Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023

Recent progress in nanotechnology-based drug carriers for resveratrol delivery

Drug Delivery Volume 30, 2023 - Issue 1 https://doi.org/10.1080/10717544.2023.2174206
Chunhong Li,Zhen Wang,Hui Lei &Dan Zhang

AuC: area under the concentration-time curve (plasma exposure);
t1/2: plasma half life;    Cl: clearance;
MrT: mean residence time;    Cmax: peak plasma concentration;
AuC0 →∞: area under the concentration time-curve from time zero to infinity;

Forms

Resveratrol is a polyphenol with diverse pharmacological activities, but its clinical efficacy is limited due to low solubility/permeability, light-induced isomerization, auto-oxidation, and rapid metabolism. Nanodelivery systems, such as liposomes, polymeric nanoparticles, lipid nanocarriers, micelles, nanocrystals, inorganic nanoparticles, nanoemulsions, protein-based nanoparticles, exosomes, macrophages, and red blood cells (RBCs) have shown great potential for improving the solubility, biocompatibility, and therapeutic efficacy of resveratrol. This review comprehensively summarizes the recent advances in resveratrol nanoencapsulation and describes potential strategies to improve the pharmacokinetics of existing nanoformulations, enhance targeting, reduce toxicity, and increase drug release and encapsulation efficiency. The article also suggests that in order to avoid potential safety issues, resveratrol nanoformulations must be tested in vivo in a wide range of diseases.
 Download the PDF from Vitamin D Life
Note: Neither Vitamin D nor Vitamin D receptor occur in the PDF

Vitamin D Life - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of Vitamin D Life uses 10 of the 16 known VDR activators

Vitamin D Life – Resveratrol improves health (Vitamin D receptor, etc.) contains

• The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
• Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
• Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
• Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
  • Quercetin and Curcumin in the case of Resveratro

Vitamin D Life – Vitamin D Receptor category contains

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Many Amazon suppliers sell liposomal Resveratrol

Amazon
Some of the items listed are liposomal tumeric/curcumin combined with Reseratrol (probably OK)
Ignore the non-liposomal products (wonder how trans compares to liposomal)
Founder of Vitamin D Life bought NATURE'S ESSENTIALS July 2023
Note: A DNA test disclosed that both he and his wife have poor Vitamin D Receptors

Resveratrol increases the cellular Vitamin D by activating the VDR

click here for details

Chat-GPT comparision of Trans and Liposomal forms - July 2023

• Liposomal resveratrol is a formulation that encapsulates resveratrol in liposomes - small spherical vesicles made from phospholipids. This formulation is aimed at improving the bioavailability of resveratrol, meaning that it may be better absorbed and stay in the bloodstream for a longer period of time compared to non-encapsulated resveratrol.
• Here is a comparison between liposomal resveratrol and trans-resveratrol:
• Bioavailability: Liposomal resveratrol is thought to have higher bioavailability compared to regular trans-resveratrol. The liposomal encapsulation is intended to protect resveratrol from degradation in the digestive system and facilitate its absorption into the bloodstream.
• Effectiveness: Due to the increased bioavailability, liposomal resveratrol may be more effective at delivering the potential health benefits of resveratrol.
• Cost: Liposomal formulations are generally more expensive to produce, so liposomal resveratrol supplements may be more expensive compared to regular trans-resveratrol supplements.
• Research and Evidence: As of 2021, there is a considerable amount of research on trans-resveratrol, but limited research on liposomal resveratrol. It’s important to note that while the liposomal form might offer better bioavailability, further studies are needed to confirm its long-term efficacy and safety.
• Administration and Dosage: Liposomal resveratrol is usually available in liquid form, which might be easier for some people to take compared to capsules or tablets of trans-resveratrol.