Table of contents
The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis
Iran JPublic Health, Vol. 51, No.2, Feb 2022, pp.278-291
Maryam Emadzadeh1, Atieh Mehdizadeh 2, Pay am Sharifan 3, Mahdieh Khoshakhlagh Reza Sahebi 5,6, Ramin Sadeghi 7, Gordon A. Ferns 8, *Majid Ghayour-Mobarhan 9
Corresponding Author: Email: ghayourm at mums.ac.ir
Background: Vitamin D plays an essential role in the regulation of bone metabolism. The current meta-analysis aimed to assess the effectiveness of vitamin D fortification on special bone biomarkers.
Methods: Five main databases (PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus, Cochrane Library as well as Science Direct, and Scopus) were considered for this systematic review, until Jan 2020. All randomized controlled trials were included to evaluate the probable relationship between consumption of vitamin D fortification products and bone biomarkers profile in this review.
Results: Among serum bone biomarkers (osteocalcin and telopeptides of type-1 collagen) investigated, only the level of telopeptides of type-1 collagen significantly decreased after fortification of vitamin D in the intervention group. A significant increase in vitamin D was seen in those older than 18 yr old, while the increase in younger children was not statistically significant between intervention and control groups.
Conclusion: Vitamin D fortification was not associated with a significant improvement in bone mass density (BMD), while it resulted in decreased PTH levels. Vitamin D fortified foods have some benefits on bone health due to increase in the level of vitamin D and IGF-1; and decreasing PTH and CTx levels.
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Vitamin D Life - Fortification with Vitamin D contains
Fortification works, even if food is cooked, but govts rarely fortifiy with enough
Govts, food producers, and families can fortify:
milk, yogurt, beer, bread, cereals, cooking oil, soups, jams, jellys, honey, snack bars, etc.
Some interesting fortification articles
- After years of adding vitamin D, Finland now has 35 ng levels - March 2022
- Fortification with Vitamin D works – 16 studies of Danish experience – July 2021
- Vitamin D fortification of beverages – Review March 2022
- Vitamin D-fortified bread: Systematic review – March 2022
- International Conference of Vitamin D Fortification of Food (India) – Sept 2018
- 2400 IU of vitamin D needed to get most Northern adults above 20 ng – June 2020
- Most Fortification studies do not give enough to make a difference
- Vitamin D home fortification- don't wait 100 years for your govt
Vitamin D Life - Bread Fortification studies often use a lot of vitamin D
Vitamin D Life Fortification pages with BREAD in title
This list is automatically updated
Vitamin D needed to TREAT Health problems (30 ng for Rickets)
| Vitamin D | Treats |
| 150 ng | Multiple Sclerosis * |
| 80 ng | Cluster Headache * Reduced office visits by 4X * |
| 70 ng | Sleep * |
| 60 ng | Preeclampsia RCT |
| 50 ng | COVID-19 Fertility Psoriasis Infections Review Infection after surgery |
| 40 ng | Depression ACL recovery Hypertension Asthma? |
| 30 ng | Rickets |
* Evolution of experiments with patients, often also need co-factors
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