Speculation – Weekly vitamin D dose will be better than daily if poor Receptor

By Vitamin D Life

Unaware of any trials which support this speculation as of Sept 2017

Fact	Vitamin D Receptors restrict how much activated blood vitamin D actually gets to cells
Observation	Omega-3 given to rats weekly resulted in more Omega-3 in blood than when given daily
Observation	Increasing a daily dose of vitamin D increases the cellular vitamin D even if poor vitamin D receptor. Receptor limits, but does not entirely block
Speculation	Giving weekly dose should further increase the cellular vitamin D (nonlinear)

Graphical summary of speculation: blood level activated vitamin D ==> cell level

---

Vitamin D Receptor category in VitaminDwiki has the following

384 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement   Sun, Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D in the cells
13) Sulfroaphone and perhaps sulfur	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

If poor Vitamin D Receptor

Risk increase	Health Problem
50	Lyme Disease
28	Leprosy - another says 3X
15	Chronic Heart Failure
15	Temporary hair loss
14	Hand, Foot, and Mouth disease
13	Sepsis
11	Metabolic Syndrome
9.6	Chronic Periodontitis    and smoke
8	Juvenile Rheumatoid Arthritis
7.6	Crohn's disease
7.5	Respiratory Tract Infections
5.8	Low back pain in athletes
5	Respiratory Distress in preemies
5	Ulcerative Colitis
5	Coronary Artery Disease
5	Asthma Child see also 1.3, 2.0 and 3.6
4.6	Breast Cancer 16.9 X another study
4.1	Vitiligo
4	Polycystic ovary syndrome
3.6	Pneumonia - children
3.3	Pre-term birth
3.1	Colon Cancer survival
3	Multiple Sclerosis
3	Dengue
3	Waist size
3	Ischemic Stroke
3	Alzheimer’s
3	Gestational Diabetes
2.9	Hand, Foot, Mouth Disease
2.8	Osteoporosis & COPD
2.7	Gastric Cancer
2.6	Lupus in children
2.5	Lumbar Disc Degeneration
2.4	Lung Cancer
2.3	Autism
2.2	Juvenile idiopathic arthritis
2.1	Adolescent idiopathic scoliosis in Asians
2	Diabetic Retinopathy
2	Parkinson's
2	Wheezing/Asthma see also 5X
2	Melanoma   Non-melanoma Skin Cancers
2	Myopia
2	Preeclampsia
1.9	Uterine Fibroids
1.9	Early tooth decay
1.8	Diabetic nephropathy
1.8	Sleep Apnea
1.6	Diabetes - Type I
1.6	Prostate Cancer while black
1.5	Diabetes -Type II
1.5	Pertusus
1.5	Obesity
1.4	Graves Disease
1.4	Rheumatoid arthritis
1.3	Childhood asthma see also 5X
1.3	Psoriasis in Caucasians
1.3	Tuberculosis
??	Rickets - Vitamin D resistant