The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility
Review Endocr Connect, 2020 Dec 1;EC-20-0484.R1. doi: 10.1530/EC-20-0484
Cecília Cristelo 1, Alexandra Machado 2, Bruno Sarmento 3, Francisco Miguel Gama 4
Items in categories Infant-Child & Diabetes & Meta-analysis:
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
463 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 50 ; Meta-analysis 30 ; Obesity 26 ; Pregnancy 39 ; T1 (child) 36 ; Omega-3 10 ; Vitamin D Receptor 20 ; Genetics 11 ; Magnesium 19 Click here to see details Diabetic Epidemic
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
162 pages in Vitamin D Life have cathelicidin as of Dec 2020Autoimmune category starts with
167 items in Autoimmune category - Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Muscular Dystrophy Lupus Psoriasis
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
Items in both categories Autoimmune and Diabetes are listed here:- Resveratrol improves health (Vitamin D receptor, etc.)
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- One autoimmune disease lowers vitamin D, a second AI disease does not lower it further – Jan 2015
- ALL autoimmune peripheral neuropathy patients had low vitamin D levels – Oct 2014
- Vitamin D protects against many types of health problems – review May 2013
- Review of Autoimmune diseases, solar radiation and vitamin D – Schwalfenberg 2012
See also web
- Chapter thirteen - Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis - 2011 https://doi.org/10.1016/B978-0-12-386960-9.00013-7
- Effect of cholecalciferol supplementation on vitamin D status and cathelicidin levels in sepsis: A randomized, placebo-controlled trial - Sept 2015 FREE PDF
- Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective? - Sept 2020 FREE PDF
Download the PDF from Vitamin D Life
Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and β cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.
Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020Printer Friendly PDF this page! Follow this page for updates141 visitors, last modified 03 Dec, 2020, This page is in the following categories (# of items in each category)
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.