Table of contents
- The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Meta-analysis of Gut and Vitamin D
- All items in categories Intervention AND Gut
- Gut and Vitamin D Receptor
- Vitamin D Life - Overview Gut and vitamin D contains
- Vitamin D Life - Overview Gut and vitamin D - gut-friendly forms of Vitamin D
The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients 2022 Jun 24;14(13):2618. doi: 10.3390/nu14132618.
Mohamed Abuelazm 1, Shoaib Muhammad 2, Mohamed Gamal 1, Fatma Labieb 3, Mostafa Atef Amin 4, Basel Abdelazeem 5 6, James Robert Brašić 7
Irritable bowel syndrome (IBS), a gastrointestinal disorder affecting 7-12% of the population, is characterized by abdominal pain, bloating, and alternating bowel patterns. Data on risk and protective influences have yielded conflicting evidence on the effects of alternative interventions, such as vitamin D. This review focuses on the effects of vitamin D on IBS. A systematic review and meta-analysis considered all articles published until 4 April 2022. The search for randomized controlled trials assessing vitamin D efficacy in IBS with outcomes, primary (Irritable Bowel Severity Scoring System (IBS-SSS)) and secondary (IBS quality of life (IBS-QoL) and serum level of calcifediol OH)D, was performed on six databases, Google Scholar, Web of Science, SCOPUS, EMBASE, PubMed (MEDLINE), and Cochrane Central Register of Controlled Trials. We included six trials with 616 patients. The pooled analysis found no difference between vitamin D and placebo in improving IBS-SSS (MD: -45.82 with 95% CI [-93.62, 1.98], p = 0.06). However, the pooled analysis favored vitamin D over placebo in improving the IBS-Qol (MD: 6.19 with 95% CI [0.35, 12.03], p = 0.04) and serum 25(OH)D (MD: 25.2 with 95% CI [18.41, 31.98], p = 0.00001). Therefore, further clinical trials are required to reach clinically applicable and generalizable findings.
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Meta-analysis of Gut and Vitamin D
- IBS - Vitamin D was the only micronutrient under DRV - meta-analysis Oct 2023
- IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023
- IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022
- IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022
- Inflammatory Bowel Disease 1.5 X more likely if low vitamin D – meta-analysis Dec 2019
- Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019
- Inflammatory bowel diseases are associated with Vitamin D etc. – meta-meta-analysis - April 2019
- IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018
- Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015
- Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015
All items in categories Intervention AND Gut
- IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021
- Diverticular disease:12X reduction if low Vitamin D and given 100,000 IU monthly – RCT Aug 2020
- Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019
- Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Vitamin D changed microbiota in gut and airway, might reduce cystic fibrosis – RCT Nov 2017
- Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017
- Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016
- IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016
- IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015
- Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015
- Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015
- Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013
- Crohn’s helped by 5000 IU vitamin D – April 2013
Gut and Vitamin D Receptor
- Crohn's and Vitamin D - many studies
- A healthy gut needs Vitamin D and a good vitamin D receptor – Sept 2022
- 14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement)
- Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020
- Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Vitamin D Receptor, the gut, the immune system, and the Middle East – May 2019
- Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017
- Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016
- Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
Vitamin D Life - Overview Gut and vitamin D contains
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019) - All items in category gut and vitamin D
203 items Vitamin D Life - Overview Gut and vitamin D - gut-friendly forms of Vitamin D
Gut-friendly, Sublingual, injection, topical, UV, sunshineGetting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gutBio Form Speed Duration 10 Injection ($$$)
or Calcidiol or CalcitriolD - Slow
C -FastLong 10 Sun/UVB Slow Long 10 Topical
(skin patch/cream, vagina)Slow
Fast nanoNormal 9 Nanoemulsion -mucosal
perhaps activates VDRFast Normal 9? Inhaled (future) Fast Normal 8 Bio-D-Mulsion Forte Normal Normal 6 Water soluble (Bio-Tech) Normal Normal 4 Sublingual/spray
(some goes into gut)Fast Normal 3 Coconut oil based Slow Normal 2 Food (salmon etc.) Slow Normal 2 Olive oil based (majority) Slow Normal 10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 monthsIBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022Printer Friendly Follow this page for updates1160 visitors, last modified 09 Jul, 2022, This page is in the following categories (# of items in each category)Attached files
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