Prediabetes both prevented and treated by monthly Vitamin D, etc.

Vitamin D Life

Diabetes and Diet

• Half of Diabetics cured in 16 days by eating a plant-based diet – Dr. Greger Sept 2019

Prediabetes and progression to Diabetes

• Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016
• Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
• Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
• Normalizing vitamin D levels reduced prediabetic measure by 18 percent – RCT Oct 2012
• Prediabetics 60 percent less likely to become diabetic if given some vitamin D – Jan 2014
• Prediabetes corrected in 3 months by 1,000 IU of vitamin D as pill or in yogurt – RCT Jan 2018
• Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019

Vitamin D might also prevent becoming prediabetic

• 27 percent less likely to develop diabetes if prediabetic and have adequate vitamin D – Mar 2012
• Fewer mice became prediabetic when given Vitamin D, even when on high fat, high sugar diet – March 2017

Zinc and Magnesium also reduce progression

• Zinc cut in half the rate of prediabetes progressing to diabetes (20 mg) – RCT Oct 2017
• Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
• Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
  • Note: Both Magnesium and Zinc increase activation of Vitamin D Receptor, thus providing more vitamin D to tissues

Vitamin D treats Diabetes

• Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
• Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
• Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
• Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
• Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
  • Standard vitamin D (not gut-friendly) is not as bioavailable for many Diabetics
• Diabetes 50X less likely if 30 ng of Vitamin D and intense exercise – April 2018
• Overview Diabetes and vitamin D
• All items in Diabetes and Vitamin D 454 items

Items in both categories Diabetes and non-daily intervention are listed here:

Progression to diabetes 5X less with Vitamin D – RCT Dec 2018

Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes? A double-blind randomized clinical trial.
Diabetes Res Clin Pract. 2019 Feb;148:1-9. doi: 10.1016/j.diabres.2018.12.008
Niroomand M1, Fotouhi A2, Irannejad N3, Hosseinpanah F4.

AIMS: The aim of this study is to evaluate the effect of high-dose vitamin D on insulin sensitivity and the risk of progression to diabetes.

METHODS:
In this double-blind, placebo-controlled randomized clinical trial adults with pre-diabetes and vitamin D deficiency were randomly assigned to either vitamin D3 or placebo. Fasting plasma glucose (FPG), 2-h oral glucose tolerance test plasma glucose (OGTT PG), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and the rate of progression of glucose tolerance was compared.

RESULTS:
A total of 162 patients were randomized, from which 83 finished the 6-month follow-up (44 in intervention group and 39 in control group). In 6 months, serum 25-hydroxyvitamin D levels were significantly higher in the intervention group (36 ng/ml vs 16 ng/ml, P value < 0.001). There was no significant difference between FPG or 2H-OGTT PG in two groups. HOMA-IR score was significantly lower in the vitamin D group (2.6 vs. 3.1; P value = 0.04). The rate of progression toward diabetes was significantly lower in the intervention group (28% vs. 3%; P value = 0.002).

CONCLUSIONS: In patients with pre-diabetes and hypovitaminosis D, high dose vitamin D improves insulin sensitivity and decreases risk of progression toward diabetes.