J Autoimmun. 2019 Mar 7. pii: S0896-8411(19)30033-2. doi: 10.1016/j.jaut.2019.03.002.
Yamamoto E1, Jørgensen TN2.
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Animal Model of Autoimmunity
Vitamin D deficiency is an established risk factor for many autoimmune diseases and the anti-inflammatory properties of vitamin D underscore its potential therapeutic value for these diseases. However, results of vitamin D3 supplementation clinical trials have been varied. To understand the clinical heterogeneity, we reviewed the pre-clinical data on vitamin D activity in four common autoimmune diseases:
- multiple sclerosis (MS),
- rheumatoid arthritis (RA),
- systemic lupus erythematosus (SLE), and
- inflammatory bowel disease (IBD),
in which patients are commonly maintained on oral vitamin D3 supplementation. In contrast, many pre-clinical studies utilize other methods of manipulation (i.e. genetic, injection). Given the many actions of vitamin D3 and data supporting a vitamin D-independent role of the Vitamin D receptor (VDR), a more detailed mechanistic understanding of vitamin D3 activity is needed to properly translate pre-clinical findings into the clinic. Therefore, we assessed studies based on route of vitamin D3 administration, and identified where discrepancies in results exist and where more research is needed to establish the benefit of vitamin D supplementation.
See also Vitamin D Life
Items in both categories Lupus and Vitamin D Receptor are listed here:
- Active Lupus associated with 3.8 X less activated Vitamin D Receptor – May 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017
- Lupus associated with both low vitamin D and Vitamin D receptor problems – April 2016
Items in both categories Autoimmune and Vitamin D Receptor are listed here:
- Autoimmune disease treated by Vitamin D, Zinc (and other activators of Vitamin D Receptor) – Oct 2019
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Temporary hair loss (Telogen Effluvium) is 15X more likely if poor Vitamin D Receptor – Oct 2019
- Autoimmunity problems often associated with poor Vitamin D Receptors – March 2019
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Resveratrol improves health (Vitamin D receptor, etc.)
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Vitamin D Receptor and autoimmune diseases – Jan 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Familial Mediterranean Fever is 3X more likely if poor Vitamin D Receptors (males) – Sept 2017
- Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
- Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013
- Endometriosis treated, and perhaps prevented, by vitamin D