More than 30 ng of vitamin D is needed for many diseases - Feb 2022

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A Narrative Review of the Evidence for Variations in Serum 25-Hydroxyvitamin D Concentration Thresholds for Optimal Health

Nutrients 2022, 14,639. https:// doi.org/10.3390/nu14030639
William B. Grant h* , Fatme Al Anouti 2 , Barbara J. Boucher 3©, Erding Dursun 4©, Duygu Gezen-Ak 4©, Edward B. Jude 5,6,7 , Tatiana Karonova 8 and Pawel Pludowski 9

Vitamin D3 has many important health benefits. Unfortunately, these benefits are not widely known among health care personnel and the general public. As a result, most of the world's population has serum 25-hydroxyvitamin D (25(OH)D) concentrations far below optimal values. This narrative review examines the evidence for the major causes of death including cardiovascular disease, hypertension, cancer, type 2 diabetes mellitus, and COVID-19 with regard to sub-optimal 25(OH)D concentrations. Evidence for the beneficial effects comes from a variety of approaches including ecological and observational studies, studies of mechanisms, and Mendelian randomization studies. Although randomized controlled trials (RCTs) are generally considered the strongest form of evidence for pharmaceutical drugs, the study designs and the conduct of RCTs performed for vitamin D have mostly been flawed for the following reasons: they have been based on vitamin D dose rather than on baseline and achieved 25(OH)D concentrations; they have involved participants with 25(OH)D concentrations above the population mean; they have given low vitamin D doses; and they have permitted other sources of vitamin D. Thus, the strongest evidence generally comes from the other types of studies. The general finding is that optimal 25(OH)D concentrations to support health and wellbeing are above 30 ng/mL (75 nmol/L) for cardiovascular disease and all-cause mortality rate, whereas the thresholds for several other outcomes appear to range up to 40 or 50 ng/mL. The most efficient way to achieve these concentrations is through vitamin D supplementation. Although additional studies are warranted, raising serum 25(OH)D concentrations to optimal concentrations will result in a significant reduction in preventable illness and death.
 Download the PDF from Vitamin D Life

Minimal levels needed

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Vitamin D Life - Vitamin D needed to TREAT Health problems

Vitamin D	Treats
150 ng	Multiple Sclerosis *
80 ng	Cluster Headache *
70 ng	Sleep *
60 ng	Preeclampsia RCT
50 ng	COVID-19 Fertility Psoriasis Infections Review Infection after surgery
40 ng	Depression ACL recovery
30 ng	Rickets

* Evolution of experiments with patients, often also need co-factors
See: Is 50 ng of vitamin D too high, just right, or not enough

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Vitamin D Life - Optimum category starts

93 items in Optimum Vitamin D category

Example pages

• Is 50 ng of vitamin D too high, just right, or not enough
• Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
• French uncertain as to acceptable vitamin D levels: 11, 20, 30, 46 ng ( 80 percent less than 30 ng) - Oct 2013
• Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
• Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
• Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
• Interview of doctor who got patients to 80 ng of vitamin D (with transcript) - Jan 3, 2022
• Need at least 80 ng of vitamin D if have chronic kidney disease – May 2012
• Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
• Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
• Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
• Hypothesis by Vitamin D Life – Vitamin D levels are no longer limited by evolution
• Vitamin D Life pages with HIGH-DOSE in title 57 as of Feb 2022

An increasing number of PubMed articles about "Optimum Vitamin D"

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GrassrootsHealth chart shows how much more might actually be needed

GRH BlogPost