Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials
European Journal of Clinical Nutrition advance online publication, 17 August 2016; doi:10.1038/ejcn.2016.154
N Veronese1, SF Watutantrige, C Luchini3,4 , M Solmi5,6, G Sartore, G Sergi1, E Manzato, 1', M Barbagallo, S Maggi10 and B Stubbs11
The items in both categories Diabetes and Magnesium are:
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010
Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies;other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (n = 334), Mg treatment (n = 336) reduced fasting plasma glucose (studies = 9;SMD = - 0.40;95% CI: - 0.80 to -0.00; /2 = 77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226;placebo = 227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies;SMD = - 0.35; 95% CI: - 0.62 to - 0.07;/2 = 0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance;five studies;SMD = - 0.57;95% CI: -1.17 to 0.03;/2 = 88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes.
Clipped from PDF
- "Magnesium (Mg) is . . involved in over 300 enzymatic reactions.”
- “In humans, a large meta-analysis including over than 500 000 participants, found a significant decrease of the incidence of diabetes associated with higher Mg intake”
- “Mg supplementation is well tolerated and without significant adverse effects. Given our findings, Mg supplementation is attracting interest in the treatment of diabetes and as prevention for diabetes in those at higher risk.”
- “Observational studies have demonstrated that people with diabetes appear to have lower Mg levels than healthy counterparts,
- “Previous data from observational studies have demonstrated that people without diabetes who have higher intakes of Mg are at reduced risk of diabetes.9 “
- “Our data confirm that oral Mg supplementation can improve some outcomes in this population and overcomes limitations associated with observational data.”