Erratum of the study - June 2016 - charts with the following text
The new pooled analysis showed the effect of vitamin D is larger with the same direction for
- circulating 25-OHD (mean difference [MD], 70.69 vs. 66.46 nmol/L),
- preeclampsia (relative risk [RR], 0.89 vs. 0.88),
- gestational diabetes (RR, 1.08 vs. 1.05),
- low birth weight (RR, 0.84 vs. 0.72),
- preterm birth (RR, 1.30 vs. 1.26),
- birth weight (MD,108.62 vs. 107.60 g), and
- birth length (MD, 0.79 vs. 0.30 cm).
The new pooled analysis shows that the effect of vitamin D is smaller with the same direction for small for gestation age (RR, 0.69 vs. 0.78).
 Download the Erratum from Vitamin D Life
Strangely this erratum is not mentioned at the web site for the original publication
Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
Fertility and Sterility, Received: October 19, 2014; Received in revised form: February 11, 2015; Accepted: February 12, 2015; Published Online: March 24, 2015, DOI: http://dx.doi.org/10.1016/j.fertnstert.2015.02.019
Faustino R. Pérez-López, M.D., Ph.D. faustino.perez at unizar.es, Vinay Pasupuleti, M.D., Ph.D., Edward Mezones-Holguin, M.D., Vicente A. Benites-Zapata, M.D., Priyaleela Thota, M.D., Abhishek Deshpande, M.D., Ph.D., Adrian V. Hernandez, M.D., Ph.D.
Many of the RCT studied used very small doses of D3 or used D2 - so could not be expected to get high enough levels to make a difference. See BOLDED references for details
Virtually no Meta-analysis considers dose size
Vitamin D Life articles in Pregnancy AND Meta-analysis:
- Vitamin D reduces: pre-eclampia 1.6 X, postpartum dep. 3.6 X, autism 1.5X etc. - meta-analysis March 2024
- Vitamin D supplementation decreased the risk of preeclampsia by 39% – meta-analysis Feb 2024
- Yet another reason to take Vitamin D while pregnant – fight COVID - meta-analysis May 2023
- Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023
- Preeclampsia reduced by 33 percent if high vitamin D – meta-analysis Feb 2023
- Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
- Worse COVID during 3Q pregnancy if 2.5 ng lower Vitamin D – meta-analysis Sept 2022
- Miscarriage 1.6 X more likely if low vitamin D – meta-analysis May 2022
- Recurrent Miscarriage 4X more likely if low vitamin D – meta-analysis June 2022
- Pregnancy problems (LBW, PTB, SGA) associated with low vitamin D, 42nd meta-analysis – March 2022
- Low Vitamin D associated with preeclampsia - meta-analysis Feb 2022
- Low Vitamin D associated with pre-eclampsia -40th meta-analysis – Feb 2022
- Small vitamin D doses while pregnant do not decrease infant allergies – meta-analysis Feb 2022
- Anemia 1.6 X more likely during pregnancy if low Vitamin D – meta-analysis Dec 2021
- Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021
- Need at least 6,000 IU daily while breastfeeding to eliminate Vitamin D deficiency – meta-analysis Oct 2021
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020
- Multiple Sclerosis 40 percent more likely if mother had low vitamin D – meta-analysis Jan 2020
- Pregnancies helped by Vitamin D (insulin and birth weight in this case) – meta-analysis Oct 2019
- Preeclampsia 2.7 X less likely if 50,000 IU of Vitamin D every 2 weeks – meta-analysis Sept 2019
- Autism risk increased 30 percent by Cesareans (both low vitamin D) – meta-analysis Sept 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Birth size and weight increased by Vitamin D – meta-analysis Feb 2019
- Pregnancies helped by Vitamin D in many ways – 27th meta-analysis Jan 2019
- Vitamin D supplementation reduced SGA, fetal mortality, infant mortality – JAMA Meta – May 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017
- Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017
- Small for gestational age is 1.6 X more likely if mother was vitamin D deficient – meta-analysis Aug 2017
- Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017
- Fewer than half of pregnancies will get even 20 ng of vitamin D with 800 IU daily dose – meta-analysis May 2017
- Low Vitamin D results in adverse pregnancy and birth outcomes – Wagner meta-analysis March 2017
- Bacterial vaginosis in pregnancy increased prematurity risk by 60 percent - meta-analysis 1999
- Preterm birth rate reduced by 43 percent with adequate Vitamin D supplementation – meta-analysis Feb 2017
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- Vitamin D helps during pregnancy – meta-analysis Feb 2016
- Preterm birth 30 percent more likely if low vitamin D – meta-analysis May 2016
- Preterm birth extended by 2 weeks with Omega-3 – Meta-analysis Nov 2015
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Birth weight and length increased with high levels of vitamin D – meta-analysis March 2015
- Pregnancy and Vitamin D – meta-analysis April 2015
- More vitamin D needed during pregnancy – meta-analysis Oct 2014
- Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014
- Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013
- 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013
- 2X more likely to have preeclampsia if less than 20 ng of vitamin D – Meta-analysis Jan 2013
- Multiple Sclerosis 23 percent more likely if born in April vs. Oct – meta-analysis Nov 2012
Web
- NutraIngredients April 2015 description of the study - with a nice summary chart
Objective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables.
Design: Systematic review and meta-analysis of randomized controlled trials (RCTs).
Setting; Not applicable.
Patient(s): Pregnant women and neonates.
Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation ± calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy.
Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs).
Result(s): Thirteen RCTs (n = 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7).
Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference:
- 107.6 g (95% CI 59.9–155.3 g) and
- 0.3 cm (95% CI 0.10–0.41 cm), respectively.
Incidence of
- preeclampsia,
- GDM,
- SGA,
- low birth weight,
- preterm birth, and
- cesarean section
were not influenced by vitamin D supplementation.
Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous.
Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion.
 Download the PDF from Vitamin D Life
References
Note: the Authors of the RCT used by the meta-analysis are bolded by Vitamin D Life, along with details
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