Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
Journal of Endocrinological Investigation 09 August 2020, https://doi.org/10.1007/s40618-020-01370-x
G. E. Carpagnano, V. Di Lecce, V. N. Quaranta, A. Zito, E. Buonamico, E. Capozza, A. Palumbo, G. Di Gioia, V. N. Valerio & O. Resta
Items in both categories Breathing and Virus are listed here:
- Superspreaders appears to have viscous lung fluids – Oct 2020
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Acute viral respiratory infections reduced by Vitamin D - overview of 20 reviews - Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Respiratory viral infection (RSV) and low vitamin D – July 2020
- Zinc, respiratory tract infections and COVID-19 – July 2020
- Vitamin D reduces viral respiratory infections – editorial April 18, 2020
- Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019
- Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin
- Respiratory Virus risk reduced 35 percent by Vitamin D (14,000 IU weekly) – RCT Oct 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Colds and flu prevented and treated by Vitamin D - many studies
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
- Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017
- Acute respiratory infection worsened by too infrequent vitamin D supplementation – RCT June 2015
- Acute respiratory distress – 100 percent of patients were vitamin D deficient– April 2015
- Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014
- Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012
- Vitamin D reduces sepsis 16 studies as of Aug 2020, Often ARDS ==> Sepsis
Breathing category starts with the following
- Search Vitamin D Life for Pneumonia 1,360 items as of July 2019
- Search Vitamin D Life for phrase "COMMUNITY PNEUMONIA" 99 items - Jan 2020
- Search Vitamin D Life for BRONCHITIS 272 items as of July 2019
- Search Vitamin D Life for ASTHMA in title 142 items - Nov 2019
- COPD Overview
- Search Vitamin D Life for Wheeze 1480 items as of July 2020
- Cystic Fibrosis category listing has
41 items along with related searches - Air Pollution reduces Vitamin D
- Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
- Smoking reduces vitamin D
Supplementing with Vitamin D will improve the health of smokers and might decease craving- Overviews at Vitamin D Life:
Allergy Lung Cancer TB Asthma Influenza Colds and flu Pneumonia Respiratory infectionsThe results in this study could be due to
- ARDS ==> low vitamin D ==> Death
- Low Vitamin D ==> COVID-19 ==> ARDS ==> Death
Note only at precisely 10 days was the Risk factor 10X
If was generally <2XNote: This study chose to exclude those with the worst COVID-19 conditions = intubation
The worst of the potential "severely deficient" aren't included in the % and outcomes.
These excluded patients might be the ones with the worst inflammatory reaction (cytokine storm).Download the PDF from Vitamin D Life
Purpose
Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis.Methods
In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020.Results
Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019).Conclusions
High prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020Printer Friendly PDF this page! Follow this page for updates410 visitors, last modified 12 Aug, 2020, This page is in the following categories (# of items in each category)Breathing382 Virus 379 Attached files
ID Name Comment Uploaded Size Downloads 14161 Survival 10 ng.jpg admin 10 Aug, 2020 17:28 30.77 Kb 9123 14160 Vitamin D defciency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19.pdf PDF 2020 admin 10 Aug, 2020 17:27 643.01 Kb 84 See any problem with this page? Report it (FINALLY WORKS) - Air Pollution reduces Vitamin D