recurrent Spontaneous) associated with poor CYP27B1 gene - Jan 2024 01 Feb, 2024
Recurrent miscarriages decreased by increased Vitamin D levels - Jan 2024 29 Jan, 2024
Miscarriage 2.5X more likely if second-hand smoke and low vitamin D – Sept 2022 06 Sep, 2022
Miscarriage 1.6 X more likely if low vitamin D – meta-analysis May 2022 09 Jun, 2022
Recurrent Miscarriage 4X more likely if low vitamin D – meta-analysis June 2022 07 Jun, 2022
Recurrent pregnancy loss (miscarriage) risk should be reduced by vitamin D, vitamin B12 – March 2021 24 Dec, 2021
Researchers found flu vaccine increased miscarriage risk by 7X -Sept 2017 24 Dec, 2021
Recurrent miscarriage associated with low Vitamin D – Nov 2013 24 Dec, 2021
Recurrent pregnancy loss (miscarriage) is associated with low vitamin D in 6 ways – March 2021 25 Mar, 2021
Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019 26 Feb, 2021
Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020 15 Feb, 2020
Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017 12 Nov, 2019
Miscarriage 32 percent more likely if work night shift (probably low Vitamin D) – April 2019 05 Apr, 2019
Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017 05 Apr, 2019
Miscarriage 10 percent more likely for each 10 ng less vitamin D at preconception – May 2018 01 Aug, 2018
Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016 28 Jul, 2018
Second miscarriage associated with low vitamin D – review June 2018 20 Jun, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Cesarean (associated with low Vitamin D) increased asthma, obesity, miscarriage and stillbirth – meta-analysis Jan 2018 26 Jan, 2018
Early menarche, miscarriage and stillbirth are associated with heart disease (all are associated with low Vitamin D) – Jan 2018 18 Jan, 2018
Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017 20 Nov, 2017
APS (associated with miscarriage, stillbirth. preterm delivery and stroke) is 3X more likely if low vitamin D – meta-analysis Oct 2017 13 Oct, 2017
Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017 14 Sep, 2017
Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015 07 Jul, 2017
Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016 07 Jul, 2017
Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT July 2016 07 Jul, 2017
Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017 15 Jun, 2017
Infants have low levels of vitamin D – associations with phototherapy and miscarriage – Dec 2016 01 Jan, 2017
Infants have low vitamin D levels in infants – association with phototherapy and miscarriage – Dec 2016 01 Jan, 2017
Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016 07 Aug, 2016
Miscarriage 3X more often if very low vitamin D – Jan 2016 12 Jun, 2016
Miscarriage in 2nd trimester associated with low vitamin D – July 2012 07 Sep, 2015

Vitamin D Life - 54 studies in both categories Pregnancy and Meta-analysis

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Created by admin. Last Modification: Thursday June 9, 2022 02:18:41 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
17776 Miscarriage.jpg admin 07 Jun, 2022 36.27 Kb 149
17775 Vitamin D and miscarriage.pdf admin 07 Jun, 2022 965.29 Kb 320