Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: A double-blind placebo-controlled randomized trial
Diabetes & Metabolism. doi:10.1016/j.diabet.2015.03.010, Available online 27 April 2015
F. Guerrero-Romero, L.E. Simental-Mendía, G. Hernández-Ronquillo, M. Rodriguez-Morán rodriguez.moran.martha at gmail.com
Patients had, like most people, low levels of Magnesium
382 mg of Magnesium element per day in the form of Magnesium Chloride for 4 months
| Magnesium Chloride | Placebo | Units | |
| follow-up fasting | 87 | 98 | mg/dL |
| post-load glucose | 125 | 137 | mg/dL |
| HOMA-IR indices | 2.9 | 4.1 | |
| Triglycerides | 166 | 227 | |
| Serum magnesium | 2.0 | 1.6 | mg/dL |
Note: serum Magnesium tests cost > $100
Magnesium deficiency is exceeded only by Vitamin D deficiency globally
There are scores of reasons to restore Magnesium levels to where they were 50 years ago
See also Vitamin D Life
- All-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015
- If at high risk of vitamin D deficiency, get a higher response if take more Magnesium – Sept 2013
thus MgCl could have just increased Vtiamin D levels - where were not measured by study on this page - Magnesium and Vitamin D very synergistic – Aug 2013
thus MgCl could have just increased Vtiamin D levels - which were not measured by study on this page - Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Drugs Deplete Magnesium
Pages listed in BOTH the categories Diabetes and Magnesium
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010
PDF is available at deepdyve.com
Aim
This study evaluated the efficacy of oral magnesium supplementation in the reduction of plasma glucose levels in adults with prediabetes and hypomagnesaemia.
Methods
A total of 116 men and non-pregnant women, aged 30 to 65 years with hypomagnesaemia and newly diagnosed with prediabetes, were enrolled into a randomized double-blind placebo-controlled trial to receive either 30 mL of MgCl2 5% solution (equivalent to 382 mg of magnesium) or an inert placebo solution once daily for four months. The primary trial endpoint was the efficacy of magnesium supplementation in reducing plasma glucose levels.
Results
At baseline, there were no significant statistical differences in terms of anthropometric and biochemical variables between individuals in the supplement and placebo groups. At the end of follow-up fasting (86.9 ± 7.9 and 98.3 ± 4.6 mg/dL, respectively; P = 0.004) and post-load glucose (124.7 ± 33.4 and 136.7 ± 23.9 mg/dL, respectively; P = 0.03) levels, HOMA-IR indices (2.85 ± 1.0 and 4.1 ± 2.7, respectively; P = 0.04) and triglycerides (166.4 ± 90.6 and 227.0 ± 89.7, respectively; P = 0.009) were significantly decreased, whereas HDL cholesterol (45.6 ± 10.9 and 46.8 ± 9.2 mg/dL, respectively; P = 0.04) and serum magnesium (1.96 ± 0.27 and 1.60 ± 0.26 mg/dL, respectively; P = 0.005) levels were significantly increased in those taking MgCl2 compared with the controls. A total of 34 (29.4%) people improved their glucose status (50.8% and 7.0% in the magnesium and placebo groups, respectively; P < 0.0005).
Conclusion
Our results show that magnesium supplementation reduces plasma glucose levels, and improves the glycaemic status of adults with prediabetes and hypomagnesaemia.