Nanoemulsion Vitamin D is faster and better - many studies

Bought and tested several nanoemulsions

Note: The following studies compare oral nano vs oil-based vitamin D
I do not recall a study of topical, sublingual or buccal Vitamin D
   that skips the stomach, intestine, liver, and kidneys

Nanoemulsion vitamin D 40% more bio-available than fat-soluble - RCT Jan 2023

An open-label, randomized, crossover study to evaluate the bioavailability of nanoemulsion versus conventional fat-soluble formulation of cholecalciferol in healthy participants
Journal of Orthopaedics Volume 35, January 2023, Pages 64-68 https://doi.org/10.1016/j.jor.2022.10.017
Raman Kumar Marwaha a, Manish Verma b 1, Ajit Walekar c, Rakesh Sonawane b 2, Chirag Trivedi c

Background
Nanoemulsion preparations of cholecalciferol available in the market claim to have better bioavailability than the conventional fat-soluble cholecalciferol. However, limited data are available in humans for such preparations. We, therefore, compared the relative bioavailability of two formulations of 60,000 IU cholecalciferol (nanoemulsion oral solution, water-miscible vitamin D3 [test] vs soft gelatin capsules [reference]) in healthy adult participants.

Methods
In this randomized, open-label, two-sequence, single-dose, two-way crossover study (CTRI/2018/05/013839), Indian participants aged 18–45 years received single dose of nanoemulsion and capsule formulations, under fasting conditions. Blood samples collected over 120 h were assessed to determine cholecalciferol concentrations. Pharmacokinetic parameters (area under the concentration-time curve up to 120 h [AUC0–120h], maximum observed drug concentration [Cmax], time to reach maximum drug concentration [Tmax], terminal half-life [T½el], and terminal elimination rate constant Kel) were estimated using baseline corrected data and analyzed using analysis of variance.

Results
Among the 24 eligible participants, the relative bioavailability of nanoemulsion was significantly higher than the capsules by 36% (p = 0.0001) based on AUC0–120h. Similarly, Cmax of the nanoemulsion was significantly higher by 43% (p = 0.0001) than that of the capsules. The intra-participant variability for AUC0–120h and Cmax were 23.22% and 26.51%, respectively. The Tmax, T½el, and Kel were comparable for both the formulations. No adverse effects were noted with either of the two formulations.

Conclusions
Nanoemulsion oral solution of cholecalciferol showed a greater bioavailability compared with soft gelatin capsules, under fasting conditions, in healthy human participants.
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Nanoemuslion 36% more bioavailable than fat soluble forms (single 60,000 IU dose) - Dec 2019

Bioavailability of nanoemulsion formulations vs conventional fat soluble preparations of cholecalciferol (D3) – An overview
J. of Clinical Orthopaedics & Trauma Nov–Dec 2019, pg 1094-1096 https://doi.org/10.1016/j.jcot.2019.07.014
Raman Kumar Marwaha a, Aashima Dabas b

Vitamin D deficiency is recognized as a pandemic affecting all ages and strata of population. The endogenous cutaneous synthesis of vitamin D is insufficient to maintain normal body requirement which necessitates the need for vitamin D supplementation or food-fortification. Conventional fat-soluble preparations of vitamin D have been traditionally used for prevention and therapeutic purposes. Recent advances in technology have enabled delivery of vitamin D through nanoemulsion formulations which ensure higher absorption and drug delivery. The following review briefly discusses the issues of bioavailability of nanoemulsion preparation of vitamin D vis-a-vis conventional fat soluble preparations.
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"...a single oral dose of 60,000 IU in healthy participants. The results showed that relative bioavailability in terms of serum levels of cholecalciferol following supplementation with nano preparation of vitamin D3 was significantly higher than fat-soluble D3 by 36%(P ¼ 0.001) based on AUC 0-120. "
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The nanoemulsions are considered superior to conventional vitamin D preparations for the following reasons:

• a) It has greater therapeutic role in patients with malabsorption syndromes due to
  • Inflammatory bowel disease,
  • Celiac disease,
  • Short bowel syndrome,
  • Hepatobiliary disorders,
  • Pancreatic insufficiency and
  • Bariatric surgery who suffer from a deficiency of essential fatty acids and fat-soluble vitamins including vitamin D,
• b) Better compliance as it can be taken directly or with water/juice etc.
• c) Vitamin D nanoemulsions may also have also greater hepato-protective effect against high-fat diet-induced liver injury as observed in rats compared to conventional oral vitamin D preparations.

Current Update on Nanoemulsion A Review - Jan 2021

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CoVID19 VitD and Nanotechnology Review EJBPS ; Jan 2020 BioTech

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Nanoemulsions for health, food, and cosmetics

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Advances in edible nanoemulsions - Digestion, bioavailability, and potential toxicity

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Nanoemulsions SciHub 2020

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Nanoemulsions - The rising star of antiviral therapeutics

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Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods

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19+ Vitamin D Life pages with NANOEMULSION or EMULSION etc. in the title

This list is automatically updated

See also in Vitamin D Life

• Inhaled Vitamin D diluted nanoemulsion
• Nanoemulsion Vitamin D may be a substantially better form includes the following comparison

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