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Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018

Vitamin D Deficiency and Vitamin D Receptor Variants in Mothers and Their Neonates Are Risk Factors for Neonatal Sepsis.

Steroids. 2018 Mar 9. pii: S0039-128X(18)30054-0. doi: 10.1016/j.steroids.2018.03.003.
Tayel SI1, Soliman SE2, Elsayed HM3.
1 Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt. drsafaa_tayel at yahoo.com.
2 Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt.
3 Pediatric Medicine Departments, Faculty of Medicine, Menoufia University, Egypt.

Vitamin D Life

Vitamin D reduces sepsis starts with

Summary of Sepsis and Vitamin D

  • Sepsis more likely in those with poor immune systems
    Infants, elderly, sick, those with low vitamin D
  • Severe Sepsis has been associated with low vitamin D in many studies
  • Vitamin D treats Sepsis (RCT- 2015, below)
      Reduced: ICU by 8 days, Hospital stay by 7 days, and readmission rate to 0%
  • Many studies have found that a high level of Vitamin D also prevents Sepsis

Vitamin D Life recommendations for Vitamin D treatment of Sepsis in ICU

  1. Fortify the immune system as fast as possible ( Vitamin D Loading dose = Stoss dose = Bolus dose )
    Vitamin D levels can be raised very quickly
    However, Injection into muscle may provide better response than a tube down the throat
  2. Speedup the restoration of Vitamin D with sublingual or topical vitamin D
  3. Follow loading dose with maintenance doses of vitamin D - probably 50,000 IU weekly
    Note: Many studies incorrectly used no maintenance dosing, just loading dose
  4. Consider reducing Sepsis even more by adding:   Omega-3    Magnesium    Glutamine

Items in both categories Infant-child and Vitamin D Receptor are listed here:

Vitamin D Receptor category has the following

384 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphone and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

If poor Vitamin D Receptor

Health Problem
50Lyme Disease
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14Hand, Foot, and Mouth disease
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer 16.9 X another study
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

increasing prevalence of neonatal sepsis in recent years catch attention to early prevention and management. Vitamin D receptor (VDR) polymorphism can modulate VDR expression level that greatly influences immunity and susceptibility to microbial infections. We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis.

This work carried on 160 subjects classified into 80 cases (40 mothers and their 40 septic neonates) and 80 healthy controls (40 volunteer mothers and their 40 healthy neonates). Genotyping of VDR polymorphisms were assayed by real- time PCR and serum 25-hydroxyvitamin D level and hs-CRP were measured by ELISA.

Vitamin D deficiency was observed in mothers of cases compared with healthy ones (p=<0.001) and in septic neonates versus healthy ones (p=<0.001).
Septic neonates had much higher VDR FokI TT genotype (p=0.014) and T allele (p=0.003) versus healthy ones.

  • TT genotype and T allele could increase the risk of sepsis with OR 95% CI [4.804 (1.4-16.4)] and 2.786 (1.4-5.7) respectively

while VDR TaqI showed no association with sepsis. There was a strong LD between FokI and TaqI in sepsis cases. In sepsis, T/T genotype at FokI had significantly lower vitamin D (p=<0.001).

CONCLUSION: Vitamin D deficiency in mothers/neonates is a risk factor for neonatal sepsis. VDR FokI T allele had lower 25-hydroxyvitamin D level that may predispose to sepsis hazards.

PMID: 29530503 DOI: 10.1016/j.steroids.2018.03.003

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